.
44th ASMS Conference on Mass Spectrometry and Allied Topics May 12 - 16,1996, Portland Convention Center, Portland, Oregon Preliminary Program For information on registration, contact: ASMS 1201 Don Diego Avenue Santa Fe, NM 87505 Telephone: (505) 989-4517 Fax: (505) 989-1073 e-mail:
[email protected] Abstracts for all papers listed here will be available on the ASMS Web page after March 15,1996, at the following address: http://www.asms.org Please note this change in the ASMS Webpage address.
SUNDAY PROGRAM, May 12,1996. Sunday sessions will be held in the Ballroom of the Oregon Convention Center. 1-7 pm Registration 4-4:30 pm ASMS Meeting and Welcome TUTORIAL SESSIONS. Open to all conference registrants. 4:30-6 pm Session I Making Ions from Molecules: Desorption Ionization, Kenneth L. Busch, Georgia Institute of Technology Product Ion Formation: Collision Induced Dissociation, Stephen A. Martin, PerSeptive Biosystems 4:30-6 pm Session II Ion Thermochemistry in Ten Easy Lessons, Robert R. Squires, Purdue University Fragmentation: A Conceptual Introduction to the Statistical Theory, Scott A. McLuckey, Oak Ridge National Laboratory 6-7:30 pm Welcome Mixer PROGRAM
NOTES Conference Workshops are scheduled 12:30-2 pm, Monday through Thursday of conference week. Refer to the ASMS News in this issue for a complete listing of workshops.
Title information provided here was assembled from electronic abstract submission directly from the authors. This information has not been edited. MONDAY
ORAL SESSIONS
Monday 8:30 PLENARY LECTURE The Chilling Story of an Atomic Identity Crisis: Bose-Einstein Condensation in a Gas, Carl E. Wieman, JILA and Department of Physics, University of Colorado Monday ELECTROSPRAY AND MALDI OF LARGE MOLECULES, Kevin Schey, presiding A.; MOA 09:30 Studying Noncovalent Protein-RNA Interactions by Electrospray Ionization Mass Spectrometry; *Loo, Joseph Sannes, KristinA.; Parke-Davis Pharmaceutical Research, Ann Arbor, MI Proteins;Lei, Paula; MOA 09:50 ES1 Studies of Metal Binding and Noncovalent Associations in Nonheme Iron-Containing *Amster,Jonathan; Chemushevich, Igor; Standing,Ken; Department of Chemistry,Universityof Georgia,Athens,GA 30602 MOA 1O:lO Probing macromolecular complexes by electrospray; *Robinson, Carol;Chung,Evonne; Grob,Michael;Radford, Sheena;Dobson,Christopher; OxfordCentrefor MolecularScience MOA lo:30 MALDI MassSpectrometryasa Readoutof BiomolecularInteractions;*Fitzgerald,Michael,C.; Dawson,Philip; Muir, Tom;Kent, Stephen,B. H.; TheScrippsResearch Institute,La Jolla,CA 1050 Break MOA 11 :I0 Mass Spectrometric Contributions to Protein X-ray Crystallography; *Cohen,StevenL.; Chait,BrianT.; The RockefellerUniversity,NewYork City, NY of Immunoglobulins Using MALDI-MS; *Dogruel,David;Nelson,RandallW.; Williams,Peter; MOA 11:30 Characterization Merkle,DeniseL.; Schenetman, Mark A.; Johnson, Syd;Pfarr,David;Arizona StateUniversity MOA 11:50 Elucidating the Complete Primary Structure of Glycoprotein Glycans with Mass Spectrometry; *Orlando, Ron; Yang,Yi; Austin,Troy; Levin,Todd;CCRC,Unniversityof Georgia,Athens,GA 30602 12:10 LunchBreak,Workshops, Posters 0 1996AmericanSocietyfor MassSpectrometry 1044-0305/96/%15.00 PII SlO440305(96)00079-7
PRELIMINARY
MOA MOA MOA MOA
375
PROGRAM
4:30
Charge Detection Mass Spectrometry of Macromolecules above 1 Million AMU; *Fuerstenau, Stephen; Benner, W. Henry; .Lawrence Berkeley National Laboratory 4:50 DNA Sequence Information by Tandem Mass Spectrometry; l Aaserud, David, J.; Little, Daniel, P.; Valaskovic, Gary, A.; Guan, Ziqiang; Kelleher, Neil, L.; McLafferty, Fred, W.; Cornell University, Ithaca, NY 5:lO Aspects of Mass Spectrometric Analysis of Electroblots from 2D-PAGE separations by IR-MALDI; *Strupat, Kerstin; Eckerskom, Christoph; Schleuder, Detlev; Hochstrasser, Denis; Lottspeich, Friedrich; Hillenkamp, Franz; Institute for Medical Physics and Biophysics, University of Muenster 5:30 Molecular Anatomy of Brain using Multi-Dimensional HPLC-ESUMS Systems; *Seta, Kazuo; Isobe, Toshiaki; Nakayama, Hiroshi; Shinkai, Fumiko; Kanai, Michiko; Yamaguchi, Mihoko; Okuyama, Tsuneo; Biochemistry, Tokyo Metrooolitan Universitv
Monday
NEW DEVELOPMENTS
AND APPLICATIONS
IN INORGANIC MASS SPECTROMETRY,
Christopher Barshick, presiding MOB
09:30
MOB
09:50
MOB
IO:10
MOB
IO:30
IO:50 MOB
11:lO
MOB
I I:30
MOB
II:50 12:lO
MOB
4:30
MOB
4:50
MOB
5:10
MOB
5:30
Monday MOC 09:30 MOC
09:50
MOC
IO:10
MOC
IO:30
MOC
lo:50 I 1:lO
MOC
1 I :30
MOC
11:50
MOC
12: IO 4:30
MOC
4:50
MOC
5:10
Atomic MS Of Solids By Use Of A Microsecond Pulse Discharge And A Time Of Flight Mass Analyzer; *Harrison, Willard; University of Florida, Gainesville, Florida Recent Developments in Elemental Mass Analysis Using FTICR Mass Spectrometry; *Eyler, John; Goodner, Kevin; Milgram, Eric; Watson, Clifford; Dejsupa, Chadin; Barshick, Chris; Department of Chemistry, University of Florida, Gainesville, Florida Electrospray Mass Spectrometry of Inorganic Ions Using Oscillating Capillary Nebulizer; *Shou, Zhenyu; Ho, Zhanying Stacy; Browner, Richard F.; School of Chem. & Biochem., Georgia Tech, Atlanta, GA 30332-0400 A Second-Generation Inductively Coupled Plasma-Time-of-Flight Mass Spectrometer (ICP-TOFMS); *Hieftje, Gary M.; Li, Gangqiang; Myers, David P.; Ray, Steven J.; Mahoney, Patrick P.; Department of Chemistry, Indiana University, Bloomington, IN 47405 Break Elemental Analysis Using Pulsed Radio Frequency Glow Discharge Time-of-Flight Mass Spectrometry; *Steiner, Robert E.; King, Fred L.; West Virginia University Improving Signal-To-Noise In Glow Discharge Ion Trap Mass Spectrometry; *Duckworth, Douglas C.; McLuckey, Scott A.; Chemical and Analytical Sciences Division, Oak Ridge.National Laboratory Glow Discharge Ion Source Design Considerations for Particle Beam LCIMS; *DePalma, Jr., Patrick; You, Jianzhang; Marcus, R. Kenneth; Clemson University Lunch Break, Workshops, Posters Elemental and Molecular Dual Mode Analysis by Ionspray Mass Spectrometry; *Corr, Jay; SCIEX, Concord, Ontario, Canada Glow Discharge Mass Spectrometry and Gas Chromatography/Mass Spectrometry: Complementary Techniques?; *Barshick, Stacy-Ann; Barshick, Christopher, M.; Mohill, Matthew, L.; Britt, Phillip, F.; Oak Ridge National Laboratory Quantitation of selenium in plants,soils and sewage sludges by isotope dilution CC/MS.; l MacLeod, Fiona; McGaw, Brian; Shand, Charles; Robert Gordon University, Aberdeen, Scotland Speciation of Arsenic in Reference Materials by using micro-HPLC / ICPMS; *Pergantis, Spiros, A.; Heithmar, Edward, M.; Hinners, Thomas, A.; Momplaisir, George+Marie; U.S. Environmental Protection Agency, Las Vegas, NV
EMERGING METHODS FOR BIOMEDICAL
APPLICATIONS,
Sanford l? Markey, presiding
Surface Modification and Secondary Ion Imaging of Biologic Tissue by SIMS: *Todd, Peter J.; McCandlish, Carl A.; McMahon, John M.; Oak Ridge National Laboratory, Oak Ridge, TN Subcellular imaging of ionic and molecular transport with dynamic SIMS ion microscopy; l Chandra, Subhash; Cornell University, Ithaca, N.Y. 14853 High-Spatial-Resolution Secondary Ion Mass Spectrometry for Biomedical Applications; *Chabala, Jan; Levi-Setti, Riccardo; University of Chicago, Chicago, IL Mechanisms of Molecular Desorption Induced by keV Ion Bombardment of Organic and Biological Surfaces; *Riederer, Donald E.; Chatterjee, Reema; Rosencrance, Scott W.; *Postawa, Zbigniew; Dunbar, Timothy D.; Allara, David L.; Winograd, Nicholas; The Pennsylvania State University Break Secondary Ion Imaging of Stable Isotopes in Biological Tissues: Progress and Prospects; *Linton, Richard W.; Lazof, Dennis B.; Goldsmith, Jack G.; Gillen, Gregory; Rutty, Thomas W.; Department of Chemistry, University of North Carolina, Chapel Hill, NC Replacing 14C with stable isotopes in drug metabolism studies; *Abramson, Fred; Teffera, Yohannes; Kusmierz, Josef; Steenwyk, Rick; Pearson, Paul; George Washington University, Washington DC Organic Ion Imaging by High Performance Time-of-Flight Secondary Ion Mass Spectrometry; *Odom, Robert; Charles Evans & Associates Redwood City, CA 94063 Lunch Break, Workshops, Posters Coupling Time-of-Flight MALDI with Thin-Layer Chromatography; *Hercules, David M.; Vanderbilt University, Nashville, TN 37235 From 1-D and 2-D polyacrylamide gels to MALDI-MS; *Ogorzalek Loo, Rachel; Mitchell, Charles; Stevenson, Tracy; Loo, Joseph; Andrews, Philip; Dept. of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109 Use of Bioreactive Probe Tips in the MALDI Mass Spectrometric Characterization of Proteins.; *Nelson, Randall; Dogruel, David; Krone, Jennifer; Lewis, Kathleen; Williams, Peter; Arizona State University
376 .
44TH
ASMS
CONFERENCE
ON
MASS
SPECTROMETRY
. MOC
530
ICR Spectra of Olegonucleotide-Primer Generated with the EPID Method; Spiess, Iris; *Wanczek, Karl P.; Inst. of Inorg. and Phys. Chemistry, University of Bremen, D-28334 Bremen
Monday
HISTORY OF VARIOUS MASS SEPARATION TECHNIQUES, Michael Grayson, presiding
MOD
Preparative Scale Mass Spectrometry: A Brief History of the Calutron; *Yergey, Alfred; Philips, Lawrence; National Institute of Child Health and Human Development, NIH Magnetic and Electric Sector Mass Analyzers; *Futrell, Jean;; University of Delaware, Newark, DE Break Time-of-Flight = Fifty Years: the Search for a Larger Mass Range and Better Resolution; *Standing, Kenneth G. ; Physics Dept., University of Manitoba, Winnipeg, Canada R3T2N2 Lunch Break, Workshops, Posters A Historical Review of the Science and Technology of Quadrupole Mass Spectrometry; *Story, Michael; Therm0 Instrument Systems Inc Efticiency Improvements in Mass Separation Techniques, * *McLafferty, Fred W.; Cornell University, Ithaca, NY
MOD
09:30 10: 10
IO:50 MOD
I I :lO
MOD
12: 10 4:30
MOD
5:lO
Monday
REACTIONS OF GAS PHASE IONS, Hilkku Kentt~mau,presiding
MOE
09:30
MOE
1O:lO
MOE
IO:30
MOE
IO:50 II:10
MOE
I I:30
MOE
11:50
Holy Grails in Gas-Phase Ion Chemistry: A Personal View; *Schwarz, Helmut; Department of Chemistry, Technical University of Berlin, Berlin Protonation Sites in Nitrogen Heterocycles by Neutralization-Reionization Mass Spectrometry; Nguyen, Viet; *Turecek, Frantisek; Wolken, Jill; University of Washington, Seattle Mechanisms for Propene Expulsion from Ionized Propyl Phenyl Ethers, C3H70Ph+.; *Morton, Thomas Hellman; Traeger, John C.; University of California, Riverside Break Gas Phase Reactions Between Charged Lewis Acids and Glycine and Other Small Biomolecules.; *O’Hair, Richard; Freitas, Michael; Schmidt, Joseph; Williams, Todd; Department of Chemistry, Kansas State University, Manhattan, KS 66506-3701 The Role of Charge State on the Conformation and Dissociation Energetics of Biomolecule Ions; *Williams, Evan; Price, William; Schnier, Paul; Gross, Deborah; University of California, Berkeley Influence of N- and C-Terminal Arginines on Peptide Decay: Evidence of Intramolecular H-Bonding; *Russell, David H.; Gimon-Kinsel, Mary E.; Texas A&M University, College Station Lunch Break, Workshops, Posters Ion-ion and Ion-molecule Reactions of Multiply Charged Ions in the Paul Trap; *McLuckey, Scott A.; Stephenson, Jr., James L.; Herron, William J.; Goeringer, Douglas E.; Oak Ridge National Laboratory, Oak Ridge, TN Potential energy surfaces of the reactions of doubly charged ions: a computational approach.; *Gronert, Scott; San Francisco State University, San Francisco, CA Hydration Enthalpies of Electrospray-Generated Doubly Charged Gas Phase Ions; Blades, Arthur, T.; Klassen, John, S.; *Kebarle, Paul; Department of Chemistry, University of Alberta, Edmonton, Canada SIFT/CID Studies of “Fuzzy-Ball” and “Ball-and-Chain” Derivatization of C60 Cations.; Baranov, Vladimir; Hopkinson, Alan, C.; l Bohme, Diethard, K.; York University, North York, Ontario, Canada
l2:lO MOE
4:30
MOE
4:50
MOE
5:lO
MOE
5:30
Monday
MOVING MASS SPEC OUT OF THE LAB: IN-SITU, ON-LINE AND PORTABLE MS APPLICATIONS, Steven Doherty, presiding
MOF
09:30
MOF
IO:10
MOF
lo:30
MOF
IO:50 I I :lO
MOF
11:30
MOF
I I:50
MOF
12: 10 4:30
MOF
4:50
MOF
5:lO
MOF
5:30
On-line monitoring reaction monitoring using membrane introduction mass spectrometry; *Cooks, R. G.; Johnson, R. C. ; Srinivasan, N.; Kasthurikrishna, N.; Wong , P.S. H.; Purdue University, West Lafayette Copolymer Membranes for the MIMS Analysis of Volatile Organic Compounds; *Ohorodnik, Susan; Anderson, Mark; Callahan, John; Naval Research Laboratory Development of an on-site system for the detection of gases and organic compounds in water; Matz, Gerhard; *Kibelka, Gottfried; Technical University Hamburg-Harburg Break Evaluation of ion sources for online analysis of gasphase organics in dynamic sample streams; *Dearth, Mark; Ford Motor Company, Maildrop SRL 3 I79 Development of a Hand-PortablePhoto-Ionization Time-of-Flight Mass Spectrometer; *Dieckman, Stephen; Bostrom, Gregory; Waterfield, L. Glen; Jendrzejczyk, Joseph; Raptis, A. C. (Paul); Argonne National Laboratory, Argonne Illinois Rounded hyperbolic quadrupoles RHQ (tm) implemented in a novel MS-MS type instrument; *Steiner, Urs; Jones, Larry; Sokolow, Steve; Bear Instruments, Inc Lunch Break, Workshops, Posters MS and MS/MS Performance of a Field-Portable Ion Trap Mass Spectrometer for CWC Treaty Compounds; *Lammert, Stephen A.; Palausky, M. Andi; Oak Ridge National Laboratory In-situ Measurement of Size and Composition of Airborne Particulate Matter using a Portable ATOFMS; *Gard, Eric; Dienes, Tas; Fergenson, David; Morrical, Brad; Prather, Kimberly A.; Department of Chemitry, University of California Riverside 92521 On-Line Chemical Process and Emissions Monitoring with a Transportable MBMS Instrument; *Ratcliff, Matthew; Gratson, David; Gebhard, Steven; French, Richard; Patrick, Joseph; Meglen, Robert; National Renewable Energy Laboratory (NREL), Golden, CO A Field CC/Ion Trap MassSpectrometer - From Concept to Customer; *Cisper, Mary; Hemberger, Philip; Los Alamos National Laboratory, Los Alamos, NM
PRELIMINARY
377
PROGRAM
TUESDAY
ORAL SESSIONS
Tuesday 8:30 PLENARY LECTURE Ion Gamesin a Magnetic Gymnasium: Attomoles to MegaDaltons, Afun G. Marshall, National High Magnetic Field Laboratory, Florida State University Tuesday ELECTROSPRAY AND MALDI OF SMALL MOLECULES, Dominic Desiderfo,presiding TOA 09:30 MALDI-ITMS asa Tool for BiomoleculeStructure Analysis:*Chait, Brian T.: Oin. Jun: The Rockefeller Universitv. TOA TOA TOA TOA TOA
TOA TOA TOA
TOA
1230 York Ave., New York, NY 10021 IO:10 RealTime Protein Identification to Guide Tandem MS Investigations of Unseparated Peptide Mixtures; +Wilm, Matthias; Shevchenko, Andrej; Mann, Matthias; European Molecular Biology Laboratory IO:30 Investigations of Protein Structure using Bioreactive Probe Tips and Quantitative MALDI; *Lewis, Kathleen; Krone, Jennifer; Dogruel, David; Williams, Peter; Nelson, Randall; Arizona State University 1050 Break II:10 Characterization of Synthetic Peptides using MALDI and Electrospray Mass Spectrometry; *Carroll, James; Brostowin, Janet; Beavis, Ronald; The Skirball Institute, New York University Medical Center, New York, NY II:30 The Development of ESI-TOF and It’s Comparison with MALDI-TOF for the Characterization of Peptides.; *Vestal, Marvin; Verentchikov, Anatoli; Hsieh, Frank; Gabeler, Steve; Zhou, Joe; Takach, Edward; Martin, Stephen; PerSeptive Biosystems, Inc., Framingham, MA I I:50 MALDI mass spectrometry of peptidoglycan oligomers after size exclusion chromatography and HPLC; *Allmaier, Gilnter; Zenker, Andrea; Pfanzagl, Beatrix; Loffelhardt, Wolfgang; Institute for Analytical Chemistry, University of Vienna, Vienna, Austria l2:lO Lunch Break, Workshops, Posters 4:30 TMPP-Derivatives: A New Generation of Charged Derivatives for Desorption Ionization MS; *Watson, J.T.; Huang, Z.-H.; Liao, P.-C.; Wu, J.; Roth, K.D.W.; Lavine, G.; Gage, D.A.; Allison, J.; Dept. of Biochemistry, Michigan State University, East Lansing, MI 48824 4:50 Chracterization of Bovine Adrenal Modullary Peptides by using ESI-MS and LCIESI-MS; *Dass, Chhabil; Department of Chemistry, The University of Memphis, Memphis, TN 38152 5:lO Coordination sites of Alkali Metals Complexed to Oligosaccharides Dictate Fragmentation Behavior; *CancilIa, Mark T.; Penn, Sharron Cl.; Carroll , James A.; Lebrilla, Carlito B.;; Department of Chemistry, University of California, Davis 5:30 MALDI I PSD Peptide Fragment-Ion Tagging and Mass Fingerprinting of Placental Proteins from 2D PAGE; *Clauser, Karl R.; Foulk, Russell A.; Baker, Peter; Fisher, Susan J.; Burlingame, Alma L.; Department of Pharmaceutical Chemistry, Univ. of California, San Francisco
Tuesday
FRONTIERS IN ISOTOPE RATIO MEASUREMENTS, DouglasDuckworth, presiding
TOB
09:30
TOB
IO:10
TOB
IO:30
TOB
IO:50 I I :I0
TOB
I I :30
TOB
I I :50
TOB
12: IO 4:30
TOB
5: IO
TOB
5:30
Mechanisms in Thermal Ionization; *Delmore, Jim; Appelhans, Tony; Huett, Tom; Olson, John; Idaho National Engineering Laboratory Ionization Mechanism and Theory of Thermal Ionization Sources, On the Road to Higher Efficiency; *Olivares, Jose; Duan, Yixiang; Los Alamos National Laboratory, Los Alamos, NM Environmental and nuclear applications of isotope ratio mass spectrometry; l Wacker, J.F.; Farmer, O.T.; Gerlach, DC.; Kelley, J.M.; Koppenaal, D.W.; Smith, M.R.; Pacific Northwest National Laboratory Break Isotope Ratio Measurements Using a Multi-collector Inductively Coupled Plasma Mass Spectrometer; *Smith, David H.; Duckworth, Douglas C.; Barshick, Christopher M.; Riciputi, Lee R.; McBay, E.H.; McPherson, R.L.; Turner, M.L.; Valiga, R.E.; Chemical and Analytical Sciences Division, Oak Ridge National Laboratory RF-Glow Discharge Ion Trap Mass Spectrometry- A Look at Elemental Analysis and Isotope Ratios; *Eanes, Ritchie; Marcus, R. Kenneth; Clemson University; Clemson, SC Performance Test of a Moving Wire Interface for Isotope-Ratio-Monitoring LCMS; Brand, Willi A.; ‘Dobberstein, Peter; Pesch, Reinhold; Schroeder, Ernst; Finnigan MAT GmbH, D-28197 Bremen, Germany Lunch Break, Workshops, Posters A novel approach for studying calcium fluxes at subcellular scale: SIMS imaging of stable isotopes; *Chandra, Subhash; Cornell University, Ithaca, N.Y. 14853 High-Precision D/H Measurement From Organic Mixtures By Continuous-Flow IRMS Using A Pd Filter; *Tobias, Herbert; Brenna, J. Thomas; Division of Nutritional Sciences, Cornell University, Ithaca NY Hair Analysis for Detection of Drugs of Abuse; *Cairns, Thomas; Cheng, Chen-Chih; Scholtz, Henry; Wang, WenLing; Psychemedics Corporation, 5832 Uplander Way, Culver City, California 90230
Tuesday TOC TOC
TOC
09:30 IO:10
MASS SPECTROMETRY
The role of mass spectrometry LC/MS/MS of Buprenorphine Alan; Crouch, Dennis; Wilkins, Utah, Salt Lake City, UT IO:30 Tandem mass spectrometry in IO:50 Break
IN PHARMACOLOGY
AND TOXICOLOGY,
ThomasBoillie, presiding
*Blair, Ian A.;; Vanderbilt University in drug metabolism and pharmacokinetics; and Norbuprenorphine in Human Plasma and Hair; *Laycock, John; Spanbauer, Diana; Moody, David; Foltz, Rodger; Center for Human Toxicology, University of natural products discovery; *Julian, Jr., Randall K.; Eli Lilly and Company.
378
TOC
44TH
ASMS
CONFERENCE
ON
MASS
SPECTROMETRY
11 :lO New Automated Data Acquisition and Processing Tools for Pharmaceutical Research Utilizing API/MS/MS; *Shushan, Bori; Covey, Tom; Allen, Mark; Anacleto, Joe; Bonner, Ron; PE SCIEX, Concord, Ontario TOC I I:30 Rapid In vivo Pharmacokinetic Screening of Drug Discovery Mixtures Using APCI LCIMS; *Halm, Kathy; Adkison, Kim; Berman, Judd; Shaffer, Joel; Glaxo Wellcome, Inc. TOC I I:50 Rapid Screening Procedures for Metabolic Stability and Biotransformation of; *King, Richard; Femandez, Carmen; Baillie, Thomas; Owens, Kevin; Merck Research Laboratories, West Point, PA 12: IO Lunch Break, Workshops, Posters TOC 4:30 EWMS Studies of Metabolic Enzymes: Elucidation of Mechanism and Design of Enzyme Inactivators; *Jones, A. Daniel; Borhan, Babak; Zheng, Jiang; Mitchell, Alyson E.; Pinot, Franck; Grant, David F.; Kurth, Mark J.; Hammock, Bruce D.; University of California-Davis, Davis, CA *Antoine, Miquel; Fabris, Daniele; Han, Mark; TOC 450 Covalent Sequestration of Meohlorethamine by Metallothionein; Fenselau, Catherine; UMBC, Baltilmore, MD TOC 5: IO Covalent Binding of Reactive Eicosanoid Intermediates with Target Proteins; * Waugh, Russell; Clay, Keith; Murphy, Robert; National Jewish Center for Immunology and Respiratory Medicine, Denver, CO. TOC 5:30 The analysis of the urinary mercapturate of vinyl chloride using ID-HPLC-MS/MS; *Shealy, Dana B.; Ashley, David L.; Centers for Disease Control and Prevention TOF METHODS FOR DNA SEQUENCING, Robert Coffer, presiding Tuesday TOD 09:30 MALDI-TOF-MS-a New Paradigm for DNA Detection: Applications in DNA Diagnostics and DNA Sequencing; *Koster, Hubert ; University of Hamburg TOD 09:50 Various TOF Mass Spectrometric Approaches for DNA Sequencing, * *Chen, Winston; Zhu, Yi-Fei; Taranenko, Nelli; Allman, Steve; Oak Ridge National Laboratory TOD IO:10 DNA Analysis for Rapid Genetic Screening with MALDI TOF Mass Spectrometry; *Liu, Yan-Hui; Bai , Jian; Zhu, Yongdong; Liang, Xiaoli; Lubman, David M.; Department of Chemistry, The University of Michigan, Ann Arbor, MI 48109 TOD IO:30 Characterization of Oligonucleotide Strands by Enzymatic Digestion and MALDI-TOF; *Bentzley, Catherine; Johnston, Murray; Larsen, Barbara; Gutteridge, Steven; University of Delaware, Newark, DE IO:50 Break TOD I I: IO Fragmentation in the MALDI-TOF Analysis of Nucleic Acids; *Smith, Lloyd M.; Nelson, Christine; Tang, Wei; Zhu, Lin; Department of Chemistry, University of Wisconsin-Madison TOD I I:30 DNA-Cycle-Sanger-Sequencing by MALDI-TOF-MS with nucleotides modified for enhanced ion stability; *Nordhoff, E&hard; Kirpekar, Finn; Hahner, Stephanie; Kristiansen, Karsten; Roepstorff, Peter; Hillenkamp, Franz; Department of Molecular Biology, Odense TOD I I:50 Fragmentation of DNA in MALDI; *Chou, Chau-Wen; Williams, Peter; Arizona State University 12: IO Lunch Break, Workshops, Posters 4:30 DNA analysis using time-lag focusing MALDI TOFMS; Dai, Yuqin; Whittal, Randy; *Li, Liang; Department of TOD Chemistry, University of Alberta 4:50 Analysis and sequencing DNA by delayed extraction MALDI-TOF mass spectrometry.; *Smimov, lgor ; Roskey, TOD Mark; Juhasz, Peter; Stanick, Wendy; Takach, Edward; Martin, Stephen; Haff, Lawrence; PerSeptive BioSystems, Inc. Framingham, MA 5: IO Detailed Characterization of Antisense DNA Oligonucleotides; *Keough, T.; Shaffer, J.D.; Lacey, M.P.; Riley, T.A.; TOD Marvin, W.B.; Scurria, M.A.; Hasselfield, J.A.; Hesselberth, E.P.; The Procter and Gamble Co. TOD 5:30 MALDI-TOFMS of Double-Stranded DNAs immobilized on Solid Surfaces; *Tang, Kai; Fu, Dongjing; Kotter, Sven; Cotter, Robert; Cantor, Charles; Koster, Hubert; Sequenom Inc., Boston, MA Tuesday HOST-GUEST INTERACTIONS, Dovid Dearden,presiding TOE 09:30 Energy-resolved CID threshold studies of metal-polyether complexes; *Sunderlin, Lee; Do, Khanh; Klein, Tim; Northern Illinois University TOE 09:50 Guided Ion Beam Studies of the Binding Energies for Alkali Metal Ion Crown Ether Complexes; *Armentrout, Peter B.; More, Michelle; Ray, Doug; Feller, David; Glendening, Eric; Chemistry Department, University of Utah, Salt Lake City, UT 841 I2 TOE 10: 10 Formation and binding energies of metal-ionlcoronene complexes and sandwiches; *Dunbar, Robert C.; Pozniak, Boguslav P.; Klippenstein, Stephen J.; Case Western Reserve University, Cleveland, OH TOE IO:30 MALDI Analysis of Crown Ether Interactions with Cations; *Fang, Tong; Lynn, Jr., Bert C.; Mississippi State University IO:50 Break TOE 1 I : IO Multiple Binding Interactions in Gas-Phase Complexes; *Brodbelt, Jennifer; University of Texas, Austin, TX. TOE I I:30 Host-Guest Interactions between Cavitands or Calixarenes and Target Organic Molecules or Ions; *Vincenti, Marco; Dalcanale, Enrico; Dipartimento di Chimica Analitica, Universita di Torino, Torino, Italy TOE 1I:50 Chiral Molecular Recognition in Host-Guest Complexation detected by FABMS; *Sawada, Masami; Takai, Yoshio; Yamada, Hitoshi; Nishida, Jun; Naemura, Koichiro; The Institute of Scientific and Industrial Research, Osaka University 12: IO Lunch Break, Workshops, Posters TOE 4:30 Reaction of Mixed Alkaline Earth Clusters with Crown Ethers: Elementary Molecular Recognition?; *Pope, R. Marshall; Shen, Nanzhu; Dearden, David; Department of Chemistry and Biochemistry, Brigham Young Univ., Provo, UT
PRELIMINARY
379
PROGRAM
TOE
450
TOE
5:lO
TOE
5:30
Dependence of the Na+ and Cu+ affinities of simple biomolecules on sequence and stereochemistry; * Wesdemiotis, Chrys; Cerda, Blas A.; Deng, Wei; Chemistry Department, The University of Akron, Akron, Ohio, 44325-3601 ES1 Mass Spectrometric Studies of Cyclodextrin - Peptide Complexes and Adducts; *Prokai, Laszlo; Eyler, John; Kage, David; Nawrocki, Joseph; Watson, Clifford; Myung, Seung-Woon; Ramanathan, Ragulan; University of Florida, Gainesville Factors governing the strength of non-covalent interactions in gas-phase cyclodextrin complexes; *Penn, Sharron G.; He, Fei; Green, M. Kirk; Lebrilla, Carlito B.; Department of Chemistry, University of California, Davis
Tuesday
DIRECT SAMPLING MASS SPECTROMETRY: Dingneng Wang, presiding
TOF
09:30
TOF
IO:10
TOF
IO:30
TOF
IO:50 I I : IO
TOF
I I :30
TOF
I I:50
TOF
12: IO 4:30
TOF
4:50
TOF
5: IO
TOF
5:30
The Skimmer in Direct Sampling Mass Spectrometry; *Miller, David;; University of California at San Diego, La Jolla Sampling Methods For Supersonic Molecular Beam-Mass Spectrometry; *Amirav, Aviv; Dagan, Shai; Tel Aviv University Direct Sampling Tandem Mass Spectrometry of Premixed Flames; l Egsgaard, Helge; Larsen, Elfinn; Risi National Laboratory, DK-4000 Roskilde, Denmark Break Design and Construction of an Ion Trap Mass Spectrometer System for On-line Gas Emission Analysis; *Scoggin, Joe C.; Lynn, Jr., Bert C.; Mississippi State University Evaluation of Direct Sampling Ion Trap MS for In-Field Analysis of VOCs in Air, Water and Soil; *Wise, Marcus; Thompson, Cyril; Yelton, Richard; Oak Ridge National Laboratory Direct Analysis of Environmental Samples by Selective Sorbents and Laser Mass Spectrometry; Cisper, M.E.; Earl, W.L.; Garrett, A.W.; Gill, C.G.; *Hemberger, P.H.; Nogar, N.S.; Los Alamos National Laboratory Lunch Break, Workshops, Posters Pyrolysis-Quadrupole Ion Trap Mass Spectrometry of Pathogenic Bacteria; l Basile, France; Beverly, Michael B.; Voorhees, Kent J.; Hadfield, Ted L.; Department of Chemistry, Colorado School of Mines, Golden, Colorado On-Site Mapping of Volatile Organic Pollutant Plumes using Membrane Introduction Mass Spectrometry; *Bauer, Scott; Griffin, Timothy; Bauer, Janice; MIMS Technology Incorporated, Palm Bay, Florida Two-Step Laser Mass Spectrometry for in-situ Chemical Analysis of Complex Mixtures; *Zenobi, Renato; Zhan, Qiao; Haefliger, Olivier; ETH ZYrich Atmospheric Pressure Ionization Flow Injection Analysis Orthogonal Time of Flight Mass Spectrometry; *Andrien, Jr., Bruce; Dresch, Thomas; Haren, Patrick; Whitehouse, Craig; Analytica of Branford, Inc. 29 Business Park Drive, Branford, CT 06405
WEDNESDAY
FUNDAMENTALS
AND APPLICATIONS,
ORAL SESSIONS
Wednesday 8:30 PLENARY LECTURE Biomedical Mass Spectrometry: Blood, Sweat and Urine, Catherine C. Fenselau, Department of ChemiMy and Biochemisty, University of Maryland Baltimore County Wednesday FUNDAMENTALS OF MALDI, Werner Ens, presiding WOA
09:30
WOA
09:50
WOA
IO:10
WOA
IO:30
WOA
IO:50 I I : 10
WOA
I I :30
WOA
I I :50
WOA
12: IO 4:30
WOA
4:50
WOA
5:lO
Early Time Frame Metastable Ion Decay In MALDI; *Brown, Robert; Reiber, Duane; Feng, Jinhua; Utah State University, Logan UT 84322-0300 Novel method for the measurement of the initial velocity of ions generated by MALDI; *Juhasz, Peter; Martin, Stephen; Vestal, Marvin; PerSeptive Biosystems, Framingham, MA Ion Simulation and Experimental Investigation of the Time-Lag Focusing MALDI TOF MassSpectrometer; *Russon, Larry; Whittal, Randy; Li, Liang; Department of Chemistry, University of Alberta, Edmonton Delayed Extraction Time-of-Flight MALDI in Axial and Orthogonal Geometries; *Dworschak, Ragnar; Ens, Werner; Spicer, Vie; Standing, Kenneth G.; Department of Physics, University of Manitoba, Winnipeg, Canada R3T 2N2 Break Gas-phase cationization versus solid phase preformed ions in MALDI; *Dubois, Frederic J.; Knochenmuss, Richard; Steenvoorden, Ruud J.J.M.; Breuker, Kathrin; Zenobi, Renato; Organic Chemistry Institute, ETH Zurich, Switzerland Proton afftnities of five commonly used MALDI matrices.; *Nelson, Christine M.; Smith, Lloyd M.; Crellin, Kevin C.; Berry, Jamal; Beauchamp, Jesse L.; University of Wisconsin, Madison, WI 53705 Bioreactive Grafted Polymeric Films on Modified SteelPlatformsfor LaserDesorption of Biomolecules; Ching, Jesus; Voivodov, Kamen; Yip, Tai-Tung; *Hutchens, T. William; University of California, Davis Lunch Break, Workshops, Posters Sequencing of a Tap-Dependent Leader Peptide Using a Curved-Field-Reflectron TOF Mass Spectrometer; *Woods, A.S.; DeCloux, A.; Cordero, M.; Soloski, M.J.; Cotter, R.J.; Pharmacology, Johns Hopkins University Medical School, Baltimore, MD Ultrahigh-resolution Fourier transform mass spectrometry of biomolecules above m/z 5000; *McIver Jr., Robert T.; Li, Yunzhi; Hunter, Richard L.; Department of Chemistry, University of California, Irvine, CA 92717 Examining the MALDI Ion FormationProcess(es); *Edmondson, Ricky D.; Gillig, Kent J.; Russell, David H.; Texas A&M University, College Station
380 WOA
44TH
CONFERENCE
ON
MASS
SPECTROMETRY
for Trapping of MALDI Generated Ions Inside an ICR Cell; l Knobeler,Markus;Wanczek,Karl Peter;Instituteof Inorg.andPhys.Chemistry,University,D-28334Bremen ENERGY AND PETROCHEMICALS, Donald Drinkwater, presiding Age-Dating Hydrocarbon Contaminantion Using High Precision Lead Isotope Analyses; *Hurst,RichardW.; CHEMPETRESEARCHCORPORATION Thermal Desorption - Photoionization Mass Spectrometry of Coals and Soils; *Johnston,Murray; Bookwalter, Craig;University of Delaware, Newark,DE Characterization of Paraffin/Naphthene Hydrocarbons by LC Coupling with Field Ionization MS; *Hsu,Chang Samuel;Liang,Zhenmin;Blum,Saul;Grosshans, Peter;Robbins,Winston;Exxon Research andEngineeringCompany Break Total oletin in gasoline determined by mass spectrometry and hydrogenation.; +Cheng, Michael;Hudson,James; Drinkwater,Don;Nero,Vince; ChevronResearch andTechnologyCompanyandTexacoResearch The Analysis of Oletins by Selective Chemical Ionization MS; *Roussis, S.G.;Fedora,J.W. ; ImperialOil , Sarnia Research Centre,Sarnia,Ontario,Canada, N7T 7Ml Hydrocarbon Type analysis of cat cracked gasoline by TDNOCI CC/MS; *Dzidic, Ismet;Petersen, H.A.; Shell Development CO.,Houston,TX. LunchBreak,Workshops, Posters The Identification of Organ0 - Molybdenum Compounds in Lubricating Oil by ES1 I MS; *Nero,Vincent; Drinkwater,Donald;TexacoR&D, POBox 509,Beacon,NY 12508 Analysis of Hydrocarbon Polymers by MALDI-FTMS; *Pastor,Salvador;Wilkins,CharlesL.; Universityof California,Riverside Predicting Optimum Resolving Powers for Homolog Type Analysis of Fossil-Fuel Distillates; *Scheppele, Stuart; Research Resources Center,Universityof IllinoisChicago,Chicago,IL
5:30 New Technique
Wednesday WOB 09:30 WOB
ASMS
1O:lO
WOB lo:30 1050 WOB 1I:10 WOB 11:30 WOB 1150 12:10 WOB
4:30
WOB
4:50
WOB
5:lO
WOB
5:30
Wednesday
Low eV-HRIMS
Analysis of a Porphyrin
Fraction Separated from Cerro Negro Petroleum
by LC Methods;
*Grigsby,RonaldD.; BDM-Oklahoma/NlPER, Bartlesviile,Oklahoma MS BASED STRATEGIES FOR CHARACTERIZING BIOMOLECULE-LIGAND INTERACTIONS, JoseplrLoo, presiding
WOC 09:30 Affinity Selection- Mass Spectrometry: Identification of Lead Compounds from Combinatorial Libraries; *Huebner,VerenaD.; Kaur, Surinder;McGuire,Lisa;Tang,Dahzi;Dollinger,Gavin; ChironCorporation,Emeryville, CA WOC IO:10 Pulsed ultratiltration/electrospray MS: a new method for screening combinatorial libraries; *van Breemen, RichardB.; Huang,Chao-Ran; Nikolic, Dejan;Woodbury,CharlesP.;Zhao,Yong-Zhong;Venton,DuaneL.; Universityof Illinois atChicago,Chicago,Illinois WOC IO:30 Measurement of macromolecular binding constants using electrospray mass spectrometry; *Griffey, Richard; Greig,Michael;Cummins, Lendall;Gaus,Hans;Sasmor,Henri;IsisPharmaceuticals Carlsbad, CA 92008 lo:50 Break Igor V.; Krutchinsky, WOC 1I:10 Studies of Non-Covalent Interactions by Time-of-Flight Mass Spectrometry; *Chemushevich, AndrewN.; Ens,Werner;Standing,KennethG.; Universityof Manitoba,WinnipegManitobaCanadaR3T 2N2 WOC 1I:30 Non-Covalent Protein Interactions and H/D Exchange Reactions on Target characterized by UV-MALDI-MS; *Glocker,Michael0.; Jetschke, MartinaR.; Bauer,Sebastian H.J.; Volz, Jurgen;Przybylski,Michael;University KonstanzChemistryDept.POBox5560M73 1,D-78434KonstanzGermany WOC 11:50 Interfacing BIA with MALDI Mass Spectrometry; *Krone,Jennifer;Nelson,Randall;Dogruel,David; Williams, Peter;Granzow,Russ;Arizona StateUniversity 12:10 LunchBreak,Workshops, Posters WOC 4:30 MS/MS as a valuable tool for determining the sequence specificity of DNA-interactive agents.; Iannitti, Paula; Wickham,Geoff; Boschenok, Jacqui;Hick, Larry A.; *She&MargaretM.; Universityof Wollongong,Wollongong, NSW Australia WOC 4:50 Probing the influence of mutations on the stability of a cluster-ferredoxin complex; R migy, Herv ; Jaquinod,Michel; Ptillot, Yves;Hurley,John;Gagnon,Jean;*Forest,Eric; lnstitutdeBiologieStructuraleCEA-CNRS,Grenoble,France WOC 5:lO In situ monitoring by ESI-MS of reactions of drugs with zinc finger proteins; *Hathout,Yetrib; Fabris,Daniele; Fenselau, Catherine;StructuralBiochemistryCenter,Universityof MarylandBaltimoreCounty WOC 5:30 Investigation of DNA-Protein Interactions Relevant to DNA Repair; *Harms,Amy C.; Severs,JoanneC.; Liu, Chuanliang; Pasa-Tolic, Ljijana;Hofstadler,StevenA.; Smith, RichardD.; PacificNorthwestNationalLaboratory, Richland,WA 99352 Wednesday ION TRAPS: FUNDAMENTALS AND APPLICATIONS, Steje Lammert, presiding WOD 09:30 Towards an Understanding of Resonant Excitation in a Quadrupole Ion Trap; *March, RaymondE.; Lausevic, Mila; Splendore,Maurizio;Liere,Philippe;Tabet,Jean-Claude; Department of Chemisry,Trent University, Peterborough, ON, Canada, K9J 7B8 WOD 09:50 A first-order model for collision-induced dissociation in the Paul ion trap; *Goeringer,Douglas;McLuckey,Scott; OakRidgeNationalLaboratory,OakRidge,TN 3783l-6365 WOD IO:10 Methods for Cooling Trapped Ions or Electrons; *Li, Guo-Zhong;Guan,Shenheng; Marshall,Alan G.; National HighMagneticFieldLab,FloridaStateUniv., Tallahassee, FL WOD IO:30 The Effect of Heavy Gases on the Dissociation Patterns of Peptide Ions in a Quadrupole Ion Trap; *Vachet, RichardW.; Glish,GaryL.; Universityof NorthCarolina,ChapelHill
PRELIMINARY
WOD
WOD WOD
WOD
WOD WOD WOD
PROGRAM
381
IO:50 Break I I : IO Improvements in Performance of MALDYQuadrupole Ion Trap Designed for Biological Applications.; *Doroshenko, Vladimir M.; Cotter, Robert J.; Pharmacology, Johns Hopkins University Medical School, Baltimore MD I I :30 Technical Aspects of Matrix-assisted Laser Desorptionltonization Ion Trap Mass Spectrometry; l Qin, Jun; Chait, Brian; The Rockefeller University, 1230 York Ave., New York, NY 10021 I I:50 Reactions of Multiply Charged Biological Cations with Singly Charged Anions in the QITMS; *Stephenson Jr., James L.; McLuckey, Scott A.; Oak Ridge National Laboratory, Oak Ridge, TN 12: IO Lunch Break, Workshops, Posters 4:30 Fundamental Studies of Ion Injection and Trapping of Electrosprayed Ions on a Quadrupole Ion Trap; *Quarmby, Scott T.; Yost, Richard A.; *Schwartz, Jae C.; Syka, John E. P.; University of Florida, Gainesville, FL I Finnigan MAT, San Jose, CA 450 Characterization of Combinatorial Chemical Libraries by Ion Trap-Tandem Mass Spectrometry; *Henion, Jack; Nedved, Michael; Habibi, Sohrab; Cornell University, Ithaca, NY 510 Many-particle computer simulations of ion motion in Paul and ICR ion traps; *Mitchell, Dale W.; Smith, Richard D.; Pacific Northwest National Laboratory, Richland WA 5:30 Non-linearity of ion oscillations in ion trap: the key to the mystery of ultra-high mass resolution; *Makarov, Alexander; General Physics Institute, Moscow, Russia
Wednesday ION STRUCTURE AND ENERGETIC!& Sreven Kass,presiding WOE
09:30
WOE
IO:10
WOE
IO:30
WOE
IO:50 I I : IO
WOE
I I:30
WOE
I I :50
WOE
12: IO 4:30
WOE
4:50
WOE
5: IO
WOE
5:30
Wednesday WOF 09:30 WOF
IO: IO
WOF
IO:30
WOF
IO:50 I 1: 10
WOF
I I :30
WOF
l1:50
WOF
12: IO 4:30
WOF
4:50
Conformations of Exotic Species in the Gas Phase: An Intersection of Experiment and Theory; *Bowers, Michael T.; Wyttenbach, Thomas; Lee, Seong Hoon; Department of Chemistry, University of California at Santa Barbara Negative Ion Photoelectron Spectroscopy of Transition Metal Trimers; *Leopold, Doreen; Simson, Alex; Green, Susan; University of Minnesota Photoelectron Spectroscopy of Small Cluster Anions; Dipole Bound, Ground State Systems; Hendricks, Jay; declercq, Helen; Lyapustina , Svetlana; Fancher, Chuck; Lippa, Tim; Collins, John; *Bowen, Kit; Johns Hopkins University Break The Proton Affinity and Absolute Heat of Formation of Trifluoromethanol; Chyall, Leonard J.; *Squires, Robert R.; Purdue University, Department of Chemistry, West Lafayette, IN 47907 Reaction Energetics: Nucleophilic Displacement and Proton Transfer; DeTuri, Vincent F.; Hintz., Paul A.; l Ervin, Kent M.; Department of Chemistry, University of Nevada, Reno Size and Structural Effects in the Energetics of Gas Phase Ion-Molecule Association Reactions; l McMahon, Terry; Hoffman, Tim; Department of Chemistry; University of Waterloo; Waterloo, Ontario; CANADA Lunch Break, Workshops, Posters Ion chemistry of protonated lysine and derivatives; *Harrison, Alex. G.; Yalcin, Talat; University of Toronto, Toronto, Canada M5S IAI Generation, Characterization, and Decomposition of Silanol Cations; Nygaard, Dawn; Wilcox, Bruce; *Jacobson, Denley; North Dakota State Univeristy, Fargo Photodissociation Spectroscopy and Dynamics of the N202- Anion; *Osbom, David; Leahy, David; Cyr, Douglas; Neumark, Daniel; University of California, Berkeley, and Lawrence Berkeley Laboratory Conformation of Gas-Phase Lysozyme Ions As Revealed by Surface-Impact Defects; *Sullivan, Patrick A.; Reimann, Curt T.; Axelsson, Jan; Quist, Arjan P.; Hakansson, Per; Roepstorff, Peter; Sundqvist, Bo U.R.; Division of Ion Physics, Uppsala University, Uppsala MASS SPECTROMETRY AND DNA ADDUCTS, Jackson Lay, presiding Quantitation of carcinogen-DNA adducts in humans: the role of mass spectrometry; *Hecht, Stephen S.; American Health Foundation DNA adducts vs protein adducts as carcinogen biomarkers in humans.; * Wishnok, John S.; MIT Division of Toxicology, Cambridge, MA 02 I39 Molecular dosimetry of DNA and hemoglobin adducts using mass spectrometry; *Swenberg, James; Christova, Nadia; Ranasinghe, Asoka; Scheller, Nova; Tretyakova, Natalia; Wu, Kuen-yu; Yen, Robert; University of North Carolina at Chapel Hill Break Molecular Dosimetry of Endogenous Carcinogens; ‘Chaudhary, Ajai K.; Kowalski, Eileen M.; Yeola, Suresh N.; Reddy, G. R.; Mamett, Lawrence J.; Blair, Ian A.; Vanderbilt University School of Medicine HPLC/ESI/MS May Be The Technique of Choice for the Analysis of Certain DNA Adducts.; Yen, Ten-Yang; Gueorgieva, Nadia; Scheller, Nova; Holt, Sharon; Swenberg, James A.; *Charles, M. Judith; Dept. Environ. Sci. & Eng., University of North Carolina at Chapel Hill Quantitation of endogenous ethenoguanine by GCIECNCDHRMS; l Scheller, Nova ; Ranasinghe, Asoka; Yen, TenYang; Gueorguieva, Nadia; Swenberg, James; University of North Carolina at Chapel Hill Lunch Break, Workshops, Posters Assessment of DNA Oxidative Damage by Quantification of 2-Methylglycerate from Thymidine Glycol; Naritsin, Dmitry; *Markey, Sanford P.; National Institute of Mental Health, Bethesda Detection of DNA Adducts by Electron Capture-MS; *Giese, R.; Naim, A.; Abushamaa, A.; Pillai, S.; *Samson, L. I2; Northeastern University and Harvard School of Public Health
382 .
4TH
ASMS
CONFERENCE
ON
MASS
SPECTROMETRY
.
WOF
5:lO
WOF
5:30
Application of Capillary Separation Methods Coupled to MS for the Analysis of DNA; l Vouros, Paul; Rindgen, Diane; Barry, John; Ding, Jianmei; The Bamett Institute, Northeastern University, Boston, MA Development of MALDI- and ES-FTICR for the Characterization of DNA Adducts; *Hettich, Robert; Stemmler, Elizabeth; Tang, Liang; Buchanan, Michelle; Hurst, Gregory; Oak Ridge National Laboratory
THURSDAY
ORAL SESSIONS
Thursday 8:30 Thursday ThOA 09:30
ThOA
IO:10
ThOA
IO:30
ThOA
IO:50 II:10
ThOA
I I:30
ThOA
II:50
ThOA
l2:lO 4:30
ThOA
450
ThOA
5:10
ThOA 5:30 Thursday
PLENARY
LECTURE
Prehistoric
Jean Clottes,French Ministry of Culture K. W. Michael Siu, presiding
Cave Art at Vallon,
FUNDAMENTALS OF ELECTROSPRAY, New Developments in Understanding and Exploiting Electrospray Ionization; *Smith, Richard D.; Tang, Keqi; Harms, Amy C.; Hofstadler, Steven A.; Anderson, Gordon A.; Udseth, Harold R.; Rockwood, Alan L.; Wu, Qinyuan; Pacific Northwest National Laboratory, Richland WA Fractionation during evaporation of ES droplets; *Fenn , John B.; Kiselev, Pavel; Resell, Joan; Virginia Commonwealth University, Richmond, Virginia 23284-2006 F The Electrolytic nature of Electrospray; *Van Berkel, Gary ; Zhou, Feimeng; Aronson, Joseph; Oak Ridge National Laboratory Break A Novel Three-Electrode System for Rapid Electrochemistry I Electrospray Mass Spectrometry; *Cole, Richard B.; Lu, Wenzhe; Xu, Xiaoming; Department of Chemistry, University of New Orleans, New Orleans, LA 70148 Ion mobility/mass spectrometric investigation of electrospray ions; *Guevremont, Roger; Siu, K.W. Michael; Ding, Luyi; Inst. Nat. Measurement Stds., National Research Council of Canada, Ottawa Quantitative Characteristics and Matrix Effects of Electrospray Mass Spectrometry; *Ho, Zhanying Stacy; Shou, Zhenyu; Browner, Richard F.; School of Chem. & Biochem. , Georgia Tech, Atlanta, GA 30332-0400 Lunch Break, Workshops, Posters Protein Charge Distribution Studies - From Droplet in Air to Ion in Vacuum, * *Thomson, Bruce; Sciex, Concord, Canada Assessment of hydrogen bonding contributions in a gas phase protein by mass spectrometry.; *Hunter, Christie L.; Mauk, A. Grant; Douglas, Don J.; Dept. of Biochemistry, University of British Columbia, Vancouver, Canada On the origin of spray current pulsations in ES MS; Juraschek, Reinhard; Paulig, Rolf; Bohmer, Martin; *ROllgen, Franz W.; Inst. of Physical Chemistry, University of Bonn New Electrospray Sauce: Low Pressure Electrospray; *Sheehan, Edward; Willoughby, Ross; Chem-Space Associates MASS SPECTROMETRIC CHARACTERIZATION OF SYNTHETIC POLYMERS,
Kevin Owens,presiding ThOB
09:30
ThOB
09:50
ThOB
IO:10
ThOB
IO:30
ThOB
IO:50 I I:10
ThOB
I I :30
ThOB
I I:50
ThOB
12: IO 4:30
ThOB
4:50
ThOB
5: IO
ThOB
5:30
MALDI-MS of Polymeric Materials; *Kassis, Camille M.; Belu, Anna M.; DeSimone, Joseph M.; Linton, Richard W.; Lange, Gary W.; Friedman, Robert M.; University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3290 Thin Film MALDI Matrix Loading for Water Insoluble Compounds; *Milberg, Richard; University of Illinois, School of Chemical Sciences, Urbana, IL Analysis of Low-Molecular Weight Polymer Blends by MALDlI Time-of-Flight Mass Spectrometry; *Hanton, Scott D.; Parees, David M.; Willcox, Dale A.; Goldschmidt, Robert; Owens, Kevin G.;; Air Products & Chemicals, Inc., Allentown, PA I8 I95 Polymer Analysis by MALDI - Rapid Molecular Weight and Chemical Modification Data; Wu, Kuang Jen; *Odom, Robert; Charles Evans & Associates Break The use of MALDI in the characterisation of polymers with broad molecular weight distributions.; *Scrivens, Jim; Yates, Hilary; Jackson, Tony; Rumbelow, Steve; Fawcett, Joanne; Critchley, Glen; Deery, Michael; Jennings, Keith; ICI Research Centre Characterization of Synthetic Polymers by FT-ICR Mass Spectrometry; l Pitsenberger, Cynthia C.; Danis, Paul 0.; Amster, I. Jonathan; The University of Georgia FTICR-MS characterisation of (co-)polymers; *Heeren, Ron M.A. ; O’Connor, Peter B.; Duursma, Marc C; van Rooij, Gerard J.; van der Hage, Erik R.E. ; de Koster, Chris G. ; Boon, Jaap J.; FOM-Institute for Atomic and Molecular physics, Amsterdam, The Netherlands Lunch Break, Workshops, Posters Tandem Electrospray MS for Assessment of Copolymer Composition; *Cook, Kelsey; Tuinman, Al; Haddix, Martin; Bennett, Kevin; Johnson, Jeremi; University of Tennessee-Knoxville Coupling Gel Permeation Chromatography to MALDI Mass Spectrometry; l Fei, Xun; Murray, Kermit; Emory University, Atlanta MS characterisation of fresh and aged natural and synthetic varnishes used for paintings.; *Boon, Jaap J.; van den Berg, Klaas Jan; van der Hage, Erik R.E.; van der Doelen, Gisela A.; O’Connor, Peter B.; Heeren, Ron M.A. ; de la Rie, Rene; FOM Intitute for Atomic and Molecular Physis Primary Thermal Degradation Mechanisms in Polyimides; *Grayson, Michael; McDonnell Douglas Corporation
PRELIMINARY
383
PROGRAM
Thursday
CELLULAR
ThOC
9:30
ThOC
IO:10
ThOC
IO:30
ThOC
IO:50 II:10
ThOC
I 1:30
ThOC
I I:50
ThOC
12:lO 4:30
ThOC
450
ThOC
5:lO
ThOC
5:30
RECOGNITION
AND SIGNAL
TRANSDUCTION,
Mark F. Bean, presiding
Investigation of T-Cell Receptor Induced Signal Transduction Pathways Using Electrospray MS; +Aebersold. R.; Figeys,D.; Gu, M; Ducret, A:; van Oostveen, i.; Bures, E. J.; Wange, R. LI; Sameion, L. E.;~Un&ersit of Washington, Seattle Understanding the Role of Protein Phosphorylation in Signal Transduction with the aid of MS; *Annan, Roland; Huddleston, Micheal; Carr, Steven; SmithKline Beecham Pharmaceuticals PSD Sequencing of Novel Invertebrate Gonadotropin Releasing Hormone Peptides from Tunicate; *Craig, A.G.; Fischer, W.H.; Powell, J.F.F.; Reska-Skinner, SM.; Park, M.; Rivier, J.E.; Sherwood, N.M.; The Salk Institute, La Jolla Break Monitoring Changes in Calcium-Induced Conformational Changes in Recoverin by ESI-MS; *Johnson, Richard; Neubert, Thomas; Walsh, Kenneth; Hurley, James; Department of Biochemistry, University of Washington, Seattle, WA Sequencing MHC Class I Kb Peptides Isolated from Mouse EL-4 Cells by Membrane PC-CE-MS(MS); +Tomlinson, Andy J.; Jameson, Stephen; Naylor, Stephen; Mayo Clinic Identification of Novel Sites of Phosphorylation of ScglO,A Neuronal Homologue of Stathmin; *Kassel, Daniel B.; Grenningloh, Gabriele; DiPaolo, Gilbert; Antonsson, Bruno; CombiChem, Inc., 9050 Camino Santa Fe, San Diego, CA 92121 Lunch Break, Workshops, Posters Structural Characterization of Non-Peptide Antigens: Is Presentation Paradigm Different?; *Reinhold, Vernon N.; Reinhold, Bruce B.; Porcelli, Steven A.; Moody, Branch; Brenner, Michael B.; Boston University Medical School, Boston, MA 02 I 18 Accurate Peptide Sequencing for Cloning and Homology Searching; Wilm, Matthias; Shevchenko, Andrej; *Mann, Matthias; European Molecular Biology Laboratory (EMBL) ESI-MS evaulation of the post-translation modifications to histones upon induction of apoptosis; *Lipton, Mary S. Weir; Thrall, Brian D.; Horan, R. Clinton; Springer, David L.; Edmonds, Charles G.; Pacific Northwest National Lab Protein Identification with Tandem Mass Spectrometry and SEQUEST; *Yates, John R.; McCormack, Ashley L.; Eng, Jimmy K.; Schieltz, David M.; University of Washington, Seattle, WA
Thursday
FAST SEPARATIONS/MASS
ThOD
09:30
ThOD
IO:10
ThOD
IO:30
ThOD ThOD
IO:50 I 1: IO I I:50
ThOD
12: 10 4:30
ThOD
4:50
ThOD
5:lO
ThOD
5:30
Coupling Matrix Assisted Laser Desorption Ionization Mass Spectrometry to Liquid Separations; *Murray, Kermit; Emory University, Atlanta On-line High Speed Countercurrent Chromatography I ESIMS in Natural Product Chemistry;*Kong, Zhengrong; Rinehart, Kenneth; Milberg, Richard; School of Chemical Sciences, University of Illinois at Urbana-Champaign Novel Strategies For The Coupling Of Capillary Electrochromatography With Mass Spectrometry; *Lane, Steve; Boughtflower, Robert; Paterson, Glare; Underwood, Tim; Morris, Michael; GlaxoWellcome, Gunnels Wood Road, Stevenage, Hertfordshire, SGI 2NY, UK Break *Sacks, Richard; University of Michigan Advances in High-Speed Gas Chromatography; High Speed, High Throughput CC/MS Using Time-of-FlightMass Spectrometry with Time Array Detection; *Gardner, Ben; Holland, John; Michigan State University Lunch Break, Workshops, Posters Fast CC and comprehensive 2DGC coupled to HRMS and TOFMS for environmental toxicant analysis; *Barr, John R.; Green, Vaughn; Grainger, James; Patterson, Donald G., Jr.; Holland, Jack; Gardner, Ben; Beaudry, Randy; Centers for Disease Control and Prevention On-line Detection of Fast Chromatographic Events by Electrospray Ionization Time-of-Flight MS; *Gulcicek, Erol E.; Andrien, B.; Banks, J. F.; Boyle, J. G.; Dresch, T.; Haren, P.; Whitehouse, C. M.; Analytica of Branford, Inc. Some Observed Phenomena of Linear Quadrupoles under Fast CC/MS Conditions; *Grimm, Casey C.; Lloyd, Steven W.; Southern Regional Research Center, USDA-ARS, New Orleans, LA Combatibility of Fast CC with TOFMS: How FastCanWe Go?; *Parry, Ritchard; Artaev, Viatcheslav B.; McNitt, Kevin; Schmitz, Dennis; Phinney, Mary Jane; Mitchell, Joel; LECO Corporation, St. Joseph, MI
Thursday ThOE 09:30 ThOE
ThOE ThOE ThOE ThOE
SPECTROMETRY, Jack Holland, presiding
FOURIER TRANSFORM MASS SPECTROMETRY, Evun Williums,presiding
Electrospray/FT’ICR SORI and H/D Exchange Studies of Isolated Gas-Phase Protein Conformers; Bolanos, B.J.; Stevenson, E.; Arkin, C.R.; *Laude, D.A.; The University of Texas at Austin 09:50 Structural Analysis of Polysaccharides and Peptides by MALDI FT-ICR MS; l Solouki, Touradj; Reinhold, Bruce, B.; Costello, Catherine E.; O’Malley, Matthew; Guan, Shenheng; Marshall, Alan, G.; National High Magnetic Field Lab, Florida State Univ., Tallahassee FL IO: 10 A Top Down Approach to Sequence Refinement of Large Proteins.; *Kelleher, Neil; Fridriksson, Einar; Valaskovic, Gary; Aaserud, David; Guan, Ziqiang; McLafferty, Fred; Cornell University, Ithaca, NY IO:30 Blackbody Infrared Radiative Dissociation : From Dissociation Energetics to Structural Elucidation; *Price, William; Schnier, Paul; Williams, Evan; University of California, Berkeley IO:50 Break 1 I:10 Non-destructive, broad-band FT detection using dc dipolar excitation in a quadrupole ion trap; *Cooks, R. G.; Soni, M.; Frankevich, V.; Nappi, M.; Bui, H.; Santini , R. E.; Amy, J. W.; Purdue University I I:30 Optimization of ion trapping and mass measurement in FT-ICR mass spectrometry; Bluhm, Brian; *Gillig, Kent; Russell, David; Texas A&M University College Station
384 .
44TH
ASMS
CONFERENCE
ON
MASS
SPECTROMETRY
*
ThOE
1150
Characterization
12: 10
*Buchanan, Michelle; Hettich, Robert; Lunch Break, Workshops, Posters
4:30
ThOE
LD-FTMS
450
ThOE
5: IO
ThOE
5:30
Thursday ThOF
09:30 09:50
Real-Time
Prather,
ThOF
IO:50 I I:10 I
W.; University
ThOF
of Individual
Kimberly;
University
Drews, Frank; of Duesseldorf, Newark,
Instrumentation Coggiola, Break
Real-Time
DE
Kaufmann,
Lunch
Break,
5:lO
ThOF
5:30
Kenneth;
SRI International
Oak Ridge
National
and Multivariate
*Spengler, Johnston,
Bernhard;
Data Analysis; Hinz,
Institute
of Laser
Murray;
Wexler,
Anthony;
Zhouzheng;
Young,
Steve;
*Reilly, Peter; Ridge, TN
Oak
in Contaminated Arto
*Shi, Park
Menlo
Particulates;
Laboratory,
Medicine,
University
Ciieray,
Rainer;
Yang,
Becker,
MO;
Lake Sediment by a Small Low-Field
K.; Blatchley
III, Ernest
of Trace Analysis by Ion Trap MS/MS; *Lynn, Workshops,
of
R.; Kenttamaa,
Jr., Bert C.;; Mississippi
Hilkka
Chris;
Whitten,
William;
FT/ICR
MS.;
I.; Purdue
University,
State University.
Posters
The Study of PAH Transformations
on Single Micrometer-Sized
Particles Using TOF-SIMS;
*Fister, Thomas; Evans & Associates Gary; Wright, Static SIMS Studies of Organophosphate Adsorption on Metal Oxides; *Ingram, Jani; Groenewold, Randy; Appelhans, Anthony; Idaho National Engineering Laboratory, Idaho Falls, ID On-Line and Near-Real Time of CC/MS Based Analytical Techniques in Field and Process; *McClennen, William; Cole, Paul; Meuzelaar, Henk; Arnold, Neil; Center for Micro Analysis, University of Utah, Salt Lake City, Utah Capillary ElectrophoresislElectrospraylMass Spectrometry of the Herbicides Paraquat and Diquat; Xinbei, Song; *Budde, William L.; U. S. Environmental Protection Agency, Cincinnati, OH 45268 Strossman,
ThOF
Raimund;
Aerosol Characterization;
Hermann;
MS/MS of Organic Airborne
Optimization
*Noble,
Riverside
19716
Wollnik,
Michael;
12: IO
4:50
TN 3793 I-6365
Particle in Ambient Aerosols in Riverside, California;
Lange, Ronald; Germany
for Tropospheric
Mike;
I I:50
ThOF
Oak Ridge,
Monolayers
of California,
I :30 Fate Studies of 3,3’-Dichlorobenzidine
4:30
Ions into an FTICR MS;
Laboratory,
MASS SPECTROMETRY, Kim Prather, presiding
*Nyman, Marianne C.; Perez, James; Nyman, West Lafayette, IN ThOF
National
of California,
Analysis of Aqueous Aerosols; *Neubauer,
Ramsey, ThOF
Oak Ridge
Single Particle Analysis by On-line Bipolar Laser Mass Spectrometry
10: 10 On-Line IO:30
Liang;
of Self-Assembled
Russell
Characterization
Delaware ThOF
Everett,
ENVIRONMENTAL
Klaus-Peter; University ThOF
Tang,
on Gold; *Wilkins, Charles L.; Scott, Jill R.; Yao, Riverside Eugene; Rakov, Sergey, Futrell, Analysis of FTMS Signal Waveforms for Multi-electrode Detection ; ‘Nikolaev, Jean; The Institute for Energy Problems of Chemical Physics, Moscow, Russia Characterization of ESI-FTICR Performance at Low Magnetic Fields; *Gorshkov, Michael V.; Wu, Qinyuan; Udseth, Harold R.; Anderson, Gordon A.; Smith, Richard D.; Pacific Northwest National Laboratory Accurate Mass Measurements By Using Multiple Ionization Techniques Simultaneously with FTIMS.; *Castoro, John; Winger, Brian; FTMS, Inc., 6416 Schroeder Rd., Madison WI, 5371 l-2424. Ingrid;
Christopher; ThOF
Ion Guide for Transfer of Electrosprayed
Study of Air Oxidation
Jie; Fritsch,
ThOE
of an Electrostatic
Greg;
Summers,
Stacie;
Linton,
Richard;
MONDAY
Odom,
Robert;;
Charles
POSTERS
HISTORY OF MASS SPECTROMETRY INSTRUMENTATION Abstracfs are arranged alphabetically byfirsr author MPA
The State of the Art of Time-of-flight Louis
MPA
MO
Mass Spectrometer
in 1958; *Grayson,
Evolution of the Consolidated D.; BDM-Oklahoma,
Engineering
Inc./NIPER,
Corporation
Bartlesville,
McDonnell
Douglas
Corporation,
21-1 IO Double Focusing Mass Spectrometer;
Small Mass Spectrometers manufactured by C.E.C.; *Judson, Charles; A Classic Mass Spectrometer (CEC 21-1lOB) Modified for Continued
MPA
The Literature
**Jarmeson,
W. David;
Department
Universty
of Kansas,
Yough, Vitality
Ronald
Lawrence,
KS, 66045 *Ramaley, B3H 4J3
and Productivity;
of Chemistry, Dalhousie University, Halifax, NS, Canada, *Sparkman, 0. David; 0. David Sparkman & Associates
of Mass Spectrometry;
*Grigsby,
Oklahoma
MPA MPA
Louis;
Michael;
63166
ION SOURCE AND MS INSTRUMENTATION Abstracts are arranged alphabetically byfirst author MPB
The Design of a New Direct Probe Inlet for a Mass Spectrometer; Services,
MPB
Application Colby,
MPB
Inc.
Ringoes,
of SIMION
Steven
M.;
6.0 to Filament Design for Mass Spectrometer
Manura,
A computer simulation
*Baker,
Christopher;
Manos,
John;
Scientific
Instrument
Christopher
W.;
NJ John;
Scientific
Instrument
of the current distribution
Services,
Inc.
Ionization
Ringoes,
in an electron multiplier.;
Sources.; *Baker,
NJ *Batey,
Jonathan;
Liezers,
Martin;
VG
Elemental MPB
Modification Griffin,
MPB
Measuring Berkeley
MPB
of an HP 5972 MSD for use in Direct Sampling of Volatile Organic Compounds
Timothy;
Bauer,
MIMS
Charge on Individual National
New
York
Technology
Electrospray
Incorporated, Ions (z > 425);
Palm Bay, Florida *Benner, W. Henry;
Fuerstenau,
in Water; l Bauer, Stephen
Scott;
D.; Lawrence
Laboratory
An Improved Multiple Ronald;
Janice;
ADC Transient
University
Medical
Recorder Data System for MALDI School
MS; Carroll,
James;
Chen,
Xiangjun;
*Beavis,
St
PRELIMINARY
MPB MPB MPB MPB MPB MPB MPB MPB MPB MPB MPB MPB MPB MPB MPB
MPB
PROGRAM
385
Ion Imaging Using a Charge Injection Device (CID) Detector: *Christopher, Steven J.; Marcus, R. Kenneth; Clemson University, Department of Chemistry, Clemson, SC 29634-1905 A Conceptual Pulsed Heavy Ion Gun for MeV Particles based on Neutron Generator Technology; *Fries, David; O’Malley, Rebecca; **Browning, J.F.; U. South Florida Marine Science Dept & Chemistry Dept, Tampa FL A new electrosprny source designed for an HP-5985 ES-MS; *Kiesel, Jennifer R.; Habibi-Goudarzi, Sohrab; Depperman, Kevin L.; Duffin, Kevin L.; Monsanto Corporate Research, Monsanto Co., St. Louis, MO 63 198 The Development of an Enhanced Microchennel Plate Detector for Time-of-Flight Mass Spectrometry; *Laprade, Bruce; Fuchs, Wolfram; Lincoln, Brian; Galileo Electra-Optics, Galileo Park, PO Box 550, Sturbridge, MA 01566 Tunable Energy Electron Monochromator Interface to a Sector Instrument; + Laramee, James; Cody, Robert; Deinzer, Max; Dept. of Agricultural Chemistry, Oregon State University, Corvallis, OR Atmospheric Pressure Microwave Induced Plasma as an Ionization Source for Mass Spectrometry; *Moini, Mehdi; University of Texas at Austin, Austin Comparison of EI and MAB ionization for exact mess measurement.; * Mousselmal, Moussa; Faubert, Denis; Evans, Michael J.; Bertrand, Michel J.; University of Montreal, Montreal Performance of e new needle configuration in e Finnigan electrospray ion source: *Musser, Steven; Sphon, James; Instrumentation and Biophysics Branch, CFSAN, FDA, Washington, DC 20204 Soft Ionization In the Quadrupole Ion Trap for Chemical Type Analysis; *Roussis, S.G.; Cameron, A.S.; Imperial Oil, Samia Research Centre, Sarnia, Ontario, Canada, N7T 7Ml A New Simple and Divers Interface for Microcolumn Separation API-MS; ‘Sjoberg, Per J. R.; Markides, Karin E.; Dept. of Analytical Chemistry, Uppsala University An Electron Multiplier With On-Board Preamplifier For Detecting Ion Signals Ranging Over Nine Orders; +Stresau, Richard W.; Hunter, Kevin L.; ETP Electron Multipliers, 3 1 Hope St., Ermington, Australia 21 I5 Accurate mess measurement at low resoution by using electrosprey-MS on a quadrupole instrument.; *Tyler, Andrew N.; Clayton, Eddie; Green, Brian N.; Harvard Chemistry Department, Cambridge, MA Performance of a Submicroliter Per Minute Electrosprey Probe; *Whitehouse, Craig; Banks, J. Fred; Whitehouse, Glenn; Analytica of Branford Inc. Design and Performance of a Microscale ES1 Source for High Resolution Measurements; *Wulser, Kurt; Smith, David L.; Department of Chemistry, University of Nebraska, Lincoln, NE 68588-0304 Liquid Ionization Mass Spectrometry of Clusters Containing Water in Gas end Liquid Phases; *Yarning, Li; **Takashi, Tashiro; Kotaro, Hama; Masahiko, Tsuchiya; Yokohama National University, Tokiwadai, Hodogayaku, Yokohama, 240 Japan Laser Droplet Mass Spectrometry; *Zhou, Jie; Lee, Terry; **Mahoney, John; Beckman Research Institute of the City of Hope, Duarte, CA 91010
FUNDAMENTAL STUDIES Abstracts are arranged alphabetically byfirst author MPC MPC MPC MPC MPC MPC MPC MPC MPC MPC MPC MPC MPC MPC MPC
Ab Initio Calculations of Proton Affinities. Ionization Potentials. end Electron Affinities of PAHs: l Betowski. Leon: ’ Aue, Donald; Beeloo, Edward; U.S. Environmental Protection Agency, Las Vegas, NV 89193 Entropy Effects Upon the Dissociation of Metal Ion Bound Dimers of Biomolecules; *Cerda, Bias A.; Wesdemiotis, Chrys; Chemistry Department, The University of Akron, Akron Ohio 44325-3601 A PM0 theory of ion-molecule collision and electron-transfer rates; *Dougherty, Ralph; Dept of Chemistry, Florida State University, Tallahassee FL 32306-3006 Ionization Energies and CID Fragmentation Patterns of Distorted Porphyrins; *Ferguson, James A.; Yost, Richard A. (I); Quirke, J. Martin E (2); University of Florida Chemistry Department, Gainesville, FL S(OH)2 as a Stable Oxidized Sulfur Intermediate by Neutralization-Reionization Mass Spectrometry; *Frank, Aaron; Sadilek, Martin; Ferrier, Jordan; Turecek, Frantisek; University of Washington SOZH as a Stable Oxidized Sulfur Intermediate by Neutralization-Reionization Mess Spectrometry; *Frank, Aaron; Sadilek, Martin; Ferrier, Jordan; Turecek, Frantisek; University of Washington Diagnostics of Microwave Plasmas of C2H4: Li+ ion attachment mass spectrometry; *Fujii, Toshihiro; Kim, Ho Seob; **Kishi, Hiroshi; National Institute for Environmental Studies, Tsukuba, Ibaraki 305, JAPAN The mess spectrometric detection of very large clusters/polymers in molecular beams; *Greene, Frank; Mid-Continent Research, Lake Quivira, KS Antiaromatic Ions: A Flowing Afterglow Study; Han, Sangdon; Arrowood, Tina; Sathers, Sandra; Eckert-Maksic, Mirjana; *Kass, Steven; University of Minnesota Structures, Bonding end Reactions of 2c-3e Sulfur-Sulfur, Halogen-Halogen and Sulfur-Halogen Systems; *Illies, Andreas; James, Mary A.; Nichols, Linda; Auburn University, Auburn Energetics and higher order structure of multiply protonated peptides in the gas phase; *Kaltashov, Igor; Fenselau, Catherine; Dept. of Chem., Univ. of Maryland Baltimore County, Baltimore, MD 21228 Ionization of Some Aliphatic Alcohol Molecules with Kinetic Energy on Surfaces; *Kishi, Hiroshi; **Fujii, Toshihiro; Oyama National College of Technology, Oyama, Tochigi 323, JAPAN Experimental and Computational Studies of Double Ionization of Alkynes.; *Martin, Rachel L; Harris, Frank M; Andrews, Stuart R; Parry, David E; Mass Spectrometry Research Unit, University of Wales Swansea, Swansea, UK. Whet Does TPEPICO Say About Ionized Methyl Acetate ?; Mazyar, Oleg; *Mayer, Paul M.; Baer, Tomas; Chemistry Dept., University of North Carolina at Chapel Hill, Chapel Hill The Unimolecular Chemistry of Ionized B(OCH3)3; *Mayer, Paul M.; Baer, Tomas; Chemistry Department, University of North Carolina, Chapel Hill, N.C.
.
386 * MPC MPC MPC MPC MPC MPC MPC MPC MPC MPC MPC MPC MPC MPC MPC MPC MPC MPC MPC MPC
4lTH
ASMS
CONFERENCE
ON
MASS
SPECTROMETRY
Gas Phase Acidities Using Density Functional Theory: Is It Reliable? Is It Cheap?; Merrill, Grant; *Kass, Steven; University of Minnesota Cation-Ether Complexes in the Gas Phase: Bond Dissociation Energies and Equilibrium Structures; *More, Michelle; Glendening, Eric; Hill, Sue; Ray, Doug; Feller, Dave; Armentrout, P. B.; Chemistry Department, University of Utah, Salt Lake City Comparison of Nanosecond and Femtosecond Multiphoton Ionization Processes; l Moritz, Fritz; Heinicke, Ralf; Grun. Carsten; Grotemeyer, Jilrgen; Insttitut fur Physikalische Chemie, Universitat Wurzburg Determination of Metal Ion Binding Affinities of the DNA Bases by Guided Ion Beam Mass Spectrometry.; *Rodgers, M. T.; Armentrouf P. B.; University of Utah, Salt Lake City Metastable H3S by Neutralization-Reionization Mass Spectrometry; *Sadilek , Martin; Turecek, Frantisek; University of Washington, Seattle Neutralization-Photoionization Mass Spectrometry for the Study of Hypervalent Radicals; *Sadilek , Martin; Turecek, Frantisek; University of Washington, Seattle Ab Initio QCISD(T) Calculations for the Ground Potential Energy Surface of He3+; Satterwhite, M. F.; *Gellene, Gregory; Dept. of Chem. & Biochem. Texas Tech Univ., Lubbock, TX 79409-1061 Ab Initio Studies of Polyiodide Anions; Sharp, Stephanie; *Gellene, Gregory; Dept. of Chem & Biochem., Texas Tech University, Lubbock, TX 79409-1061 The influences of ion activation and thermalization effects on reaction rate constant in the ITMS.; Steiner, Valerie; Liere, Philippe; **Jennings, Keith; March, Raymond; Tabet , Jean-Claude; Universitt P. et M. Curie Proton Affinity and Association Thermochemisty of Cyclic Anhydrides; *Szulejko, Jan; McMahon, Terry; Department of Chemistry, University of Waterloo, Waterloo, Ontario, CANADA Combined HPMS, Metastable Ion and Collision Activation Study of Organo-Silyl Cations and Adducts; *Szulejko, Jan; **Hop, Comelis; Saulys, Dovas; Gaines, Donald; McMahon, Terry; Department of Chemistry, University of Waterloo, Waterloo, Ontario, Canada The Gas Phase Ion/Molecule Chemistry of Distonic Radical Cations revealed by FT-ICR; *Troude, Valerie; Audier, Henri; Leblanc, Danielle; Mourgues, Philippe; DCMR. CNRS URA 1307, Ecole Polytechnique, F-91 I28 PALAISEAU Thermochemical Properties of bifunctional linear and cyclic products; *Troude, Valerie; Audier, Henri; Bouchoux, Guy; **McMahon, Terrance B.; Szulejko, Jan E.; DCMR, CNRS URA 1307, Ecole Polytechnique, F-91 I28 PALAISEAU Unimolecular reaction dynamics from kinetic energy release distributions; Urbain, Pascale; *Leyh, Bernard; Remacle, Fran oise; Lorquet, Jean-Claude; Department of Chemistry, Li ge University, B.4000 SART-TILMAN Production of Molecular Ar Ions in Associative Ionization at a Pressure of Several Torr; *Vinogradov, P. S.; Borisenko, D. M.; Veretennikov, I. N.; Institute of Energy Problems of Chemical Physics, Russian Academy of Sci. Collision-induced emission spectroscopy of solitary ions; *Wesdemiotis, Chrys; Wiedmann, Fred A.; Wu, Jianglin; Chemistry Department, The University of Akron, Akron, Ohio, 443253601 Measurements of the Lifetimes of Ion-Molecule Collision Complexes; * Williamson, D.H.; Knighton, W.B.; Grimsrud, E.P.; Montana State University Bozeman, MT Hypervalent Ammonium Radicals by Neutralization-Reionization of Protonated DABCO; *Wolken, Jill; Nguyen, Viet Q.; Turecek, Frantisek; University of Washington Agostic and steric effects on atomic and polyatomic cation affinities of pyridines; *Wang, Philip; Ma, Shuguang; Cooks, Graham; Eberlin, Marcos; Guzzo, Fabio; Purdue University Inverted region behaviorin gas phase electron-transfer reactions; *Xu, Ming; Li, Weiqun; Marshall, Alan; Guan, Shenheng; Dougherty, Ralph; Dept of Chemistry, Florida State University, Tallahassee FL 30306-3006
TRAPPED IONS Abstracts are arranged alphabetically byjirst author MPD MPD MPD MPD MPD MPD MPD MPD MPD MPD
Evaluation of Transition Metal Ion and Ammonium Ion Complexation by Pharmaceuticals in a QITMS; *Alvarez, Erwin; Vartanian, Victor; Brodbelt, Jennifer; The University of Texas at Austin, Austin, Texas Size-Selective Collision Activated Dissociation of Transition Metal Ion/Polyether Complexes in a QIT; *Alvarez, Erwin J.; Wu, Hui-Fen; Brodbelt, Jennifer S.; The University of Texas at Austin, Austin, Texas Increased Sensitivity for Quadrupole Ion Traps by Rapid Removal of RF; *DeGnore, Jon P.; Yost, Richard A.; Jones, Jon A.; University of Florida, Gainesville High Kinetic Energy CIMS in the Quadrupole Ion Trap - Effect of Axial Modulation; *Dorey, R. Cameron; Dobbs, Sheri; University of Central Arkansas, Conway, AR Fragmentation of Sodium Cationized Molecules of Cyclic Peptides in MALDYQuadrupole Ion Trap MS.; *Doroshenko, Vladimir M.; Cotter, Robert J.; Pharmacology, Johns Hopkins University Medical School, Baltimore MD Description and characteristics of a novel FT-Ion Trap Mass Spectrometer; *Frankevich, Vladimir; Soni, Manish; Nappi, Mario; Cooks, R. Graham; Santini, Robert E; Amy, Jon W; Purdue University, West Lafayette, IN The effect of ion trap field parameters on the ion/molecule reactions of o-dichlorobenzene; Franklin, Tony M.; *Todd, John F.J.; Chemistry Department, University of Kent , Canterbury, Kent, CT2 7NH, UK. Using an Ion Trap for LC/MS Analysis of Benzodiazepines; l Goodley, Paul C.; Fjeldsted, John C.; Hewlett-Packard Co., 1601 California Ave., Palo Alto, CA 94304 Practical Considerations for Successful API-LCMS of Pharmaceuticals Using a Quadrupole Ion Trap; *Goodley, Paul C.; Fjeldsted, John C.; Hewlett-Packard Co., 1601 California Ave., Palo Alto, CA 94304 Progress in the Development of a Transportable QUISTOIUreTOF-MS for Air Monitoring; *Grace, Louis 1.; Chambers, David M.; Thomas, Stan W.; Andresen, Brian D.; Lawrence Livermore National Laboratory
PRELIMINARY
MPD
Analysis of Compounds J.; Brodbelt,
MPD MPD
Jennifer
MPD MPD MPD MPD MPD MPD MPD MPD MPD MPD MPD MPD MPD
MPD MPD MPD MPD MPD MPD MPD MPD MPD MPD
Interest by Solid Phase Microextraction
of Texas
at Austin,
Quadrupole
Gregoire;
E., March;
*Jean-Claude,
Comparison Fox,
Analytical
Tabet;
of quadrupole Alvin;
Fox,
**Raymond University
of South
Department
Ion Trap Universite
and ion trap CC-MS-MS
Karen;
Performance
Merriweather, MPD
of Pharmaceutical
S.; The University
Negative Ion Studies with a Conventional
Mark; MPD
387
PROGRAM
Wise,
Marcus
B.; Oak
Austin, Texas Mass Spectrometer; Jean-Charles, Pierre et Marie Curie (Paris)
Brad
Mathurin;
Sebastien,
for the detection of muramic acid in airborne
Carolina,
School
of an Ion Trap Mass Spectrometer
Roosevelt;
and Ion Trap CC/MS; *Hall,
of Chemistry,
Ridge National
of Medicine,
Columbia,
Using Air as the Buffer Gas;
dust; *Krahmer, South Carolina +Lammert, Stephen A.;
Laboratory
in an Ion Trap Mass Spectrometer; l Lausevic, Trent University, Peterborough, ON, Canada K9J 7B8 Positive Ions and Negative Ions of Toxaphene Formed in an Ion Trap; *Lausevic, Mila; Splendore, Maurizio; Jiang, Xuewu; March, Raymond E.; Department of Chemistry, Trent University, Peterborough, ON, Canada K9J 7B8 Effects of Rapid Change in Trapping Parameter Due to Reaction; l Lausevic, Zoran; Londry, Frank A.; March, Raymond E.; Department of Chemistry, Trent University, Peterborough, ON, Canada K9J 7B8 Ion Coupling Effects and Mass Shifts in Ion Trap Mass Spectrometry; MO, Wenjun; *Todd, John J F ; Chemistry Department, University of Kent, Canterbury, Kent CT2 7NH, UK Helmut; Huels, Wilfried; Structure Elucidation by MS/MS/MS on a Hybrid Tandem Mass Spectrometer; *Muenster, Schroeder, Ernst; Finnigan MAT GmbH, D-28 I97 Bremen, Germany Three-Dimensional Representations of Ion Motion in the Quadrupole Ion Trap; *Nappi , Mario; Cleven, Curtis D.; Soni, Manish H.; Bui, Huy A.; Weil, Carsten; Cooks, R. Graham; Purdue University, West Lafayette IN 47907 Characterization of Photographic Couplers using an API-Ion Trap Mass Spectrometer; *Nichols, William; **HabibiGoudarzi, Sohrab; Henion, Jack; Eastman Kodak, Analytical Technology Division, Rochester, New York Tandem-in-time ion trap MS II: Isotope dilution quantification of amphetamines in human urine.; *Phinney, Curtis S.; Welch, Michael J.: National Institute of Standards and Technology, Gaithersburg, MD 20899-0001 Frequency-Sweep Ion Trap Mass Spectrometry; *Price, John M.; Gorshkov, Michael V.; Barlow, Stephan E.; Ray, Douglas; Pacific Northwest National Laboratory, Richland, WA 99352 Instrumental Development and Characterization of a Linear Ion Trap Time-of-Flight Mass Spectrometer; l Purves, Randy; Gabryelski, Wojciech; Li, Liang; University of Alberta, Edmonton Theoretical Study of The Ring Closure of 1,7-Octadiyne, I-Octen-7-yne and 1,ZOctadiene; *Robbins, Ronny; Jensen, James; Berg, Fred; U.S. Army, Aberdeen Proving Ground, Edgewood Area, APG, MD Sensitivity Improvement of NanoSPRAY-Ion Trap MS; *Schubert, Michael; Wang, Yang; Franzen, Jochen; BrukerFranzen Analytik GmbH, Fahrenheitstr. 4, D-28359 Bremen Self Chemical Ionization of Organophosphorus Esters in an Ion Trap; *Slivon, Laurence; Carleton, Linda; Dejarme, Lindy; Battelle Memorial Institute Maurizio; March, Raym0nd.E.; Londry, A Simulation Study of Resonant Excitation in a Stretched Ion Trap; *Splendore, **Perrier, Pierre; Andre, Jacques; Department of Chemistry, Trent University, Peterborough, Frank.A.; Morrison, Richard.J.S.; ON, Canada, K9J7B8 A Comparative Study of On-Axis and Asymptotic Ion Injection in the Quadrupole Ion Trap; Stephenson Jr., James L.; *Asano, Keiji G.; Goeringer, Douglas E.; McLuckey, Scott A.; Oak Ridge National Laboratory, Oak Ridge, TN Instrumentation for the Reaction of Multiply Charged Cations with Singly Charged Anions in the QITMS; *Stephenson Jr., James L.; McLuckey, Scott A.; Oak Ridge National Laboratory, Oak Ridge, TN Application of SWIFT for Elucidation of Reaction Pathways in the Quadrupole Ion Trap; l Vartanian, Victor, H.; Shen, Jim; Brodbelt, Jennifer, S.; The University of Texas at Austin Experimental Investigation of Space Charge Effects on Ion Distributions in a Quadrupole Ion Trap; *Ventura, M.C.; Laude, D.A.; The University of Texas at Austin Improvements to Electrospray-Ion Trap MS for the Detection of Drug Residues; *Voyksner, Robert; Lee, Heewon; Analytical & Chemical Sciences, Research Triangle Institute, RTP, NC 27709 Comparison of mass resolution between resonance and non-linear resonance ejection at gz=2/3; *Wang, Mingda; Wells, Gregs; Varian Chromatography System, 2700 Mitchell Dr, Walnut Creek, CA 94598 Simulation Study Of Electrical Ion Cooling; l Weil, Carsten; Cleven, Curtis D.; Nappi, Mario: Cooks, R. Graham; Purdue University, West Lafayette A TRAPTOF-Mass Spectrometer for Investigations of Unimolecular Reactions.; Weickhardf Christian; Wilhelm, Ulf; Milller, Matthias; l Grotemeyer, Jtirgen; Institut fur Physikalische Chemie, Universitat Wtlrzburg Systems, Walnut Creek CA Mass Scanning In An Asymmetrical Trapping Field; *Wells, Greg; Varian Chromatography Tracie L.; Yost, Richard A.; University of Selective Cleavage of Peptide Bonds Using Ion/Molecule Reactions; *Williams, Florida, Gainesville, FL A Comparison
of Experimental
Mila;
Zoran;
Lausevic,
March,
Procedures for Resonamt Excitation
Raymond
E.; Department
of Chemistry,
ENVIRONMENTAL ANALYSIS Abstracts are arranged alphabetically byjirst author MPE
A Rapid Screening Technique Brown,
MPE
Stephen
Quantitative **McGown,
MPE
M.; Berard,
for Identification
David
F.; DowElanco,
Analysis of Quinclorac Steven;
ALTA
Analytical
Indianapolis,
*Balcer,
Jesse L.;
IN
and Degradates by Ionspray LC-MS/MS;
*Bethem,
Robert;
Jordan,
Jeannine;
Laboratory
Structural
Analysis of Algal Transformation
SmithKline
Beecham
Pharmaceuticals,
of Spinosad Photolysis Products Using ESUMSIMS;
King
Products Using LCIESYMS; of Prussia,
PA
*Brum,
Jeffrey;
Hsu, Leo; Orvos,
David;
.
388 * MPE MPE MPE MPE MPE MPE MPE MPE MPE MPE MPE MPE
44TH
ASMS
CONFERENCE
ON
MASS
SPECTROMETRY
Trace Level Determination of Pesticides by On-Line Extraction and LC with APcl tandem MS.; *Hogenboom, Ariadne; Slobodnik, Jaroslav; Vreuls, Rene; **Rontree, John; van Baar, Ben; Niessen, Wilfried; Brinkman, Udo; Study of Oxidation Products of Dyes by Electrospray-Ion Trap Mass Spectrometry; *Lee, Heewon; Voyksner, Robert; Analytical & Chemical Sciences, Research Triangle Institute, RTP, NC 27709 Quantitation of Soil Metabolites Utilizing Narrow Bore LClMSlMS on Quadrupole Mass Spectrometers; *M&own, Steven; Delgado, Nelson; Wemess, Steven; BASF Corporation, Research Triangle Park Determination of an Experimental Fungicide and Metabolites in Soil; *Perkins, John; Jiang, Jennifer; Henion, Jack; **Jordan, Jeannine; M&own, Steve; Advanced BioAnalytical Services, Inc., Ithaca Identification of Surfactants in Real Samples by HPLC-IS-MS and MS-MS; ‘Raffaelli, Andrea; Pucci, Sergio; Campolmi, Laura; Salvadori, Piero; Centro Studio CNR Macromolecole Stereordinate ed Otticamente Attive APCUMS Analysis of Hydrolysis and Oxidation Products of the Chemcial Agent VX; *Rohrbaugh, Dennis; U.S. Army Edgewood RD&E Center, APG, MD 2 10 I O-5423 Investigating the Metal Binding Properties of Dissolved Organics in the Environment Using LCIESI-MS; **Ross, Andrew; *Ikonomou, Michael G.; Orians, Kristin; Institute of Ocean Sciences, Sidney BC, Canada The Analysis of Explosives Constituents and Metabolites using Electrospray and APCI LCIMS; *Schilling, Alexander; Hewlett Packard Co., Naperville, III Comparison of APCI and ES1 - LClMS for the Determination of Carbamates; *Shoemaker, Jody A.; Behymer, Thomas D.; U.S. Environmental Protection Agency, Cincinnati APCI LCYMS Analysis of High Molecular Weight PAH Isolated from Complex Environmental Samples; *Smith, Richard W.; Marvin, Chris H.; McCarry, Brian E.; Department of Chemistry, McMaster University, Hamilton, ON, L8S 4M1, CANADA Qualitative and quantitative determination of aromatic sulfonates using capillary LC-MS; *Suter, Marc J.-F.; Riediker, Sonja; Giger, Walter; Swiss Federal Institute for Environmental Science and Technology, EAWAG Pesticide Analysis Using Sonic Spray Ionization Mass Spectrometry; Yukiko, Hirabayashi; Atsumu, Hirabayashi; *Yasuaki, Takada; Minoru, Sakairi; Hideaki, Koizumi; Central Research Laboratory, Hitachi Ltd., Kokubunji, Tokyo 185, QA/QC
AND PROCESS
MONITORING
Abstracts are arranged alphabetically byjirst author MPF MPF MPF MPF MPF MPF MPF MPF MPF MPF MPF MPF MPF
MPG MPG MPG
The Application of Molecular Beam Mass Spectrometry to the Problem of Plastics Recycling; Elam, Carolyn; *Evans, Robert; Meglen, Robert; Tatsumoto, Kuniyasu; National Renewable Energy Laboratory (NREL), Golden, CO Identification of Pharmaceutical Particulate Contaminants by Pyrolysis MS using a DE1 Probe; *Forbes, Robert A. ; Lilly Research Laboratories, Eli Lilly and Company, Clinton, lN 47842 On line MS to monitor a new process of mineralization of organic liquid nuclear waste.; *Franck, Rouppert; French Atomic Energy Commission - Marcoule - France Spectral Resolution of Structural Hydrocarbons: A Process Mass Spectrometry Application; *Haddix, Martin; Cook, Kelsey; Bennett, Kevin; University of Tennessee-Knoxville Development of a MIMS method for on-line analysis of industrial waste waters and air emissions; **Honkanen, Tapio; *Ketola, Raimo; Mansikka, Timo; Kostiainen, Risto; Kotiaho, Tapio; Komppa, Veikko; Wickstrhm, Kim; Vahervuori, Hilkka; VTT, Chemical Technology, P.O. Box 1401, FIN-02044 VTT, Finland Direct Sampling APVTOFMS for the Determintaion of Trace Impurities in High Purity Process Gases; *Lee, Edgar; Wu, Mingin; Lippert, Andrew; Cox, Lee; Lee, Milton; Sensar Corporation MBMS Study of A Premixed Fuel-Rich Ethylene Flame; *Luo, Fei; Yeh, Lisa I; Exxon Research and Engineering Company, Annandale, NJ 08801 Study of Organic Matrix MI/MS using Alternative Membrane Materials; * Maden, Amy J.; Ficarro, Scott B.; Hayward, Mark J.; American Cyanamid - Princeton, NJ Improving Detection Limits of Clenbuterol by Upgrading the HP 5970; *Roy, Laura; **Jehnsen, Chris; Graves, Peter; Hamerly, Thomas; Detector Technology, Inc., Sturbridge, MA The evaluation of a benctop API LC-MS system for the determination of impurities in pesticides; *Shushan, Bori; **Yves, Le Blanc; PE-Sciex, 71 Four Valley Drive, Concord (Ontario) L4K 4V8, Canada MBMS Studies of Thermal Decomposition and Catalytic Steam Reforming Reactions of Oxygenates; *Wang, Dingneng; **Montane, Daniel; Chomet, Esteban; National Renewable Energy Laboratory, Golden, Coloardo, USA Classifying analgesics by batch of origin using pyrolysis MS with pattern recognition; *Wilkes, Jon G.; Akbar, Safdar; Barry, Thomas L.; FDA, National Center for Toxicological Research, Jefferson, AR 72079-9502 Characterization of degradates and process impurities in Merck products; *Yin, Winnie; Harmon, Paul; Reed, Robert; Tyrrell, R. Jeff; Merck & Co. Inc., West Point, PA SEPARATIONS/MS TECHNIQUES - APPLICATIONS Abstracts are arranged alphabetically byfirst author SFClionspray-MS for the Analysis of Chiral Pharmaceuticals.; *Baker, Timothy R.; Pinkston, J. David; Hentschel, Rosemary; Procter & Gamble Pharmaceuticals Determining the Site(s) of Protein-Inhibitor Complexes Through the Use of On-Line LCIESI-MS; *DeJohn, Dana; Loo, Joseph; Parke-Davis Pharmaceutical Research, Ann Arbor, MI Capillary ElectrochromatographylMass Spectrometry: Separation and Detection of DNA Adducts.; *Ding, Jianmei; Vouros, Paul; Bamett Institute, Northeastern University, Bonston, MA 02115
PRELIMINARY
MPG
The Direct Analysis of Fuels by Supercritical Evan;
MPG
Nero,
MPG
PO Box
Whitlock,
Laboratories,
Pharmaceutical
Applications
Division
Churchwell,
of Brevetoxin
Applications Paterson,
MPG
Distributions
MPG MPG MPG MPG MPG MPG MPG MPG MPG
MPG
Chen,
1.; Thompson,
*Fisher, Dixie; North Carolina HPLC-MS; *Gao, Quanyin;
Triangle
Using
Morgan,
Daniel;
Park,
l *Freiha,
MO 65265
Harold
by HPLC-ECD-APCI/MS
C.; Doerge,
Ionization;
Daniel
*Hayes,
analysis; *Hansen,
R.; National
Roger;
Center
Parke-Davis
for Toxicological
Pharmaceutical
in Natural “Red Tide” Algae Blooms by LC-Electrospray-MS;
S.; Pierce,
Richard
Industry; *Lane,
GlaxoWellcome,
, David
H.; Cole. Richard
Gunnels Kirsten;
Steve; Morris, Road, Stevenage,
Wood
by High-performance L.; Lampi,
B.; Department
*Hua, University
of
Michael; Boughtflower, Robert; Hertfordshire, SGI 2NY, UK
Liquid Chromatography
Department
of Chemistry,
of Chemistry,
I Mass Spectrometry;
University
*Ma,
of Nebraska-Lincoln,
Spectrometry Techniques; *Mireault, Pascal; Bertrand, M.J.; University of Montreal Directly Coupled Packed Column SFC With APCI/MS; *Morgan, Daniel ; Norwood, Daniel; Fisher, Dixie; Moseley 111, M. Arthur; Glaxo Wellcome Inc., Research Triangle Park, NC 27709 Optimizing Speed, Sensitivity and Resolution in LClMS Analysis of Pharmaceuticals; *Nugent, Kerry; Stoney, Ken; **Mylchreest, lain; Wheeler, Kevin; Michrom BioResources, Inc. Improved response in Ionspray MS with packed-column SFC and SF-assisted nebulization; *Pinkston, J. David; Baker, Timothy R.; The Procter & Gamble Company, Miami Valley Laboratories, Cincinnati, OH On-line LC-NMR-MS: a useful technique for obtaining the maximum information from mixtures; *Pullen, Frank; Swanson, Alistair; Newman, Michael; Burton, Keith; Pfizer Central Research UK The Role Of LClMS in the Identification of Electrochemically Generated Products; *Regina, Merle Corazon; BrajterToth, Anna; Department of Chemistry, University of Florida, Gainesville,FL3261 I Detection of the Presence of Diesel Fuel in Fire Debris; *Rodden, Elizabeth; Stone, Earle; Bach, Stephan; Streeper, Robert; The University of Texas at San Antonio Flow Injection and LC/MS of Food Lipids Using Electrospray; *Sanders, Robert; Tallmadge, Dan; Morsch, Thomas; The Procter & Gamble Company, Cincinnati, Ohio, US RP-IP HPLCIMSIMS Detection of Penciclovir and its Phosphorylated Derivatives; *Smymis, Elie, M.; Sacks, Stephen, L.; Burton, Roland; Wall, Richard, A.; Abbott, Frank; University of British Columbia, Vancouver, Canada. Capillary Supercritical Fluid Chromatography I Chemical Ionixation Mass Spectrometry of Carnauba Wax; *Via, James; Ludicky, Bob; Doster, Doug; Morton International, 1275 Lake Avenue, Woodstock, IL 60098 Detection of Nitrated Products in Cosmetic-Raw Material by LC/MS with an On-Line Photolysis Reactor; *Vollmer, David; Billadeau, Mark; Lay, Jack; Volmer, Dietrich; Nat’1 Center for Toxicological Research, 3900 NCTR Rd, Jefferson, AR Faubert,
MPG
Tim;
Smith, Jean B.; Smith NE 68588
Evaluation
Antibiotics
Dr., Mexico,
In The Pharmaceutical
Underwood,
Donald;
Company
Studies of Human Lens Beta-Crystallins Zhixiang; Lincoln,
MPG
Of CEClMS
Clare;
*Drinkwater,
A Practical Examination.;
Inc., Research
of SFClMS with Electrospray
Yousheng; Lu, Wenzhe; Henry, Michael New Orleans, New Orleans, LA 70 148 MPG
Wellcome
response of erythromycin
Mona
of Warner-Lambert
/ Mass Spectrometry;
12508
Products of Beta-Lactam
of the HPLC electrochemical Wenhong;
NY
Using LCIMS:
Glaxo
Inc., 5000 Christopher
Eugene B.; Luo, Research
Determination
Fluid Chromatography 509, Beacon,
A. Luke;
of Degradation
Biocrafi
Investigation
R&D,
Peak Purity Determination
Characterization
Research, MPG
Texaco
111, M. Arthur;
Bassam; MPG
Vincent;
Chromatographic Moseley
MPG
389
PROGRAM
of MAB as a selective Ion Source for Chromatography/Mass
Denis;
72209 Structural Yajuan;
Carrier,
Alain;
Mousselmal,
Moussa;
Analysis of Heat Shock Protein 27,000 by Capillary
Lubman,
David
M.; Department
of Chemistry,
MS; l Zheng,
HPLClESI
The University
of Michigan,
Kefei; Qian, Mark Ann Arbor, MI 48109
G.; Chen,
SEPARATIONS/MS TECHNIQUES - INSTRUMENTATION Abstracts are arranged alphabetically byjirst author MPH
Low pH Solvent Alternatives Kerry;
MPH
Wheeler, Levery,
Correlation
Hyphenation
Variable Davis,
SKI0
Yamane,
4TG,
Research
Truong,
Inc., Auburn,
Dave;
LC for Protein/Peptide
Nuwaysir,
in LC-MS;
of Peptides; *Baldwin,
*Clayton,
Lydia;
**Anacleto,
Eddie;
Morris,
Analyses; *Chen,
Joe; PE Sciex, Michael;
Zeneca
David
M.;
of the City
Baldwin,
Chemistry
Interface for Overcoming David;
Flow Electrospray Stahl,
Douglas;
Applied
of Hope,
Patricia;
MALDI Dept.
TFA-ion
Olson,
LCIMSIMS Swiderek,
Ling; McLean, Biosystems
Pharmaceuticals,
Emitter Geometry and Orifice Dimensions to Signal Quality; Institute
Hoai-Thu;
Sam; Nugent,
CA
Alderley
UK.
between HPLC and Liquid
Rachel; Games, Saskatoon, Sask. Mike;
BioResources,
Duarte,
Douglas;
Scios Nova
Suppresion Ashcroft,
Of Michigan.
Beckman
Mass Spectrometer; Ann Arbor.
in Electrospray Allison;
Research
*Guzzetta,
T.;
Andrew;
Institute,
of the Chromatographic
Institute
*He,
Ling;
of the City
Chen,
Xin;
Li,
MI
LCYMS of Peptides; l Hogge,
Plant Biotechnology
- Escape from the Tyranny Kristine;
Michael
Inc.
in an Ion trap/TOF
University
*Davis,
CA 91010
of an HP1090 HPLC into an automated capillary HPLC with LCMS applications;
X.; Lubman,
A Triaxial **Martin, Council,
MPH
Michrom
Combined with Capillary
Dave;
of On-line Microspray
Ling-Ling;
Michael MPH
DuPont,
Cheshire
D.; Beckman
Conversion Kang,
MPH
Steve;
Maccleslield,
Lee, Terry MPH
lain;
Routine use of cone-voltage fragmentation Park,
MPH
to TFA Solvents and Their Effect on HPLCIESI-MS
Mylchreest,
Micro IonSpray Mass Spectrometry Matthew; Division
MPH
Kevin;
of Hope
National
Lawrence; Research
Time Frame; *Lee, Terry;
.
390 MPH MPH MPH MPH MPH MPH MPH MPH MPH MPH
MPH MPH
MPH
44TH
ASMS
CONFERENCE
ON
MASS
SPECTROMETRY
Chsracterixation of Bacterial Proteins Using MALDI MS Following SDS-PAGE; +Liang, Xiaoli; Zheng, Kefei; Bai, Jian; Liu, Yan-Hui; Lubman, David M.; Department of Chemistry, The University of Michigan, Ann Arbor, MI 48109 Optimixation of TLClMALDI Coupling Protocol; *MehI, John, T.; Gusev, Arkady, 1.; Nicola, Anthony, J.; Hercules, David. M.; Vanderbilt University, Nashville, TN Applications of Automated Capillary-HPLCIElectrospray Mass Spectrometry; *Morris, Frank X.; Spreen, Russell C.; Zeneca Pharmaceuticals, Lead Discovery Dept., Wilmington, DE Development of Quantitative Analysis by TLCIMALDI; *Nicola, Anthony J.; Gusev, Arkady 1.; Hercules, David M.; Department of Chemistry, Vanderbilt University, Nashville, TN 37235 USA Electrospray Mass Spectrometry of Proteins Following Comprehensive Two-Dimensional HPLC; *Opiteck, Gregory; Jorgenson, James; Anderegg, Robert; University of North Carolina at Chapel Hill, Chapel Hill, North Carolina Quantitative Capabilities of LC/ESYFTICRMS; *Padley, Henry; Bashir, Sajid; Wood, Troy; State University ofNew York at Buffalo Separation and Detection of Cellular Proteins by HPEC-MS Method; *Rajamani, Uma; Prabhakaran, M.; Krishnamurthy, Thaiya; Biopolymer Facility, U. S. Army ERDEC, Aberdeen Proving Ground, MD Searching for Optimal Liquid Matrix Compositions for On-line LCIMALDI; *Russon, Larry; Golding, Rafael; Whittal, Randy; Li, Liang; Department of Chemistry, University of Alberta, Edmonton Automated on-line sample handling and analysis by Micro or Capillary LC prior to MS; *Salzmann, Jean-Pierre; van Soest, Remco E.J.; **Vissers, Johannes; Chervet, Jean-Pierre; LC Packings (USA) Inc., 80 Carolina Street., San Francisco, CA 94103 2D-PAGE, Capillary HPLClESIMS and MALDUMS for Structural Analysis of Proteins; **Seta, Kazuo; l Nakayama, Hiroshi; Shinkai, Fumiko; Isobe, Toshiaki; Kanai, Michiko; Hidenori, Ikezawa; Okuyama, Tsuneo; Biochemistry, Tokyo Metropolitan University Optimized Conditions For Negative Ion LC-ESMS To Enhance Detection of Peptides and Phosphopeptides; *Stoney, Ken; Baldwin, Sam; **Huddleston, Michael J.; Carr, Steven; Michrom BioResources, Inc., Auburn, CA Comparative Studies of LClMS and MS/MS Using FT-ICR, Quadruple and Sector Mass Spectrometry; *Xiang, Xinzhen; Dunphy, Richard; Leister, William; Burinsky, David J.; **Winger, Brian E.; Castoro, John A. ; The R. W. Johnson Pharmaceutical Research Institute Profiling of Bacterial Proteins and Recombinant Proteins by Capillary HPLCl MALDI MS; *Zheng, Kefei; Liang , Xiaoli; Qian, Mark G.; Chen, Yajuan; Lubman, David M.; Department of Chemistry, The University of Michigan, Ann Arbor, MI 48109 CARBOHYDRATES
Absfracfs are arranged alphabeficab’ybyfirst author MPI MPI MPI MPI MPI MPI MPI MPI MPI MPI
MPI MPI MPI MPI MPI
A Comparison of Low and High Energy CID for the Structural Characterization of Glycopeptides; *Alexander. Anthony ; Blackledge, James; Dodsworth, Dave; Bristol-Myers Squibb Co, Pharmaceutical Research Institute, Syracuse Application of Wavelet Transforms to Electrospray Spectra: Baseline Removal; * Barclay, V. J.; Bonner, R. F.; Thibault, P.; PE Sciex, Toronto Development of MALDI Method for the analysis of sulfate Oligosaccharides; *Dai, Yuqin; Whittal, Randy; Hindsgaul, Ole; Palcic, Monica; Li, Liang; Department of Chemistry, University of Alberta Separation and Detection of Isomers of Sucrose Derivatives by LC-MS; *Feng, Rong; Thomson, Michael; American Cyanamid Co., P.O. BOX 400, Princeton, NJ 08543 New Glycosylamine Derivatives for Sequence Analysis of Oligosaccharides by MALDI-MS and ESI-MS; *Gage, Douglas A.; Xu, Naxing; Huang, Zhi-Heng; Dept. of Biochemistry, Michigan State University, East Lansing, MI 48824 Overcoming Metastable Decay and Salts in Anionic Glycoconjugates by Delayed Extraction MALDI-TOF; *Gibson, B.W.; John, C.M.; Hines, W.M.; Falick, A.M.; University of Calilfomia, San Francisco MALDI-Tandem MS/MS of complex oligosaccharides examined with an orthogonal TOF analyser.; *Harvey, David J.; **Bateman, Robert H.; Green, Martin R.; Glycobiology Institute, Department of Biochemistry, University of Oxford. A new, fast approach for sequencing oligosaccharides by exoglycosidase digestion and MALDI-TOF MS; l Kilster, Bernhard; Naven, Thomas J. P.; Harvey, David J.; Department of Biochemistry; University of Oxford; Oxford, UK Preparing oligosaccharides from glycoproteins for MALDI MS: A comparison of different procedures; *Ktister, Bernhard; Harvey, David J.; Department of Biochemistry; University of Oxford, UK Tandem mass spectrometry for characterization of oligosaccharides from keratan sulfate; Masayuki, Kubota; Takashi, Hirano; Haruki, Niwa; *Mamoru, Ohashi; **Keiichi, Yoshida; Akira, Tawada; The University of Electra-Communications, Chofu, Tokyo 182, Japan Fragmentation of oligosaccharides on a linear TOF mass spectrometer using delayed extraction.; l Naven, Thomas J. P.; **Brown, Jeff.; Harvey, David J.; Glycobiology Institute, Department of Biochemistry, University of Oxford MALDUTOF Analysis of Neutral and Acidic Oligosaccharides. Is Quantitation Possible?; *Papac, Damon; Jones, Andy; Analytical Chemistry, Genentech, Inc. Analysis of peracetylated carbohydrates by Cf-252-PDMS utilizing matrix ion-molecule reactions; *Pittenauer, Ernst; Binder, Wolfgang; Schmid, Walther; **Allmaier, Gtlnter; Institute for Analytical Chemistry, University of Vienna, A-1090 Vienna Considerations of Fidelity in Glycoform Distributions Using MALDI and ES1 Mass Spectrometry; *Reinhold, Bruce B.; Ye, Song; Helin, Jari; Reinhold, Vernon N.; Costello, Catherine E.; Boston University Medical School, Boston, MA 02118 Microcapillary LC/Electrospray Characterization of Saccharides; *Shahgholi, Mona; Ohorodnik, Susan; Callahan, John; Naval Research Laboratory
PRELIMINARY
MPI
MPI MPI MPI
PROGRAM
391
’ MALDI-TOF MS of Oligosaccherides Derivatized with 4-Aminobenzoic Acid Z-(Diethylnmino)ethyI Ester; l Takao, Toshifumi; Tambara, Yanet; Nakamura, Akihiro; Yoshino, Ken-ichi; Shimonishi, Yasutsugu; Institute for Protein Research, Osaka University, Suita, Osaka, Japan ESI-MS/MS of Co(2+)-Coordinated Lewis X, Lewis a, and A-Trisaccharide; +Taw, Felicia; Brimmer, Steven; Leary, Julie; Dept. of Chemistry, University of California, Berkeley; Berkeley CE-MS analysis of carbohydrates derived from glycoproteins; Sensitivity and mobility characteristics; l Thibault, Pierre; Locke, Steven; Institute for Marine Biosciences, 141 I Oxford St., Halifax, N.S., Canada Assessing the structural equivalence of complex recombinant glycoproteins; *Yu, Wen; Mazsaroff, Istvan; Vath, James; Rouse, Jason; Scoble, Hubert; Genetics Institute, Andover DRUG METABOLISM - QUALITATIVE STUDIES
Abstracts are arranged alphabetically byfirst author MPJ MPJ MPJ MPJ MPJ MPJ MPJ MPJ MPJ
MPJ MPJ MPJ MPJ MPJ MPJ MPJ MPJ MPJ MPJ MPJ MPJ MPJ MPJ MPJ MPJ
Determination of the metabolism of the Anti Helicobactor Pylori agent CP-233,504 by HPLCIIIVIAPIMS; *Avery, Michael; Needham, Shane; Colizza, Kevin; Shepard, Richard; Brighty, Katherine; Fouda, Hassan; Pfizer INC Groton, CT Electrochemical oxidation of pramipexole.; *Baczynskyj, Lubomyr; Althaus, John S.; VonVoigtlander, Philip F.; Phannacia & Upjohn, Inc. Characterization of Pt-Complex Impurities by LC-ESI-MS/MS on a Sector/OA-TOF Hybrid Instrument.; *Blackledge, James; Dodsworth, David; Alexander, Anthony; Bristol-Myers Squibb PRI Characterization of Metabolites of CP-118,954 in Rat Urine and Bile by LCIMSIMS; *Cui, Donghui; Prakash, Chandra; Central Research Division, Pfizer Inc., Groton, CT 06340, USA Characterization of CYP-450 Derived PCHS-II Metabolites of Arachidonic Acid Using LC EN/MS/MS; *Gamer, Carlos 0.; Belas, Frank; Blair, Ian; Vanderbilt University Nashville, TN HPLCIEWMSIMS Studies on the Metabolic Fate of the Macrolide Antibiotic CP-163,505; *Gauthier, Jeff; Cole, Mark; Harran, Lydia; Linhares, Mike; Pfizer Inc HPLC-APCUMS analysis of cyproheptadine and azatadine and their microbial metabolites; *Hansen, Eugene B.; Churchwell, Mona I.; Zhang, Donglu; Cemiglia, Carl E.; Doerge, Daniel R.; National Center for Toxicological Research, Jefferson, AR Metabolism of Mycophenolate Mofetil: Structural elucidation of both MPA and morpholine metabolites.; *Haroldsen, Peter; **Chu, Nancy; Roche Bioscience: Metabolism, Bioanalysis and Phannacokinetics Metabolism of spectinomycin in cattle following subcutaneous injections of 3H-spectinomycin sulfate; *Homish, Rex; Arnold, Thomas; Gilbertson, Terry; Roof, Ryan; Wiest, John; **Davison, Kenneth; Pharmacia & Upjohn, Inc., Kalamazoo MI ESI/LC/MS Determination of Degraded Penicillin and Cephalosporin Antibiotics; *Kim, Jin Young; Yoo, Jong Shin; Korea Basic Science Institute MSn to Investigate Metabolite Structures using Triple Quadrupole and Ion Trap Mass Spectrometers; *Kleintop, Brent; Lim, H.K.; Chan, Kelvin; Sisenwine, Samuel; Wyeth Ayerst Research, Princeton, NJ 08543 HPLC/RAM/ESI/MS/MS Studies on the Metabolic Fate of the Anxiolytic Agent CP-93,393; *Luther, Elbridge; Cole, Mark; Soliman, Victor; Baxter, James; Fouda, Hassan; Pfizer Inc Interpretation of mass spectra of in vitro metabolites of vitamin D and its chemical analogs; *Makin, Hugh LJ; **Jones, Glenville; Trafford, David JH; Schroeder, Neil J; Calverley, Martin J; London Hospital Medical College, London El 2AD, UK Human liver microsomal metabolism in vitro of D-23129, a new anticonvulsant candidate; *McNeilly, Patrick; Anderson , Lawrence; Torchin, Cynthia; Kapetanovic, Izet; Kupferberg, Harvey; Strong, John; Food and Drug Administration, Rockville MD, USA Urinary and Plasma Metabolites of LY300164 in Human, Monkey, Dog, Rat, and Mouse by LCIMSIMS; *Murphy, A. T.; Gillespie, T. A.; Eckstein, J. A.; Swanson, S. P.; Eli Lilly and Company, Indianapolis In Vivo Formation of Ibuprofen Cholesterol Esters; *Nelson, Carolyn; Ellis, Bronwyn; Lohrer, Franzi; **Tattam, Bruce; Day, Richard; Williams, Ken; St. Vincent’s Hospital, Sydney Rapid screening of Taxol metabolites by LC-ESI-MS; *Peon, G.K.; Wade, J.; Bloomer, J.; Clarke, S.; Maltas, J.; SmithKline Beecham Pharmaceuticals, The Frythe, Herts Differentiation of Regioisomeric Hydroxylated Metabolites of CP-93,393 by Ionspray LC-MS/MS.; *Prakash, Chandra; Soliman, Victor; Central Research, Pfizer Inc., Groton, CT 03440 Reactivity of Benoxaprofen Glucuronide with Human Serum Albumin; *Qiu, Yongchang; Benet, Leslie; Burlingame, Alma; Dept. Pharm. Chem., University of California, San Francisco Use of LC/MS/MS and Column Switching for the Characterization of In Vitro Metabolites of SK&F 207499; *Schaefer, William; Dixon, Frank; Boppana, Venkatta; Ayrton, Andy; Sozio, Randall; SmithKline Beecham Pharmaceuticals, King of Prussia Identification of Zopolrestat Dog Metabolites by Microbore HPLC/Ionspray Tandem Mass Spectrometry; *Schneider, Richard; Inskeep, Phil; Fouda, Hassan; Central Research Division, Pfizer Inc, Groton, CT 06340 Electrospray LC/MS with Radioactivity Detection of In Vitro Metabolic Reaction Mixtures; *Solsten, Thomas; **Ridley, Will; Mehrsheikh, Mohammed; Monsanto Company Corporate Research, St. Louis Inhibition of Aldehyde Dehydrogenase by Disulfiram Analogs; *Veverka, Karen A.; Johnson, Kenneth L.; Tomlinson, Andy J.; Lipsky, James J.; Naylor, Stephen; Mayo Clinic, Rochester, MN 55905, USA Mass Spectrometric Identification of 5,12-Dihydroxy Eicosatetraenoic Acid Metabolites; *Wheelan, Pat; Murphy, Robert C.; Natl. Jewish Center for Immunology and Respiratory Medicine API III (Ionspray)-MS and MS/MS Analysis of Conjugated Topiramate Metabolites in Animals and Humans; *Wu, Wu-Nan; McKown, Linda; Streeter, Anthony; Takacs, Adrienne; R. W. Johnson Pharmaceutical Research Institute
392 .
44TH
ASMS
CONFERENCE
ON
MASS
SPECTROMETRY
* MPJ
MPJ MPJ MPJ
In Vitro Metabolism of Thalicarpine, An Antitumor and Antimicrobial Alkaloid, in Rat Hepatic SP; Wu, Wu-Nan; *McKown, Linda; R. W. Johnson Pharmaceutical Research Institute API III (Ionspray)-MS and MS/MS Analysis of In Vitro Metabolites of Bepridil (VASCOIW); Wu, Wu-Nan; l McKown, Linda; R.W. Johnson Pharmaceutical Research Institute, Spring House, PA Structural studies of mitomycin C analogue - human serum albumin adduct by MALDUMS; *Yasuzawa, Tom; Tomer, Kenneth; National Institute of Environmental Health Sciences, Res. Tri. Pk., NC Biotransformation of dynorphin A (l-17) in vivo in rhesus monkey blood studied by MS; *Yu, Jim; **Butelman, Eduardo R.; Woods, James H.; Kreek, Mary Jeanne; Chait, Brian T.; The Rockefeller University, New York, NY
LASER DESORPTION - FUNDAMENTALS Abstracts are arranged alphabetically byfirst author MPK MPK MPK MPK MPK
MPK MPK MPK MPK MPK MPK MPK MPK MPK MPK MPK MPK
MPK
MPK MPK MPK
Metastable Decomposition Study of Nltro-PAH in a Reflecting Time-of-Flight Mass Spectrometer.; *Bezabeh, Dawit Z.; Allen, Todd M.; Jones, A. Daniel; Kelly, Peter B.; University of California Davis, Davis, CA 95616, USA Energy Transfer Bottleneck in Matrix-Assisted Laser Desorption Revisited; Bencsura, Akos; Sadeghi, Mehrnoosh; *Vertes, Akos; George Washington University, Department of Chemistry Examining Charge State Distributions of Large Biomolecules Using MALDI-TOF; *Campo, Karen K.; Edmondson, Ricky D.; Russell, David H.; Texas A&M University, College Station A Delayed-Extraction Time-of-Flight Mass Spectrometer with a MALDI Source; *Chen, Xiangjun; Carroll, James; Beavis, Ronald; New York University Wavelength and Pulselength Dependence of IR-Matrix-Assisted Laser DesorptionlIonization Processes; *Cramer, Rainer; Haglund, Jr., Richard F.; Hillenkamp, Franz; Department of Physics and Astronomy, Vanderbilt University, Nashville, TN VUV Single Photon Post Ionization for Laser Desorption Mass Spectrometry.; *de Vries, Mattanjah S.; Hunziker, Heinrich; Baumann, Reinhard; IBM Almaden Research Center, San Jose, CA95120-6099 A Study of Sample Preparation Techniques for MALDI by X-ray Photoelectron Spectroscopy; Dingley, David C; *Humphrey, Paul; Smith, Alan J; Kratos Analytical, Barton Dock Road, Manchester, M41 7LD, UK. Comparison of Positive and Negative Peptide Ion Post Source Decay by MALDI-TOF MS; *Jai-nhuknan, Jaran; Cassady, Carolyn; Miami University, Oxford, Ohio Scanning laser power while acquiring MALDI spectra - Does prompt fragmentation occur at high power?; *Lavine, Gary; Allison, John; Michigan State Univeristy, East Lansing Fragmentation in MALDI-TOF Mass Spectra of some Calix[J]indoles.; *Lidgard, Ray; McConnell, Darryl; Black, David; Kumar, Naresh; Duncan, Mark; Biomedical Mass Spectrometry Unit, University of NSW, Sydney, Australia. Accuracy and precision of mass measurement in MALDI-MS with infrared lasers; *Menzel, Christoph; Berkenkamp, Stefan; Strupat, Kerstin; Hillenkamp, Franz; Institute for Med. Physics and Biophysics, University of Muenster, Germany Laser ablation of frozen matrices: surface processes and clusters formation.; *Nikiforov, Sergey M.; Sartakov, Boris G.; **George, Mike W.; Alimpiev, Sergey S.; Podolsky, Boris S.; General Physics Institute, Moscow, Russia Key Roles of Solvent Miscibility and Evaporation Rate in MALDI-TOF MS of Synthetic Polymer Samples; *Schoenfeld, Dean; University of Florida, Gainesville, FL 3261 I Mechanism of Ionisation by Cation Attachment in MALDI; *Scrivener, Elaine; Maloney, Darren R; Haddleton, David M; Eason, Michael; Fong, Karen; Derrick, Peter J; University of Warwick Investigation of gas phase process of MALDI-MS using a scintilation detector; *Stahl-Zeng, Jianru; Karas, Michael; Hillenkamp, Franz; Institute for Med. Physics and Biophysics, University of Muenster, Germany MALDI Internal Energy Transfer Studies Utilizing Molecular Modeling; *Sumner, Lloyd W. ; Huang, Yong; Russell, David H.; Texas A&M Univ., Laboratory for Biological Mass Spec., College Station, TX Further Resolution Improvements in Linear Matrix-Assisted Laser Desorption/Ionization TOF MS; *Weinberger, Scot; **Li, Liang; Komfeld, Richard; Whittal, Randy; Russon, Larry; Kaplun, Yevgeny; Donlon, Edward; Chemical Analysis Division, The Hewlett Packard Company, Palo Alto A Method for Metastable-ion Analysis in a Reflecting TOF Instrument with Precursor Ion Selection; *Westmacott, Garrett R.; Ens, Werner; Spicer, Victor L.; Standing, Kenneth G.; Dept. of Physics, Univ. of Manitoba, Winnipeg, Canada, R3T 2N2 Study of Mass Measurement Accuracy of a Time-Lag Focusing MALDI TOF Mass Spectrometer; * Whittal, Randy; Russon, Larry; ** Weinberger, Scot; Li, Liang; Department of Chemistry, University of Alberta Understanding the Basics and Enhancing Mass Resolution for MALDI-TOFMS; * Wu, Kuang Jen; Odom, Robert; Charles Evans & Associates Redwood City, CA 94063 Radial Velocity Distributions of Ions Ejected by Laser Desorption; l Zhang, Wenzhu; Chait, Brian T. ; The Rockefeller University, 1230 York Ave., New York, NY 10021
SPRAY IONIZATION - APPLICATIONS Abstracts are arranged alphabetically byfirst author MPL MPL MPL
Application of MicroIonSpray Techniques to the Analysis of Small Volumes of Complex Samples; *Anacleto, Joseph; **Chen, Ling; PE Sciex, Concord Ontario, Canada On-line dialysis and trace-enrichment coupled with HPLC and API-Mass Spectrometry; *B&h, Francis; Buergin, Eva; Hersperger, Rene; Bovermann, Guenter; Sandoz Pharma Ltd, Basle, Switzerland The Rapid Identification of Metabolites by Mass Spectrometry; *Banner, Ron; LeBlanc, Yves; **Macrae, Paul; PE Sciex Instruments, Toronto, Canada
PRELIMINARY
MPL
393
PROGRAM
Identilication
of an eminoglycoside
degrndnnt
in drug product by LC-ESEMS
and flow injection-MS/MS;
*Caesar,
JohnP.; Buxton, PeggyA.; Waraszkiewicz, SigmundM.; Astra USA, Inc. MPL
Identification
of a boron complex impurity
in SR233377 drug substance manufacture;
l Chowdhury,Swapan,K.;
Gonyea,George;Byard, Stephen;SanofiWinthrop,Inc. MPL MPL MPL MPL MPL MPL MPL MPL MPL MPL MPL MPL MPL MPL MPL MPL MPL MPL MPL MPL
Determination of acyclovir and guanine by microbore HPLC with confirmation by APCI.; l Cyr, Terry Donald; Kourany-Lefoll,Elly; HealthProtectionBranch,DrugsDirectorate,Bureauof DrugResearch Identification of Bioactive Peptides by LC-ESI-MS, CAD/MS and MS/MS with a Hybrid Tandem MS; *D’Agostino, PaulA.; Hancock,James R.; Provost,LionelR.; DefenceResearch Establishment Suffteld APCI LC/MS/MS Analysis of Bis (2etbylhexyl) Hydrogen Phosphite; *Dejarme,Lindy E.; Alexander,CarlA.; Slivon, LaurenceE.; BattelleMemorialInstitute The Use of LC/MS to Support Formulation Development for Physical Pharmacy Applications; *Fink, Saul;Thakur,Ajit; Slayback,John;Bristol-MyersSquibbPharmaceutical Research Institute,New Brunswick,NJ Quantitative analysis of a new class of explosive compounds by LC-MS/MS; l Garofolo,Fabio;**Longo,Antonio; Pagliuca,Angelo; Migliozzi, Vincenzo;Tallarico,Carlo;DeRubeis,Fabio;Stama,Angelo;AMI-Aeroporto Praticadi Mare DASRS-RASAI-00040Praticadi Mare(Rome)ITALY Analysis of Protein Digests Using a Nano HPLC Column Coupled to a Microelectrospray Source; *Hall, Steven;Maltby, David; Jarvis,S.;Hutton-McKenna,T.; Salzman,J.; Burlingame,Alma; MassSpectrometry Facility, Universityof California, SanFrancisco Rationalizing the Generation of Fruit Flavor: Analysis of Key Intermediates by ESI-LC-MS/MS; *Herderich,Markus; Roscher,Rene;Schneider, Claus;Schwab,Willi; Schreier,Peter;Lehrstuhlfllr Lebensmittelchemie, Universit!&Wthzburg, Wurzburg,Germany Effects of Ion Pairing Agents on Signal Intensities in Electrospray and APCI Mass Spectrometry; l Iyer, RajN.; **Giordani,AnneB.; Parke-Davis Pharm.1 Res.,Div. of Warner-Lambert Co.,Ann Arbor, MI On-Line Nanospray Analysis of Recombinant Proteins Digest by Pneumatic Spitter-LCMS; *Le, JohnC.; Haniu, Mitsuru; Hui, John;Katta,Vish; Rohde,Michael;ProteinStructure,AmgenInc., Thousand Oaks,California91320 On-line Microdialysis for Sample Clean-up in Electrospray Ionization Mass Spectrometry; *Liu, Chuanliang; Wu, Qinyuan;Smith,RichardD.; PacificNorthwestNationalLaboratory Analysis of Steroids by Electrospray LC/MS; *Ma, Yee-Chung;**Kim, Hee-Yong;Sectionof MassSpectrometry, LMBB, NIAAA, NIH Determination Of The Active Site For Peptidylglycine-alpha-Amidafing Monooxygenase by LC-EWMSIMS; *Marquez, CristinaD.; Treston,AnthonyM.; BPRB,NationalCancerInstitute,Rockville,MD 20850-3300 SFE and Atmospheric Pressure Chemical Ionization MS/MS Identification of Cepaenes; *Matusik,Jean;Block, Eric; White,Kevin; Calvey,Elizabeth;USFoodandDrugAdministration,CFSAN,Washington, DC 20204 The Characterization of Di- and Triglycerides in Oils and Fats by API LCIMS; *McIntyre, Doug;Fischer,Steven; Hewlett-Packard Company Method for Electrospraying Solutions Containing Non-Volatile Buffers using a High Flow Sheath Liquid; *Mylchreest, Iain; Sweeney,Matt; FinniganMAT, SanJoseCalifornia ES1 and APCI LClMS Application to Extractables from Drug Delivery Devices and Container Systems; *Norwood, DanielL.; Feinberg,ThomasN.; Mullis, James0.; MagellanLaboratories, Inc., Research TrianglePark,NC Corticosteroids determination by LC-MS ; application of a new ES1 source on a high resolution MS; **RizeaSavu, SimonaMarilena;*Silvestro,Luigi; Maurer,Karl Heinz;AMD IntectraGmbH,Harpstedt,Germany Matrix Related Modification of Ionization in Bioanalytical LC-API-MS/MS; *Thomas,Darren;Clarke,Steve;Hemsley, Martin; Hill, Howard;Noctor,Terry; ComingHazleton,Otley Road,Harrogate,North Yorkshire,HG3 IPY, UK Ionization mechanisms of carotenoids during APCI and electrospray LCIMS; vanBreemen, RichardB.; *Huang,ChaoRan;Tan, Yecheng;Schilling,Alexander;Universityof Illinoisat Chicago,Chicago,Illinois Applications of ESI-TOF to LC-MS and CE-MS Characterization of Biological Molecules; *Verentchikov,Anatoli; Hsieh,Frank;Gabeler,Steve;Martin, Stephen;Vestal,Marvin; PerSeptiveBiosystems, Inc., Framingham, MA DNA/RNA STRUCTURE & ADDUCTS
Abstracts are arranged alphabetically byfirst author MPM MPM MPM MPM MPM MPM MPM
and Identifacation of Platinium DNA Adducts by ESIMWMS; *Anderson,Lawrence;Andrew%Paul; **Cullen,Kevin; Kaup,Sahana;Strong,John;FoodandDrugAdinistration,Laurel,MD,USA Analysis of Modified Oligonucleotides by CGE-ES-MS; *Barry, JohnP.; Vouros,Paul;TheBarnettInstitute,Northeastern University,Boston,MA. Stable isotope labeled nucleoside and DNA standards for analysis of DNA and damaged DNA; Bi, Sheng;Quearry, Bonnie;Mekonnen,Belew;Naritsin,Dmitry; *Markey, SanfordP.;NationalInstituteof MentalHealth,Bethesda Detection and Characterization of DNA Adducts of DBC and MDBC via FAB and ES1 Mass Spectrometry; *Byun, Jaeman;Ramanathan, Ragman;Gross,Michael;Liang,Chen;Cavalieri,Ercole;Department of Chemistry,Washington University,St.Louis,MO 63130 Development of reversed-polarity CE/ESI/MS as a new screening tool for DNA adducts; *Chambers, David; Turteltaub, Kenneth;Mauthe,Robert;Andresen,Brian;LawrenceLivermoreNationalLaboratory Structural analysis of 2’-deoxynucleotide adducts with electrospray tandem mass spectrometry.; *Esmans, Eddy; Vanhoutte,Koen;Lemiere,Filip; VanDongen,Walter;Universityof Antwerp(RUCA), Antwerp Analysis of reaction between d(TTGGCCAA) and a Pt-complex by enzymatic degradation, ES1 and MALDI; *Gannet, Florence;Kocher,Florence;Blais,JeanClaude;Bolbach,G rard;+*Chottard,JeanClaude;Tabet,JeanClaude;Universit Pierreet Marie Curie,CNRSEP 103,Paris Charactization
394 .
44TH
ASMS
CONFERENCE
ON
MASS
SPECTROMETRY
* MPM MPM MPM MPM MPM MPM MPM MPM MPM MPM MPM MPM MPM MPM MPM MPM MPM
PAH-modifled DNA Adduct isomer distinction using Post Source Decay MALDI-TOF; *Gooden, Jonathon; Byun, Jaeman; Gross, Michael; Chen, Liang; Cavalieri, Ercole; Washington University, Chemistry Department, St. Louis, MO 63 130 Analysis of 1,Zepoxy3-butene Adducts of Cuanine in Calf Thymus DNA Using (LCIESI MS/MS); *Kambouris, S. J.; Chaudhary, A. K.; Selzer, R. R.; Oe, T.; Yeola, S. N.; Elfarra, A. A.; Blair, 1. A.; Vanderbilt University, Departments of Chemistry and Clinical Pharmacology Determination of DNA Adducts from Exposure to Tetranitromethane by CE/MS; l Keever, Jeffrey; Voyknser, Robert; Blake, James; Morgan, D.; Cunningham, Mike; Analytical & Chemical Sciences, Research Triangle Institute, RTP, NC 27709 In-source-CID Electrospray MS of Modified Oligonucleotides combined with CZE; *Linscheid, Michael; Siethoff, Christoph; ISAS Dortmund Derivatization and quantillcation of thymidine glycol or thymine glycol by GCIECNI-MS; +Naritsin, Dmitry; Bi, Sheng; Mekonnen, Belew; Quearry, Bonnie; Markey, Sanford P.; National Institute of Mental Health, Bethesda, MD A mass spectrometric investigation of the reaction between platinum(I1) ligand and d(CpGpTpApCpG); *Ni, Jinsong ; McCloskey , James; **Lowe, Gordon; Vilaivan, Tirayut; Department of Medicinal Chemistry, University of Utah, USA The effect of modified base or/and sugar to the oligonucleotide dissociation in the gas phase; *Ni, Jinsong; McCloskey , James; Davis, Darrel; Department of Medicinal Chemistry Analysis of Urinary Guanine-1,2,3&Diepoxybutane Adduct Using LC/ESI MS/MS; l Oe, Tomoyuki; Chaudhary, Ajai K.; Kambouris, Sara J.; Yeola, Suresh N.; Blair, Ian A.; Vanderbilt University School of Medicine Electrospray Ionization FT-ICR MS Analysis of Modified Oligonucleotides; l Pasa-Tolic, Ljiljana; Muddiman, David C.; Bruce, James E.; Smith, Richard D.; Pacific Northwest National Laboratory Quantitation and structure elucidation of in vitro and in vivo formed estrogen-DNA adducts; *Ramanathan, Ragulan; Byun, Jaeman; Gooden, Jonathon; Gross, Michael; Stack, Douglas; Cavalieri, Ercole; Washington University, Department of Chemistry, St. Louis, MO 63 130 High-energy collision-induced dissociation of homo-N-deoxynucleosides; *Rozenski, Jef; Hossain, Natizal; Herdewijn, Piet; Rega Institute for Medical Research, F.F.W., K.U.Leuven Determination of Adducts of Cisplatin in DNA using CZE/ESI-MS; Siethoff, Christoph; Pongraz, Britta; l Linscheid, Michael; ISAS Dortmund Characterization of Aldehydic Abasic Sites by Electrospray Ionization Mass Spectrometry; Torres, M. Cecilia ; Rieger, Robert A.; *Iden, Charles R.; Department of Pharmacology, University at Stony Brook, Stony Brook, NY Quantification of Butadiene-induced DNA Adducts in vitro and in viva using LC-MS/MS; *Tretyakova, Natalia; Hass, J. Ronald; Swenberg, James; University of North Carolina at Chapel Hill, Chapel Hill, NC Evaluation of detection limits for detecting DNA-adducts with API mass spectrometry.; *Vanhoutte, Koen; Lemitre, Filip; Joos, Pieter; Van Dongen, Walter; Esmans, Eddy; University of Antwerp (RUCA), Antwerp Sequence determination of bypass product of DNA photoadduct by ES1 source CAD, MS/MS, and MALDBPSD; *Wang, Zhen; Ramanathan, Ragulan; Gross, Michael; Taylor, John; Department of Chemistry, Washington University, St. Louis, MO, 63 I30 Characterization of Protein-DNA Repair Complexes by Electrospray Ionization Mass Spectrometry; Zharkov, Dmitry 0.; *Rieger, Robert A.; Iden, Charles R.; Department of Pharmacology, University at Stony Brook, Stony Brook, NY PROTEINS AND PEPTIDES
Abstracts are arranged alphabetically byfirst author MPN MPN MPN MPN MPN MPN MPN MPN MPN MPN MPN
Accurate Mass Assignments of Protein Digest Fragments; *Barbacci, Damon C.; Edmondson, Ricky D.; Russell, David H.; Texas A&M University, College Station Combining Rapid Proteolysis with Nano-electrospray Ionization for Protein Characterization; *Blackbum, Kevin; Anderegg, Robert; GlaxoWellcome, Inc., Research Triangle Park, NC C-Terminal Ladder Sequencing for Modified Peptides by Carboxypeptidase and MALDI-MS; *Chang, Yoon-Seok; Kim, Jin-Sung; Hanyang University, Ansan, Korea Peptide Fragment-Ion Tags from MALDUPSD for Error-tolerant Searching of Genomic Databases; *Clauser, Karl R.; Baker, Peter; Burlingame, Alma L.; Department of Pharmaceutical Chemistry, Univ. of California, San Francisco Automated characterization of proteins by liquid chromatography -tandem mass spectrometry; *Ducret, Axel; Eng, Jimmy; Yates, III, John; Aebersold, Ruedi; Dept of Molecular Biotechnology, University of Washington, Seattle WA 98195 Improvements in Mass Measurement Accuracy of MALDI-TOF; l Edmondson, Ricky D.; Russell, David H.; Texas A&M University, College Station An Interactive Environment on the World Wide Web for Protein Mass Spectrometry; l FenyO, David; Zhang, Wenzhu; Beavis, Ron C.; Chait, Brian T.; The Rockefeller University, New York, NY 10021 PepFrag - a SoBware Tool for Protein Identification Using MS/MS Information; *FenyO, David; Qin, Jun; Chait, Brian T.; The Rockefeller University Automated On-Line LClMS Methods for Protein Sample Cleanup and Characterization; *Hail, Mark E.; Nedved, Michael L.; Warrack, Bethanne M.; Thompson, William L.; Lee, Mike S.; Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ Peptide Sequencing by MALDI-TOF using Direct and Database Strategies; *Hines, Wade; Patterson, Dale; Takach, Ed; Vestal, Marvin; Martin, Stephen; PerSeptive Biosystems,Inc., Framingham MA Protein Ladder Sequencing Peptides Containing Lysine After Enzymatic Digestion Using MALDIfI’OF MS; Holland, Ricky D.; **Persons, Cecil; *Heinz, Thomas M.; Lay, Jr., Jackson 0.; National Center for Toxicological Reseach, Jefferson, AR, 72079
PRELIMINARY
MPN MPN MPN MPN MPN MPN MPN MPN MPN MPN MPN MPN MPN MPN MPN MPN MPN MPN MPN
MPN MPN
MPN
MPN MPN MPN MPN MPN MPN MPN
PROGRAM
395
Novel picomole scale derivatization of peptides with a tris(trimethoxyphenyI)phosphonium moiety; *Huang, Zhi-Heng; Wu, Jiang; Yang, Ying; Watson, J. Throck; Gage, Douglas A.; Department of Biochemistry, Michigan State University, East Lansing Ragged end peptides as probes for protein identification by mass spectrometry and database searches; *Jensen, Ole Njrregaard; Vorm, Ole; Mann, Matthias; European Molecular Biology Laboratory (EMBL), D-69012 Heidelberg, Germany Characterization of Errors in the Molecular Weight Measurement of Proteins by ESI; *Johnson, Kenneth L.; Tomlinson, Andy J.; Naylor, Stephen; Mayo Clinic, Rochester, MN 55905, USA Strategies for Protein Characterization: Membrane Preconcentration and Low Flow ESI; *Johnson, Kenneth L.; Tomlinson, Andy J.; Clarke, Nigel J.; Naylor, Stephen; Mayo Clinic, Rochester, MN 55905, USA Improved Peptide Analysis Using “ZoomScan” on an LC/MS/MS Ion Trap Mass Sectrometer; *Land, Adrian P.; Sanders, Mark; Schwartz Jae; Finnigan MAT, 355 River Oaks Parkway, San Jose, CA 95134 Direct Analysis of Crude Protein Mixtures by MALDI MS With the Aid of Polymeric Substrates; *Liang, Xiaoli; Bai, Jian; Cain, Teresa C.; Liu, Yan-Hui; Lubman, David M.; Department of Chemistry, The University of Michigan, Ann Arbor, MI 48109 MS Applied to Structural Investigations of Hydrogen Cyanide Polymers; l Minard, Robert; Matthews, Clifford; Hatcher, Patrick; Gourley, Chris; Penn State University On-line purification of proteins using a polymeric reversed phase gel with micro-ES/MS; l Nakanishi, Toyofumi; Shimizu, Akira; Caprioli, Richard; University of Texas Medical School, Houston, Texas 77030 Structural Identification of the N-terminal Neutral Losses from Protonated Peptides; *Nold, Michael ; Wesdemiotis, Chrys; Chemistry Department, The University of Akron, Akron Ohio 44325-3601 Identification of Proteins by MicroIonSpray Mass Spectrometry of Enzymatic Digests; l Nuwaysir, Lydia; McLean, Matthew; Bonner, Ron; Yarnane, Dave; Chen, Ling; PE Sciex, Applied Biosystems Division Identification of Mouse Liver Proteins on 2-D Gels by MALDI-MS of in situ Enzymatic Digests; *O’Connell, Kathy; Powell-Braxton, Lyn; Warburton, Cara; Stults, John; Genentech, Inc., South San Francisco, CA 94080 The use of n-butyl esters to improve the ESI-MS and ESI-MS/MS analysis of peptides and amino acids; *Papayannopoulos, Ioannis A.; Biogen Inc., Cambridge, MA High Confidence Identification of Gel-Separated Proteins; *Qin, Jun; Fenyo, David; Zhao, Yingming; Chait, Brian; The Rockefeller University, 1230 York Ave., New York, NY 10021 Copper Stain Provides an Effective Interface between Gel Electrophoresis and Mass Spectrometry; Qin, Jun; Wang, Yi; *Chait, Brian; The Rockefeller University, 1230 York Ave., New York, NY 10021 Mass Spectrometry as a Tool in Systematic Peptide Sequencing; *Raida, Manfred; Heine, Gabi; Schulz-Knappe, Peter; Forssmann, Wolf-Georg; Niedersaechsisches Institut fuer Peptid-Forschung, Harmover, Germany Mass Spectrometric Analysis of Peptide Mixtures, Comparison of LC-MS and MALDI-MS; *Raida, Manfred; Schrader, Michael; Neitz, Susanne; Forssmann, Wolf-Georg; Niedersaechsisches Institut fuer Peptid-Forschung, Harmover, Germany The Effect of Delayed Extraction on the MALDI-PSD and MALDI-PSD-CID Mass Spectra of Peptides; *Roberts, Gerald D.; Carr, Steven A. ; Hemling, Mark E.; Critchley, Glenn (2); **Brown, Jeff (2); Hoyes, John (2); SmithKline Beecham Pharmaceuticals, King of Prussis, PA 19406 Application of MALDI-FTMS to Protein 6Ladder6 Sequencing; *Scott, Jill R.; SchYrch, Stefan; Moore, Sean; Wilkins, Charles L.; University of California, Riverside Large Scale Identification of Yeast Proteins Exclusively by Mass Spectrometric Methods; l Shevchenko, Andrej; Wilm, Matthias; Jensen, Ole; Vorm, Ole; Shevchenko, Anna; Sagliocco, Francois; Boucherie, Helain; Mann, Matthias; European Molecular Biology Laboratory (EMBL) Sample Preparation Techniques for Femtomole Sequencing of Proteins from Polyacrylamide Gels; *Shevchenko, Andrej; Jensen, Ole; Wilm, Matthias; Mann, Matthias; European Molecular Biology Laboratory (EMBL) Directing Fragmentation for Primary Structure Elucidation of Peptides by Postsource Decay MALDI; *Spengler, Bernhard; Luetzenkirchen, Frank; Metzger, Sabine; Kaufmann, Raimund; Jeffery, William; Pappin, Darryl J. C.; Inst. of Laser Medicine, Univ. of Duesseldorf, Germany MALDI Mass Measurement Accuracy of Proteins Directly from Polyacrylamide Gels and Membranes; *Stevenson, Tracy I.; **Ogorzalek Loo, Rachel R.; Mitchell, Charles; Loo, Joseph A.; Andrews, Philip C.; Parke-Davis Pharmaceutical Research, Ann Arbor, MI Fragmentation properties of protonated peptides with both acidic and basic amino acid residues; *Summerfield, Scott G.; **Kingston, Robert; Gaskell, Simon J.; Michael Barber Centre for Mass Spectrometry, UMIST, Manchester, U.K. The Analysis of Myocardial Proteins by Infrared and Ultraviolet Laser Desorption Mass Spectrometry.; *Sutton, C. W.; U., S.; Evans, S.; Corbett, J. M.; Wheeler, C. H.; **Dunn, M. J.; Therm0 BioAnalysis Ltd., Hemel Hempstead, UK Positive Identification of Proteins by Peptide Maps with High Mass Accuracy and Sequence Coverage; l Vorm, Ole; Jensen, Ole N.; Mann, Matthias; Dept. of Chemistry, Odense University, Denmark Protein Characterization at the Picomole level with Coupled Capillary LC/MS Systems; *Wang, Hongqi; Jindal, Satish; Carson, Bill; Martin, Stephen; Regnier, Fred; PerSeptive Biosystems, Framingham, MA Carboxyl-terminal ladder sequencing of peptides for protein identification; *Wang, Rong; Sechi, Salvatore; Chait, Brian; The Rockefeller University A Novel Strategy for Assignment of Disulfide Bond Pairing in Proteins; *Watson, J.T.; Wu, Jiang; Dept. of Chemistry, Michigan State University, East Lansing, MI 48824 Deconvolution of Natural Isotopic Abundance Patterns by Least Squares and Maximum Entropy Methods; *Zhang, Zhongqi; Guan, Shenheng ; Marshall, Alan G.; National High Magnetic Field Lab, Florida State Univ., Tallahassee, FL
396
.
* MPN
44TH
ASMS
CONFERENCE
ON
MASS
SPECTROMETRY
Charrcterixation of an Unstable Intermediate Formed During Cyrnogenbromide Cleavage of a-endorphin; Zhang, Xinyi; Dillen, Lieve; l Claeys, Magda; Van Dongen, Walter; Vanhoutte, Koen; Esmans, Eddy; University of Antwerp (UIA and RUCA)
TUESDAY ION-MOLECULE
POSTERS
REACTIONS
Abstracti ore arranged alphabetically byf7rst author TPA TPA TPA TPA TPA TPA TPA TPA TPA TPA TPA TPA TPA TPA TPA TPA TPA TPA TPA TPA TPA TPA TPA TPA TPA TPA TPA TPA
Ion-Molecule Reaction Kinetics at Your Fingertips.; *Anicich, Vincent; Jet Propulsion Laboratory A Collision Cell with Electrostatic Ion Guide for Collision Cross Section Study of Protein Ions; *Bondarenko, Pavel; Macfarlane, Ronald; Department of Chemistry, Texas A&M University, College Station, TX 77843 Dimethyl ether CI mass spectrometry of isomeric methylated nucleic acid bases and nucleosides; *Burrows, E. P.; USACHPPM Research Detachment, Fort Detick, Frederick, MD Gas-Phase Basic@ Determinations of High Basic@ Amino Acids and Small Peptides; *Carr, Scott R.; Cassady, Carolyn J.; Miami University, Oxford, Ohio The Unexpected Reactivity of Phenylium Ions; *Chou, P. K.; Nousiainen, J.; Perez, J.; Kenttamaa, H. I.; Department of Chemistry, Purdue University Reactions of Ar+ ions with CO2 and SO2 at high temperatures.; *Dotan, Itzhak; Viggiano, ALA, Phillips Laboratory, GPID, Hanscom AFB, MA 01731-3010, U.S.A A PM0 theory of gas-phase proton-transfer rates; *Dougherty, Ralph; Dept of Chemistry, Florida State University, Tallahassee FL 32306-3006 Intermediates in Sulphur-rich Flames - On the Identity of the C2H3S+ Chemi-ion; *Egsgaard, Helge; Carlsen, Lam; Sorrilha, Ana Elisa P. M.; Eberlin, Marcos N.; Risi National Laboratory, DK-4000 Roskilde, Denmark Toluene CI vs Methane/Ammonia CI for the Anaylsis of Methyl Esters; *Evans, Jason; Munson, Bumaby; Nicol, Gordon; University of Delaware Gas-Phase Basicities of Small Peptides of Proline and Glycine: The Enhanced Basic@ of ProPro; *Ewing, Nigel; Zhang, Xin; Cassady, Carolyn; Miami University, Oxford The CH30He I II20 AND C2H50H+Y I H20 systems : a M.O. approach; Fossey, Jacques; Dahhani , Fadil; l Audier, Henri; DCMR, CNRS URA 1307, Ecole Polytechnique, F-9 1128 PALAISEAU 2,3-Dihydrofuran and 2,5-Dihydrofuran Radical Cations; *Gao, Lan; Nousiainen, Jaakko; Kenttarnaa, Hilkka; Department of Chemistry, Purdue University, West Lafayette Gas phase reactions of silicon and boron hydride cations in the FA-SIFT; *Gareyev, Roustarn; Damrauer, Robert; DePuy, Charles H.; Department of Chemistry and Biochemistry, University of Colorado at Boulder Mechanisms of water losses from cis and trans indanediol adduct ions in dimethylether CI; Gervat, Vincent; Foumier, Francoise; Perlat, Marie-Claude; *Tabet, Jean-Claude; Universite Pierre et Marie Curie (PARIS) The Role of Proton-Bridged Intermediates in Gas-Phase H-D Exchange Reactions; *Green, M. Kirk; Lebrilla, Carlito B.; University of California, Davis Structure Determination in a Series of Substituted Silacyclobutane Ions Using Triple Quadrupole MS; *Hankin, Joseph A.; **Damrauer, Robert; University of Colorado at Boulder; Boulder, CO 80309 Tandem Mass Spectrometry of Gas Phase Protonated Organophosphorus Compounds; l Hesso, Antti; Tomaeus, Jarkko; l *Bjoerk, Heikki; Finnish Institute of Occupational Health, Helsinki, Finland Distonic Ions of the “ate” Class; *Hill, Brian T.; Chyah, Leonard J.; Poutsma, John C.; Hu, Jun; Squires, Robert R.; Purdue University, Department of Chemistry, West Lafayette, IN 47907 Synthesis and Characterization of Distonic Biradical Ions; *Hu, Jun; Squires, Robert R.; Purdue University, Department of Chemistry, West Lafayette, IN 47907 Unexpected addition reactions observed in isobutane CI in new generation ITD.; *Jalonen, Jorma; Joensuu, PBivi; Department of Chemistry, Univ. of Oulu, POB 333, FIN-90571 Oulu, Finland Reactivity of the epimeric 3, Cchromanediols towards the NH3/NH4+ system; Kang, Yoon-Joo; Meyer, Michtle; Dana, Gilbert; *Foumier, Francoise; Tabet, Jean-Claude; Universite Pierre et Marie Curie (Paris) The Bronsted Acidity of Simple Aldehyde and Ketone Radical Cations; Kenttamaa, Hilkka I.; *Byrd, H.C. Michelle; Department of Chemistry, Purdue University, West Lafayette HydrogenlDeuterium Exchange in the Reactions of Methyl Cation with Methane; *Lee, Hack Sung; Bierbaum, Veronica M.; DePuy, Charles H.; Department of Chemistry, University of Colorado at Boulder Reactions of chloroorganics with oxygen in the collision cell of a triple quadrupole.; *Lepine, Francois; Boismenu, Daniel; Mamer , Orval; Institut Armand-Frappier, Laval, Quebec, Canada Fluorine Substitution Enhances the Reactivity of Charged Phenyl Radicals Toward Hydrogen Atom Donors; l Li, Ruomei; Smith, Rebecca L.; Kenttamaa, Hilkka I.; Purdue University, West Lafayette, IN 47907-1393 Gas Phase Reactions of Metal Ions of Interstellar Interest; *Linder, Christopher; Babcock, Lucia; University of Georgia, Athens, Georgia, 30602 A Gas-Phase Structurally Diagnostic Ion-Molecule Reaction for l&0,0and 1,3-O,!I-Heterocycles.; Moraes, Luis Alberta B.; Gozzo, Fabio C.; Eberlin, M. N.; **Vainiotalo, Pirjo; State University of Campinas, Institute of Chemistry, Campinas, Brasil. Neutral Products from Rearrangements of 2-Hydroxyethyl Cations Produced by Tritium Decay; *Morton, Thomas Hellman; Bennett, Jacqueline S.; University of California, Riverside
PRELIMINARY
TPA TPA TPA TPA TPA TPA TPA TPA TPA TPA TPA TPA TPA TPA
PROGRAM
397
Cation Attachment to Multiply-Charged Anions of Bovine Insulin A-chain; McLuckey, Scott A.; *Goeringer, Douglas E.; Herron, William J.; Stephenson, James L.; Oak Ridge National Laboratory Gas-Phase Reactivity of Simple Ionized Carbenes ; *Nelson, Eric D.; Thoen, Kami K.; Kenttamaa, Hilkka I.; Purdue University, West Lafayette, IN The Structure of Protonated Aniline in the Gas Phase; *Nold, Michael ; Wesdemiotis, Chrys; Chemistry Department, The University of Akron, Akron Ohio 44325-3601 EI and CI Mass Spectra of Some Oligomeric Polyethylene Glycols and Ethers; *Onigbinde, Adebayo; Nicol, Gordon; Munson, Bumaby; University Of Delaware, Newark DE 19716 Gas-Phase Negative Ion Chemistry of Lewis Acid-Base Complexes; *Ren, Jianhua; Workman, Derek B.; Squires, Robert R.; Purdue University, Department of Chemistry, West Lafayette, IN 47907 H-atom and N-atom reactions with Molecular Ions.; Scott, Graham; Fairley, David; Freeman, Colin; *McEwan, Murray; University of Canterbury, Christchurch, New Zealand. High Pressure Electron Capture Responses and Spectra of Substituted Nitrobenxenes; *Sears, L.J.; Knighton, W.B.; Grimsrud, E.P.; Montana State University Bozeman, MT The Detection and Study of Electronically Excited Species in the CI Source; *Stemmler, Elizabeth; Wert, Bryan; Bowdoin College, Brunswick Probing Substituent Effects on the Reactivity of Charged Phenyl Radicals; l Thoen, Kami K.; Stumpf, Chris L.; Kenttamaa, Hilkka I.; Purdue University, West Lafayette, IN Distinction between propenyl and ally1 cations: WD exchange with D20.; van der Rest, Guillaume; *Mourgues, Philippe; Audier, Henri Edouard; Ecole Polytechnique DCMR - URA CNRS 1307 Oxygen Exchange in the Formaldehyd-Water Proton Bound Dimer; van der Rest, Guillaume; Fossey, Jacques; Mourgues, Philippe; *Audier, Henri-Edouard; Laboratoire des M canismes R actionnels - UR4 CNRS 1307 Palaiseau Reactions of Simple Ions and Water/Acetonitrile Ion Clusters with Acetonitrile Molecules; *Vinogradov, P. S.; Borisenko, D. M.; Veretennikov, I. N.; Institute of Energy Problems of Chemical Physics, Russian Academy of Sci. Generation of neutral silaethenes by neutralization-reionization mass spectrometry; *Zagorevskii, Dmitri; Dakubu, M.; Holmes, John L.; Chemistry Department, University of Ottawa, Ottawa, Ontario, Canada KIN 6N5 Determination of Gas Phase Basicities of Multiply Protonated Peptide Ions by FT-MS; *Zhang, Xin; Cassady, Carolyn; Miami Univeristy, Oxford, Ohio
ION ACTIVATION AND DISSOCIATION Abstracts are arranged alphabetically byfirst author TPB TPB TPB TPB TPB TPB TPB TPB TPB TPB TPB TPB TPB TPB TPB TPB TPB
Background Reduction In Photodissociation Spectra by Improved Sample Preparation; *Barbacci, Damon C.; Edmondson, Ricky D.; Russell, David H.; Texas A&M University, College Station Carbohydrate Analysis Using ElectrospraylPhotodissociation in the Quadrupole Ion Trap; *Boue, Stephen M.; Stephenson , James L. (2); Yost, R.A. (I); University of Florida Infrared Multiphoton Photodissociation in a Quadrupole Ion Trap Mass Spectrometer; *Colorado, Armando; Brodbelt, Jennifer; University of Texas, Austin, TX Comparison between SID and Thermal Decomposition Kinetics of Non-Specific Dimers; *Dongre, Ashok; Somogyi, At-pad; Nair , Hari; Meot-Ner, Michael; Wysocki, Vicki; Virginia Commonwealth University Systematic Studies to Test the Validity of the Mobile Proton Model for Fragmentation of Peptides; l Dongre, Ashok; Somogyi, Arpad; Jones, Jennifer; Wysocki, Vicki; Virginia Commonwealth University Steps on the Road to Interpretation of Photo-Induced Dissociation Spectra; *Erickson, Tina; Beussman, Douglas; Constantopoulos, Terri; Enke, Chris; University ofNew Mexico, Albuquerque Enrichment and Characterization of the Noble Gas Fullerene Ar(iiJC60; *Hettich, Robert; DiCamillo, Barbara; Compton, Robert; Guiochon, Georges; Oak Ridge National Laboratory Probing reactions occurring during surface induced dissociation(SID) tandem mass spectrometry(ms/ms); *Manzella, Lynn; **Hayward, Mark; Bemasek, Steven; Department of Chemistty- Princeton University-Princeton, NJ Photodissociation of Dye Molecular Ions in an RF Ion Trap: l Michisato, Toyoda; Masahiro, Kimura; Takekiyo, Matsuo; Dept. of Physics, Fat. of Science, Osaka University Soft-landing of polyatomic ions at fluorinated self-assembled monolayers; *Miller, Scott; Luo, Hai; Cooks, R. G.; **Pachuta, Steven; Purdue University Microchannel plate surface-induced reactions at the entrance of a RF-only quadrupole.; *Mougef Yves; Bertrand, Michel J.; University of Montreal, Montreal. Effect of N-alkylation of Amide Bond on Its Cleavage by SID; Demonstration of the Proline Effect; *Nair, Hark Somogyi, Arpad; Wysocki, Vicki; Virginia Commonwealth University “The mobile proton model of peptide fragmentation: comparison of SID and CID data”; *Nair, Hari; Wysocki, Vicki; Summerfield, Scott; Gaskell, Simon; Virginia Commonwealth University, Richmond Blackbody Infrared Dissociation: Binding Energies of Non-Covalent Biomolecule Complexes in Vacua; *Schnier, Paul; Price, William; Williams, Evan; University of Califomiq Berkeley Addition of H, F, and CH3 to Small Organic Projectiles in Low Energy Ion-Surface Reactions; l Somogyi, Arpad; Shillady, Donald; Wysocki, Vicki; Virginia Commonwealth University Activation Energy of Fragmentation of Protonated Peptides Determined by a New Approach; l Vekey, Karoly; **Somogyi, Arpad; Wysocki, Vicki; Nair, Hari; Central Research Institute for Chemistry of the Hungarian Acad. of Sciences Analysis of Fragment Ion Kinetic Energy Distributions During Surface-Induced Dissociation; *Wainbaus, Samuel B.; Lim, Hanjo; Schultz, David; Hartley, Luke; University of Illinois at Chicago
398 .
4-4TH
ASMS
CONFERENCE
ON
MASS
SPECTROMETRY
. TPB
Thermochemical Measurements with Surface-induced Hartley, Luke; University of Illinois at Chicago TRAPPED IONS
Dissociation;
* Wainhaus, Samuel B.; Schultz, David; Lim, Hanjo;
Abstracts ore arranged olphobeticolly byfirsr author TPC TPC TPC TPC TPC TPC TPC TPC TPC TPC TPC TPC TPC TPC TPC TPC TPC TPC TPC TPC TPC TPC TPC TPC
TPC TPC TPC TPC TPC
Characterization of MALDDFTICR Performance With an Inhomogeneous Superconducting Magnet; *Anderson, J.S.; Laude, D.A.; The University of Texas at Austin Techniques for Uncoupling Coalescing Isotopic Distributions in MALDDFTICR; *Anderson, J.S.; Laude, D.A.; The University of Texas at Austin FTICR Ion Remeasurement Techniques for Small Molecules; l Blakney, G.T.; Karpinski, M.L.; Laude, D.A.; The University of Texas at Austin Magnetic Field Focusing Electrospray FTICR on a High Field Magnet; Drader, J.J.; Hendrickson, C.L.; Robinson, J.M.; *Laude, D.A.; Dept. of Chemistry and Biochemistry, The University of Texas at Austin High Resolution, High Mass Accuracy, and Performance with an Internal MALDI ICR; +Easterling, Michael; Pitsenberger, Cynthia; Kulkarni, Shubhada; Taylor, Kristi; Amster, 1. Jonathan; University of Georgia MALDI FT-ICR MS Analysis of Luteinizing Hormone Releasing Hormone at Biological Concentrations; *Emmett, Mark R.; Solouki, Touradj; Marshall, Alan G.; National High Magnetic Field Lab, Florida State Univ., Tallahassee, FL Characterization of a Multi Electrode Ion Trap; *Engelmohr, Peter; Wanczek, Karl Peter; Inst. of Inorg. and Phys. Chemistry, University of Bremen, D-28344 Bremen Modeling of Ion Injection and Trapping for a Versatile External Source FTMS System; *Futrell, Jean; Nikolaev, Eugene; Rakov, Sergey; **Becker, Bruce; Winger, Brian; Campana, Joe; University of Delaware, Newark, DE Hadamard Transform FIICRMS of Multiply-charged Protein Ions; l Gao, Xuling; Wood, Troy; State University of New York at Buffalo Theoretical description of a Wire Ion Guide (WIG) cell; Gillig, Kent, . *BIuhm, Brian; Russell, David; Texas A&M University College Station Dependence of FT-ICR Time-Domain Signal Decay Envelope on Ion-Neutral Collision Mechanism; *Guan, Shenheng; Li, Guo-Zhong; Marshall, Alan. G.; National High Magnetic Field Lab, Florida State Univ., Tallahassee, FL Internal Energy Deposition by Quadrupolar Excitation in the Presence of Collisional Cooling; l Guan, Shenheng; Xin, Tianpei; Reinhold, Bruce B.; Marshall, Alan G.; National High Magnetic Field Lab, Florida State Univ., Tallahassee, FL On-Line, Capillary HPLC Interface for a Magnetic Field Focusing ESYFTICR; *Harper, C. J.; Bolanos, B. J.; Arkin, C. R.; Torres, T. A.; Schmidt, E. G.; Laude, D. A.; The University of Texas at Austin MALDI FT-ICR Mass Spectrometry in a 20 Tesla Resistive Magnet; *Hendrickson, Christopher L.; Guan, Shenheng; Marshall, Alan G.; National High Magnetic Field Lab, Florida State Univ., Tallahassee, FL Scaling Factors for Excitation Potentials in Tetragonal and Cylindrical Penning Traps; *Jackson, George S.; Guan, Shenheng; Marshall, Alan G.; National High Magnetic Field Lab, Florida State Univ., Tallahassee, FL Selective Broadband Quadrupolar Axialization in FTICR; *Karpinski, M.L.; Blakney, G.T.; Bolanos, B.J.; Laude, D.A.; The University of Texas at Austin A Small Permanent Magnet FT-ICR Spectrometer; *Kofel, Peter; Institute of Organic Chemistry, University of Bern, CH3012 Bern Characterization of Open ICR Cells with Trajectory Calculation; *Kuhnen, Florian; Wanczerk, Karl Peter; Inst. of Inorg. and Phys. Chemistry, University of Bremen, D-28334 Bremen *Kulkarni, Shubadha; Taylor, Kristi; Amster, Nanoelectrospray Ionization FTICR Spectrometry of Metalloproteins; Jonathan; Department of Chemistry, University of Georgia, Athens, GA 30602-2556 Distribution and Density of Trapped Ions; *Li, Guo-Zhong; Guan, Shenheng; Marshall, Alan G.; National High Magnetic Field Laboratory, Florida State Univ., Tallahassee Assessment of ion-trapping efficiency in FIMS-SORI by computer simulation of ion trajectories; **Naito, Yasuhide; *moue, Masao; Univ. of Electra-Communications, Tokyo, Japan Determination of excitation frequency for fixed-frequency pulse excitation waveform in FT-ICRIMS; *Naito, Yasuhide; moue, Masao; Univ. of Electra-Communications, Tokyo, Japan Capabilities of Broadband Quadrupolar Axialization Over a Wide Mass Range; *Pitsenberger, Cynthia C.; Easterling, Michael L.; Amster, I. Jonathan; The University of Georgia Compensation and RF-Only Mode for Improved Detection of High Mass in a Superconducting Solenoid FTMS; *Rempel, D. L.; Holliman, C. L.; Jacoby, C. B.; Ramanathan, R.; Gross, M. L.; Department of Chemistry, Washington University, St. Louis, MO 63 130-4899 Approaches to Ion Mobility Measurements in an FTICR Spectrometer; *Schmidt, E.G.; Laude, D.A.; The University of Texas at Austin Electronspray Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometry at 9.4T; *Senko. Michael W.; Hendrickson, Christopher L.; White, Forest M.; Quinn, John P.; Marto, Jarrod A.; Pass-Tolic, Ljiljana; Guan, Shenheng; Marshall, Alan G.; National High Magnetic Field Lab, Florida State Univ., Tallahassee, FL Ion Storage Mass Spectrometry for Sequencing MHC Class-II Peptides; *Settlage, R.E.; Marto, J.A.; Yates, N.A.; Shabanowitz, J.; Hunt, D.F.; University of Virginia Semiconductor Gas Purity and Process Characterization by FI’-ICR; *Smith, Derek; Brooks, Larry; Hoffman, John; **Hogan, Jerry; Chorush, Russell; University of Texas at Dallas Richardson Charge State of Substituted Sulfurhexafluorides; Spie8, Iris; Kuhnen, Florian; * Wanczek, Karl Peter; Inst. of Inorg. and Phys. Chemistry, University of Bremen, D-28334 Bremen
PRELIMINARY
TPC TPC TPC
PROGRAM
399
Distinction of Coulombic and Conformstionsl Effects on Dissociation of Electrosprsyed Proteins; *Stevenson, E.; Bolanos, B. J.; Campbell, V. L.; Arkin, C. R.; Laude, D. A.; The University of Texas at Austin Optimization of an Ion-Ion Pulse Sequence for Negative ES1 Ions in a Five-Electrode Trapped-Ion Cell; *Torres, T.A.; Stevenson, E.; Harper, C.J.; Laude, D.A.; The University of Texas at Austin A Systematic Approach to Improve Mass Accuracy in FTICR Mass Spectrometry at Zero Trapping Potential; *Watson, Clifford H.; Goodner, Kevin L.; Eyler, John R.; Department of Chemistry, University of Florida, Gainesville, FL 3261 I-7200 ENVIRONMENTAL ANALYSIS
Abstracts are arranged aIphabetically byfirst author TPD TPD TPD TPD TPD TPD TPD
TPD TPD TPD TPD TPD TPD TPD TPD TPD TPD TPD TPD TPD TPD TPD TPD
TPD TPD TPD TPD
Laser Desorption Ionization TOF Mass Spectrometric Analysis of Chromium Containing Particulates; *Allen, Todd M.; Bezabeh, Dawit Z.; Jones, A. Daniel; Kennedy, Ian M.; Kelly, Peter B.; University of Califon&, Davis Comparative Evalutaion of the TCLP Zero-Headspace and Bottle Extractions Procedures; *Beihoffer, Jon; Seidel, Jimmy; Terry, Corey; U.S. EPA National Enforcement Investigations Center, Denver. CO Assessment of VOC Emissions from Chlorinated Drinking Water in Showers; *Benoit, Frank, **Mori, Brian; Alleyne, Carl; Health Canada, Environmental Health Directorate, Ottawa ON Canada Electron Energy-Dependent Regioselective Loss of Chloride Anions from Polychlorodibenzo-p-dioxins; *Berkouf Vadym; Laramee, James; Deinzer, Max; Dept. of Agricultural Chemistry, Oregon State University, Corvallis, OR Evolving Criteria for Mass Spectral Confirmation at Trace Levels; *Cairns, Thomas; Psychemedics Corporation, Culver City, CA 90230 MALDI-TOF of Low Molecular Weight Organic Acids; *Campbell, James A.; Goheen, Steve C.; Wahl, Karen L.; Hess, Wayne P.; Pacific Northwest National Laboratory A Study of the Fuel/Air Ratio on Polymer Combustion Emissions by CC/MS; *Carlson, Joel; Dunayevskiy, Yuriy; Vouros, Paul; Atal, Ajay; Panagiotou, Thomai; Levendis, Yiannis; Dept. of Chem., Northeastern Univ., 360 Huntington Ave, Boston, MA, 02 I I5 Statistical Methods for Determining Detection and Quantitation Limits; *Coleman, David; Bethem, Robert; Alcoa Laboratories, Alcoa Center, PA A transportable isotopic dilution CC-MS system for atmospheric monitoring while driving in trafftc; *Davoli, Enrico; Cappellini, Luigi; Moggi, Marco; Ferrari, Stefano; Fanelli, Roberto; Istituto di Ricerche Farmacologiche Mario Negri Direct Capillary Column Desorption for CC/MS Analysis at High Helium Flow Rate; +Dejarrne, Lindy E,; Ray, Prasenjit; Slivon, Laurence E.; Battelle Memorial Institute A Field Portable Aerosol-Time-of-Flight Mass Spectrometer; *Dienes, Tas; Fergenson, David; Gard, Eric; Morrical, Brad; Prather, Kimberly A.; University of California, Riverside Ultra Trace Analysis of Atmospheric Halocarbons using High Resolution Mass Spectrometry; l Engen, M.A.; Grimsrud, E.P.; Montana State University Bozeman, MT Rapid Analysis of TO-14 Airborne Contaminants By Fast GC/TOFMS; *Gardner, Ben; Holland, John; l *Berkley, Richard; Michigan State University Modeling Pyrolysis of PVC using FT-ICR; *Glaser, Brian S.; Haworth, James E.; Philips, Eugene; Hanson, Curtiss D.; University of Northern Iowa, Department of Chemistry, Cedar Falls, IA Applications of Mass Peak Profiling from Selected Ion Recording Data using Probe Introduction; *Grange, Andrew H.; **Brumley, William C.; Lockheed Environmental Systems and Technologies Company Static SIMS Investigation of Phosphaxene Polymers used for Contaminant Adsorption; *Groenewold, Gary; Cowan, Rob; Ingram, Jani; Appelhans, Anthony; Delmore, Jim; Idaho National Engineering Laboratory, Idaho Falls, ID Monitoring Volatile Organic Compounds in Gaseous Process Streams; *Hart, Kevin J.; Dindal, Amy B.; Smith, Rob R.; Oak Ridge National Laboratory Mechanisms of High Energy Combustion Reactions of Polyisoprene Pyrolysis; *Haworth, James E.; Glaser, Brian S.; Phillips, Eugene; Hanson, Curtiss D.; University of Northern Iowa, Cedar Falls, la CC/MS Determination of Metsulfuron methyl and Chlorsulfuron in Natural Waters - Matrix Effects; *Headley, John; **MacDonald, Linda; Peru, Kerry; National Hydrology Research Institute, Saskatoon Analysis of haloacetic acids in drinking water by supercritical fluid extractionlmethylation; *Her, G.R.; Sheen, J.F.; Department of Chemistry, National Taiwan University, Taipei, Taiwan, R.O.C. Identification of Photodegradation Products of DDT and Its Metabolites in Water; *Hong, Jongki; Yoo, Jong-Shin; So, Hun-Young; **Jung, Seong-Young; Kim, Kang-Jin; Korea Basic Science Institute, 224-1, Eoun-dong, Yusong-ku, Tajeon, Korea GC-MS Confirmation Analysis of a Low Volatility Organophosphorus Toxic Agent in Air Samples; *Jakubowski, Edward; Deel, Gail; SciTech Services Inc., Abingdon, MD 21009 Tandem and High Resolution Mass Spectrometry with FAB Ionization Analysis of Quat Pesticides; Josep, Caixach (I); Xavier, Huguet (I); Jesus, Cabanas (I); *Josep, Rivera (I); Maria Teresa, Galceran (2); Manuel Castro, Cameiro (2); Laboratori d’Espectrometria de Masses, CID-CSIC, Barcelona (SPAM) Analysis of Ethylenediaminetetraacetic Acid (EDTA) by Laser Desorption Ion Trap Mass Spectrometry; Komienko, Oleg; Brynjelsen, Sean; *Hanley, Luke; Orlando, Thomas M. (PNL); University of Illinois at Chicago Chlorination of Nitrogen-Containing Fragments of Humic Material; l Lebedev, Albert; Moshkarina, Natalia; But-yak, Alexei; Moscow State University Sample preparation for a mobile CC-MS-System; Matz, Gerhard; *Schillings, Alfred; Harder, Alexander; Technical University Hamburg-Harburg Differentiation of PAH Structural Isomers by Ion Molecule Reactions with Halogenated Reagent Gases; *Mosi, Andrew; Cullen, William; Eigendorf, Guenter; University of British Columbia, Department of Chemistry
400 .
* TPD
44TH
Ambient
Particle Classification
Capabilities
of Aerosol Time-of-Flight
ASMS
CONFERENCE
ON
Mass Spectrometry;
MASS
SPECTROMETRY
*Noble,Christopher; Prather,
Kimberly; Universityof California TPD
OnSite
Analytik Strategies for Mobile GC/MS Analysis; *N&Ike,Birgit; Zey, Thomas;Franzen,Jochen;Bruker-Franzen
GmbH.Bremen,Germany TPD
Dechlorination
Mechanisms
of Selected PCB Isomers Containing
Isotopicnlly
Enriched
Chlorine
Labels; *O’Brien,
RobertT.; Guevremont,Roger;Siu.K.W.M.; ChemicalMetrology, INMS, NRC.Ottawa TPD TPD
Comparison Of PAH Emission Of Standard Diesel, Biodiesel Fuels And Their Blends On Diesel Engine; *Pan,Joseph; **Haines,Howard;Southwest Research Institute,SanAntonio,Texas Merritt, Patrick;Mclntire, Tom; Sharp,Christopher; 78238 Direct Sampling MS and MS/MS for Real-Time Air Monitoring; +Remigi,Carla;Palmer,Pete;**Karr, Dane;San
FranciscoStateUniversity,SanFrancisco TPD
Low-Voltage
Sensitivities for Molecular
Ion Type Analysis of Fossil-Fuel Distillates;
l Scheppele, Stuart;Miller, James;
Research Resources Center,Universityof IlinoisChicago,Chicago,IL TPD
A Solid Scintillation
Cell For On-line Metabolite
Characterization
By Microcolumn
LC-RAM-MS;
*Schultz,GaryA.;
Alexander,James N.; RohmandHaasCompany,SpringHouse,PA 19477 TPD TPD TPD TPD TPD TPD TPD
Samples by Direct Laser Desorption Time-of-Flight MS; Soloveytchik, Boriana;**Dreifuss,PeterA.; *Vertes,Akos;GeorgeWashington University,Department of Chemistry GCMS Analysis of Air Samples and Metal Working Fluids from an Engine Plant; *Subramanian, Periyasamy;Thome, Peter;DeKoster,Jeannine; TheEnvironmental HealthSciences Research Center, Universityof Iowa Analysis of Geosmin and 2-Methylisoborneol by Isotope Dilution High Resolution Mass Spectrometry; *Taguchi,Vince; Jenkins,Steve;Wang,Dave;Palmentier, J-P.;Robinson, Don;OntarioMinistry of EnvironmentandEnergy,Mass SpectromettyLaboratory Method Development For Quantifying Chlorinated n-Paraffins by HRGC-ECNIHRMS.; *Tomy, Gregg;Stem,Gary; Muir, Derek;Westmore,John;Fisk,Aaron;Cymbalisty,Chris;Department of Chemistry,Universityof Manitoba,Winnipeg, Analyses of Airborne Species with a Field-Portable Large-Volume Air Sampler Mass Spectrometer; *Wahl, JonH.; Zemanian,ThomasS.;Robins,WilliamH.; Wright, BobW.; PacificNorthwestNationalLaboratory,RichlandWA Comparison of Scanning CCD Array and Point Detection for Small Molecule Analysis; *Wahl, K. L.; Campbell,J. A.; **Finch, J. W.; Miki, S.; PacificNorthwestNationalLaboratory Analysis of PM10 atmospheric particulate5 by laser desorption FTIICRIMS; *Xu, Ming; White,Forest;Marshall,Alan; Guan,Shenheng; Dougherty,Ralph;Deptof Chemistry,FloridaStateUniversity,Tallahassee FL 32306-3006 Detection of PAID in Solid Environmental
ORGANIC
ANALYSIS
Abstracts are arranged alphabeticalIy byfirst author TPE TPE TPE TPE TPE TPE TPE TPE TPE TPE TPE TPE TPE TPE TPE TPE
Hydrocarbons in Meat and Seafood Matrices by SFE/Off-Line GCMRMS; *Alleyne, Carl S.;Verigin; Victor; Mori, Brian;HealthProtectionBranch,HealthCanada,Bumaby,B.C., CanadaV5G 4P2 F. Aladar;EISaid,Kathleen;Jester, Proflavine Derivatives for Mass Spectrometric Identification in Fish.; l Bencsath, EdwardL. E.; FoodandDrugAdministration,Gulf CoastSeafoodLab.,DauphinIsland,AL Study of Sesquiterpene Lactones Using Mass Spectrometry; *Campbell, James A.; +*Kelsey,Rick G.; PacificNorthwest NationalLaboratory Negative Ion CI with an External Source Ion Trap GClMS for the Analysis of Triglycerides; *Farmin,Steven; l l Woffendin,Gary; Conoley, Meredith;Finnigan, AustinTX 78728 GC/MS Chiral Analysis of Enantiomeric Drugs Amenable to GC Separation; *Getek,T.A.; Grill, A.G.; Hua,T.; Hariharan,S.;BioanalyticalR&D, ForestLab,220SeaLane,Farmingdale, NY 11735 Multispectral Identification of Oxidation Products of Glycols and Glycol Ethers; *Green,JohnGlass;Kao,Jen-Hsiang; TheDow ChemicalCompany,Louisiana Division,Plaquemine, LA 70765-0400 A Fast CC/MS/MS Method to Quantitate Free Phytosterols; *Jiu Ai, ; Research & Development, UST,800Harrison Street,Nashvile,TN 37203 Methylamine in Methane: Improved CI Reagent Gas for Molecular Weight Determinations; *Little, James; Eastman ChemicalCompany,Kingsport,TN Novel Pyrolysis (PY)-GC/MS Techniques for the Characterization of Additives in Hardened Concrete; *Mabud,Abdul; Jeknavorian, Ara; Barry,E.; Litzau,Jonathan;W.R.Grace& Co, Washington Res.Cent.,7500GraceDr., Columbia,MD 21044 Identification of a Process Impurity in a Pharmaceutical Raw Material ; *Magin, Don; Whitehall-Robins Analytical Development, Richmond,VA TMAH Thermochemolysis/GC-MS Applied to Structural Investigations of Lignin; *Minard, Robert;Dible, Scott; Sewell,Tam;Nanny,Mark; Hatcher,Pat;PennStateUniversity Quantitative Analysis of Fluorinated Ethylchloroformate Derivatives of Dipeptides Using GC/MS; l Moini, Mehdi; Cao, Ping;Universityof Texasat Austin,Austin A GC/MS and GC/MS/MS Study of Deuterium Exchange in Imines; *Organ,Andrew;Thorn,Catriona;Lee,Mike; **Mabon, Ross;SmithKlineBeecham Pharmaceuticals, HarlowUK Volatile Organic Composition in Blueberry; *Overton,SantfordV.; Manura,JohnJ.; ScientificInstrumentServices,Inc., Ringoes,NewJersey08551 Study of the polymeric part of archaeological adhesives; * Rolando,Christian;Regert,Martine;Menu, Michel; Houze, Armelle;Delacotte,Jean-Michel;EcoleNormaleSuperieure, Departement deChimie,PARIS(FRANCE) Rapid Analysis of Volatile Flavor Compounds in Horticultural Produce Using SPME and GCTOFMS; *Song,Jun; Gardner,Ben; Holland,John;Beaudry,RandyM.; MichiganStateUniversity Analysis of Polycyclic Aromatic
PRELIMINARY
TPE TPE TPE TPE
401
PROGRAM
of diterpenoid Pinnceae resins in Old Master’s paintings.; *van denBerg,KlausJan;Pastorova, Ivana;Spetter, Leo; Boon,JaapJ.; FOM Institutefor Atomic andMolecularPhysics,MOLART project An MS/MS Investigation of Organic Salts; *Wang,Jia-shen; ClairolInc., Stamford NEW SILYL DERIYATIYES FOR THE DETERMINATION OF ALCOHOLS BY GCIMS; *Zaikin, Vladimir; Shmatko,Michael;**Mikaya, Anzor; Instituteof Petrochemical Synthesis. LeninskyPr.29,117912,Moscow,Russia Negative ion chemical ionization/CAD studies of some aryl pentafluorobenxoates (part II); *Zhang,Mei-Yi; Molinary, Nick; Cantone,Joe;Cingue,Teresa;Ghan,Kelvin; Sisenwine, Samuel;Wyeth-AyerstResearch, CN 8000,Princeton,NJ Oxidation
08543
CARBOHYDRATES
Abstracts are arranged ak@habetically by fmt author TPF TPF TPF TPF TPF TPF TPF TPF TPF TPF TPF TPF TPF TPF TPF TPF TPF TPF TPF TPF
Investigations of Complex Oligosaccharides from Human Milk; *Bahr,Ute; Pfenninger, Anja; Karas,Michael; **Stahl, Bemd;Fir&e,Bemdt;Sawatzki,Guenther;JWGoethe-Univ.,Div. for Instrum.Analyt. Chem.,60590Frankfurt, Germany Characterixation of PMP labeled oligosaccharides with MALDI TOF and LC ES1 mass spectrometry.; DeBarbieri, Barbara;Ma, Yuemai;Pan,Yu-ChingE.; *Michel, Hanspeter; RocheResearch Center,HotIhutnn-LaRoche,Inc., Nutley, NJ MALDI
07110 Methylation
Analysis of Oligosaccharides Revisited: CIMSlMS of Permethylated Ethyl-Glycosides; *Damon,Bruno; Dubreucq,Guy; De Hoffmann,Edmond;UniversitedesSciences et Technologies deLille, Villeneuved’Ascq,France Analysis of Complex Sugars in Synthesis; +Dubay,George;Debenham, John;Rodebaugh, Robert;Fraser-Reid, Bertram; Dept.of Chemistry,DukeUniversity,Durham,NC, 27708-0347 Characterization of a Haemophilus Carbohydrate Epitope Expressed as a Chimeric LPS in E. coli; Gibson,Bradford; *Phillips,Nancy;Engstrom,Jeffrey;**Apicella, Michael;Universityof California,SanFrancisco,CA 94143 PeterL.; vanVeelen,PeterA.; deVries, Synthetic sulfated oligosaccharides: Ionspray and MALDI compared; l Jacobs, Marcel P.; Dreef,Marijke M.; AKZO Nobel,N.V. Organon,ScientificDev.Group,Oss,TheNetherlands High- and Low-energy Collision -Induced Dissociation of Glycosphingolipid for Structural Elucidation; *Kasama, Takeshi;Tadano-Aritomi,Keiko; **Handa,Shizuo;Ishizuka,Ineo;Lab.Biomed.Analysis,Tokyo MedicalandDental University,Tokyo FABMS (LSIMS), ESIMS and CID-MS/MS, as Guiding Tools in Glycoconjugate Synthesis; *Kurono,Sadamu; Ohashi, Yoko; Neumann,Klaus;Tamura,Jun-ichi;Ogawa,Tomoya;Nagai,Yoshitaka;TheInstituteof PhysicalandChemical Research (RIKEN), Wake-shi Structural Analysis of Chromophore-Labeled Disaccharides by Liquid Chromatography/Mass Spectrometry; *Li, D.T.; Her,G.R.; Department of Chemistry,NationalTaiwanUniversity,Taipei,Taiwan,R.O.C. Derivatixed Trisaccharides under LSIMS, MS/MS and MALDI-TOFMS Conditions; l Perreauh, Helene;Costello, CatherineE.; Massachusetts Instituteof Technology,Cambridge, MA Detection of a non-covalent oligosaccharide antigen-antibody complex by ES1 mass spectrometry; *Peter-Katalinic, Jasna;Green,BrianN.; Ashcroft,AlisonE.; Narang,SaranA.; Young,N. Martin; MacKenzie,Roger;Altman,Eleonora; Bundle,David R.; Physiological Chemistry,Universityof Bonn,D-53115Bonn,Germany Stabilisation of oligosaccharides containing sialic acids for examination by MALDI; Powell,Andrew;*Harvey, David J.; GlycobioiogyInstitute,Department of Biochemistry,Universityof Oxford Analysis of flavonoids and related phenolics from hops (Humulus lupulus) by HPLC-MS-MS; *Stevens,JanF.; Kim, Hoon-Joo;Deinzer,Max L.; Department of AgriculturaiChemistry Multiple
Neutral Alkali Halide Attachments
onto Oligosaccharides
in Electrospray
Mass Spectrometry;
*Striegel,
AndreM.; Timpa,JudyD.; Piotrowiak,Piotr; Cole,RichardB.; Department of Chemistry,Universityof NewOrleans,New Orleans,LA’ 70148 Simple and Rapid Purification of ABDEAE-derivatized Oligosaccharides for the Sensitive MALDI-MS; *Tambara, Yanet;Takao,Toshifumi;**Fukuda,Hiroyuki; Fukuda,Masafumi;Shimonishi, Yasutsugu;Institutefor ProteinResearch, OsakaUniversity,Suita,Osaka,Japan Yoshiko;Gu,Jianguo;Research N-glycan Structures of a Small Proteoglycan Decorin, * *Wada,Yoshinao;Nakayama, Institutefor MaternalandChildHealth(BOSHI),Osaka,Japan MALDI-TOF MS of Recombinant ESelectin and PECAM Oligosaccharides; *Watson,Eric; Bhide,Anjali; Shah, Bhavana;Karan-Tamir,Barbara;Leidli, Christopher; Lin, Chi-Hwei;Zukowski,Mark; AmgenInc. Boulder,CO-80301 Sequence Analysis of Heparins by Nitrous Acid Degradation Combined with MALDI Analysis; *Wolf, Susan;Biemann, Klaus;Massachusetts Instituteof Technology Electrospray Ionization and Collision Induced Dissociation of Oligosaccharides in the Negative Mode; *Ye, Song; Reinhold,BruceB.; Reinhold,VernonN.; Costello,CatherineE.; BostonUniversityMedicalSchool,Boston,MA 02118 Highly sensitive structure analysis of oligosaecharides; *Zhao.Yingming;Qin, Jun;Chait,BrianT, The Rockefeller University, 1230York Avenue,NewYork, NY 10021 CLINICAL AND BIOMEDICAL MS
Abstracts are arranged alp~abeticai& byflrst author TPG TPG
EC-LC-ES1
MS: Electrochemisty
combined with Liquid Chromatography
and Electrospray
Ionixation
MS.;
*Bacynskyj, Lubomyr;Structurai,Analytical andMedicinalChemistry,Pharmacia andUpjohn,Inc. A HPLC-Bioassay-PSDMALDI Strategy for the Identification of Vasoactive Compounds; Bahr,Ute; l Karas,Michael; Russ,Thomas;**Schlueter,Hartmut;Luo, Jiankai;JWGoethe-Univ.,Div. for Instrum.Analyt. Chem.,60590Frankfurt, Germany
402 .
UI-H
ASMS
CONFERENCE
ON
MASS
SPECTROMETRY
* TPG TPG TPG TPG TPG TPG TPG TPG
TPG TPG TPG TPG TPG TPG
TPG TPG TPG TPG
TPG TPG TPG TPG TPG TPG
TPG TPG TPG
Identiflcntion of Two Species from the Demethylation of Derivetized Free Cernitine in GCIMSIMS; *Carlson, Shannan; l *Borum, Peggy; Johnson, Jodie; Yost, Richard; Department of Chemistry, University of Florida An enentioselective CC-MS method for the determination of Milnecipren end its metebolites in plesme; *Dr. Michaelis, Karl; Agvq Ufik; Zick, Michael; Dr. Schmid, Bernhard; **Dr. Puozzo, Christian; L.A.B. GmbH, Neu-Ulm, Germany Mess Spectrometric Analysis of Texol end Anelogues; Emond, Christopher; *Eigendorf, Guenter; University of British Columbia, DeparCment of Chemistry Identification of Flevonoid(s) in Wine end Crepe Products Implicated in Vesorelexetion Effects; *Fries, David; O’MaIley, Rebecca; **Jantzen, Paul; Fitzpatrick, David; U. South Florida, Dept. of Chemistry-Tampa, FL Quentitetion of [180]- end [lJC]-Cholesterol Isotopomers by Negative Chemical Ionizetion CC/MS; *Hachey, David L.; Clarke, Lucinda L.; Liu, Dan; Heird, William C.; Wong, William W.; Baylor College of Medicine, Houston, TX 77030 Trace detection of muremic acid, a bacterial chemical marker, in human body fluids using GC-MS-MS; *Harrelson, Davis; Fox, Karen; Fox, Alvin; University of South Carolina, School of Medicine, Columbia, South Carolina Multi-dimensional Analysis of Complex Biological Mixtures Using GC/TOFMS with Time Array Detection; *Holland, John; Gardner, Ben; Greene, Vaughn; Grainger, James; **Barr, John; Patterson, Don; Michigan State University Mess Spectrometric Analysis of Morpholino Phosphorodiemidete Oligomers; *Hudziak, Robert M.; Weller, Doreen L.; Weller, Dwight D.; **Barofsky, Elisabeth; Barofsky, Douglas F.; AntiVirals Inc., 4575 SW Research Way, Suite 200, Corvallis, OR 97333 Identification of Legionella Bacteria using MALDI-TOF for Detection of PCR Products; *Hurst, Gregory B.; Doktycz, Mitchel J.; Vass, Arpad A.; Buchanan, Michelle V.; Oak Ridge National Laboratory Mess Spectrometry end Site-Specific Synthesis of Modified Oligodeoxynucleotides; *Iden, Charles R.; Department of Pharmacology, University at Stony Brook, Stony Brook, NY Metal Ion Interactions with Nucleic Acids es Probed by ESI-MS.; *Ikonomou, M. G.; He, T.; Bertrand, M. J.; Anastassopoulou, J.; Paul, G. J. C.; Institute of Ocean Sciences, Contaminants Science Section, Sidney, B.C. Analysis of Porphyrins in Biological Materiel by Mess Spectrometry.; *Jones, Russell; Lamb, John; Luo, Jin-Li; Lim, Chang Kee; MRC Toxiology Unit, Leicester, UK Analysis of Bile Acids by LClESUMSlMS using e Benchtop Quadrupole Ion Trap; *Josephs, Jonathan; Sweeney, Matthew; Gale, David; Sanders, Mark; Finnigan MAT, San Jose CA Development of strategies for Lipid A characterization by methods of mess spectrometry.; *Kaltashov, Igor; Walker, Kathleen; Doroshenko, Vladimir; Cotter, Robert; Qureshi, Nilofer; Raetz, Christian; Pharmacology, Johns Hopkins University Medical School, Baltimore MD Structural Elucidation of New Polyether Antibiotics by Tandem Mess Spe&trometry; *Kim, Young Hwan; Yoo, Jong Shin; Korea Basic Science Institute, Taejon, Korea The Identification end Charecterisetion of Bile Acids by LC/Electrosprey/MS/MS.; l Lepage, Guy; **Major, Hilary; Hutton McKenna, ThCrkse; Preece, Steve; HBpital Ste-Justine, Universitt de MontrCal, MontrkaI, H3T 10, Canada. Identification of Degradation Products and Trace Contaminants of Mycophenolic Acid Mofetil by LCMS; *Lustig, David A.; Roche Bioscience, Palo Alto, CA Mess Spectrometry of 3,4- end 3.5Dicaffeoylquinic Acids and Related Analogs; l Miketova, Petra; Schram, Karl H.; Timmermann, Barbara N.; Liu, Yong-Long; Valcic, Susanne; College of Pharmacy, University of Arizona, Tucson, Arizona 85721 Determination of EDTA end its metal chelates in human blood by ion spray CEIMS; *Sheppard, Robin; Henion, Jack; Analytical Toxicology, Cornell University, Ithaca, NY Point Mutation Detection by Laser Desorption Mess Spectrometry; *Taranenko, Nelli; Matteson, Karla; Chung, Chris Nancy; Zhu, Yi-Fei; Chang, L. Y.; Allman, Steve; Haff, Larry; Martin, Steve; Oak Ridge National Laboratory Investigation of the Production of cADPR end cGDPR by ADP-ribosyl Cyclese using ESIILCIMS; *Warrack, Bethanne M.; Hail, Mark E.; Green, David W.; Wang, Paulina; Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ Genetic diagnosis with PCR end ESI-MS; Terunuma , Hideya; *Tsuneyoshi, Toshihiro; Naito, Yasuhiro; Ishikawa, Keiichiro; Koga, Yoshinori; Baba, Shozo; Prockop, Darwin J.; Arakawa, Ryuichi; Shizuoka Inst. of Science and Technology, Fukuroi 437, Japan Structural Elucidation of C-GIucosyl Chromones from Aloe barbedensis Miller; l Weintraub, Susan; Salman, Mohammad; Williams, Robert; Hutter, John; Satsangi, Neera; Streeper, Robert; Stavinoha, William; The University of Texas Health Science Center, San Antonio TX Factors which effect the reproducibility of pyrolysis mess spectra for microbiological samples; *Wilkes, Jon G.; **Voorhees, Kent. J.; Rafii, Fatemeh; Sutherland, John B.; Lay, Jackson O.,Jr. ; Freeman, James P.; National Center for Toxicological Research, Jefferson, AR 72079-9502 Application of IonSprey Ionization Quentitetion Gueifenesin (3-(2-methoxyphenoxy)-1,2-Propenediol); *Winslow, L.D.; Schomo, Karl S.; Kansas City Analytical Services Quantitative LCYMWMSDetermination of S-Fluorourecil, Uracil, Tegefur, end Lecucovorin in Plasma; *Wu, Henry; Henion, Jack, **Kaul, Sanjeev; Wang, Karen; Edom, Richard; Advanced BioAnalyticaI Services DNA Sequencing by Laser Induced Fragmentation in MALDI-TOFMS; *Zhu, Yi-Fei; Taranenko, NelIi; Allman, Steve; Chen, Chung-Hsuan; Oak Ridge National Laboratory
DRUG METABOLISM - QUANTITATIVE STUDIES Abstracts are arranged alphabetically byjirst author TPH
Quentitetive determination of Love&tin active metebolite by e new IiPLC-negative ion ESI/MS; Abiti, Santiago; +GelpI, Emilio; Institute de Investigaciones Biomddicas. IIBB-CSIC, Barcelona
Joaquln; Ruiz,
PRELIMINARY
TPH
403
PROGRAM
LC/MS/MS
Determination
of Bisphosphonater
in Human Urine; *Anderson,Melissa;**Lancas,Fernando;Henion,Jack;
Analytical Toxicology,CornellUniversity,Ithaca,NY 14850 TPH
Analysis of 8,9,11-Trio1
Eicosatrienoic
Acid, A PGHS Derived Urinary
Metabolite;
*Arora, Vinod; Garner.Carlos0.;
Belas,FrankJ.; Blair, Ian A.; VanderbiltUniversitySchoolof Medicine TPH
CEIMS-Ion
Trap Determination
of Bisphosphonates
in Human Urine, * *Bach,Gloria,;Henion,Jack;Analytical
Toxicology, CornellUniversity,Ithaca,NY 14850 TPH TPH TPH TPH TPH TPH TPH TPH TPH TPH TPH
Determination of a New Estrogen in Human Serum Using NCEGCIMSIMS; ‘Brudny-Kloeppel,Margarete; Baumann,Andreas;Madetzki,Christian;Kuhnz,Wilhelm;Instituteof Pharmacokinetics, ScheringAG, Berlin,Germany Quantitative Analysis of the PAF Antagonist, SR 27417, in Human Plasma Using LC-MS/MS; *Buhrman.DeborahL.; Price,PiperI.; Drozd,Marion L.; Newton,JohnF.; Herbert,JohnM.; Ellames,GeorgeJ.; Rudewicz,PatrickJ.; Clinical Pharmacokinetics & Metab.,SanofiResearch Division,Malvem,PA Low Level Determination of a Novel Caxasteroid & its Acid Metabolite in Plasma & Semen by LC-MS/MS; *ChavezEng,Cynthia;Constanzer, Marvin; Matuszewski,Bogdan;Carlin,J.; Graham,D.; Merck Research Laboratories, WestPoint PA andRahway,NJ Quantitative Analysis of Steroids in Complex Matrices by LCIMSIMS on an Ion Trap; +Cunniff,Jack;Tiller, Phillip; Land,Adrian; Vasconcellos, Tom; Waketield,Mike; FinniganMat, SanJose,CA U.S.A Quantitation of 264W94, a Possible Hypocholesteremic Agent, in Rat and Monkey Plasma by LC/MS/MS; *Dunn,John; Otto, Victoria; Kenney,Kathryn;Allsup,Thurman;Marr, Harry; GlaxoWellcome Research TrianglePark,NC ’ Identification of the urinary metabolite S-NAC-2-ene VPA in patients on VPA therapy using CC/MS; *Gopaul,Sashi; Tang,Wei; Mutlib, Abdul; Farrell,Kevin; Abbott, Frank;Universityof BritishColumbia,Vancouver Multiple Simultaneous Quantitative LCIMS: A New Tool To Support Drug Candidate Selection; *Hamiiton,Brenda; Abolin, Craig;SandozResearch Institute,EastHanover Quantitative Drug Metabolism Studies Using LCKRIMS and LC/ESI MS/MS; Hsieh,Feng-Yin;*Goldthwaite,Charles; Yeola,Suresh;Chaudhary,Ajai; Mayol, Robert;Klunk, Lewis;Blair, Ian; VanderbiltUniversitySchoolof Medicine, Nashville,TN Most sensitive quantitative analysis of metformin by LC-MS/MS in human plasma; *Kinzig, Martina;RYsing,Guido; Haag,Armin; S&gel,Fritz; IBMP - Inst.f. Biomed.andPharmaceut. Res.,NYmberg-Heroldsberg, Germany LC/MS/MS Determination of Carnitine and Acetylcarnitine in Human Plasma and Urine; l Lowes,Steve;**Bimboeck, Herbert;Henion,Jack;AdvancedBioAnalyticalServices,Ithaca,NY 14850 Quantitative
Simultaneous
Determination
of O-Propylene Glycol Methyl Ether & 2-Methoxypropionic
Acid by GC/TKUMS;
TPH
*McNett, Debra;Hansen,Steven;Bartels,Michael;TheDow ChemicalCompany,Midland,MI Pharmacokinetics and Tissue Distribution of (E,Z)-2,3’-Diene VPA.in the Rat Brain; *Moshenko,JaniceL.; Ma, Steven; Abbott, Frank;Universityof BritishColumbia,Vancouver,BC, Canada Automated SPE in “96 well” microtitre plate format for high throughput bioanalysis using LC-MS-MS; *Pleasance, Stephen;Biddlecombe, RobertA.; Jones,AnneE.; GlaxoWellcome Electrospray LC-MS/MS for Quantitative Analysis: A Study of Ion Suppression; l Rudewicz,PatrickJ.; Vekich, Sylvia V.; Luo, WendyC.; Allergan,Irvine Applications of Pentafluorobenxyl Chloroformate Derivatixation for ECNI I MS; *Simpson,JohnT.; Markey,SanfordP.; NationalInstituteof MentalHealth,Bethesda Simultaneous Determination of Steroids in the Low Picogram Range from 1 mL of Serum by LC-MS-MS; *Stuting, HansH.; **Breau,Alan; Huang,Qingtao;LeBlanc,Yves;LaboratoryCorporationof America- ClinicalTrialsDivision, Raritan,NJ Quantitation of Pharmaceutical Products using Quadrupole and Ion Trap Mass Spectrometers; *Waketield,Michael; **Newton,John;Burton,Regina;Folk, Brian;Buhrman,Debra;Price,Piper;Wu, Danlin;Land,Adrian; FinniganMAT San Jose,CA Elucidating the Renal Metabolism of EB 1089, a Vitamin D Analogue, by Capillary LC-ESI-MS; *Weiskopf,AndrewS.; Vouros,Paul;Weinstein,Edward;Siu-Caldera, Mei-Ling; Reddy,G. S.;The BarnettInstitute,Northeastern University, Boston,MA Quantitative Determination of RPR 102681 in Human and Monkey Plasma using Ion Spray LCIMS; *Wu, HenryY.; Mulvana,Daniel;Henion,Jack;**Gilbert, Mary; AdvancedBioAnalyticalServices,Inc. Ithac,NY LCMS Quantitation with Electrospray Ionization; *Zhang,Rong;Schoen,Alan; Campbell, Clay; FinniganMAT, SanJose
TPI
LASER DESORPTION - FUNDAMENTALS Abstracts are arranged alphabetically byfirst author Laser Desorption Mass Spectrometry from Frozen Water Solutions Using a 3.8 urn YAGlOPO
TPH TPH TPH TPH TPH TPH TPH TPH
Laser System;
**Alimpiev, Sergey;Dratz, Edward;*Sunner,Jan;MontanaStateUniversity,Bozeman,MT TPI TPI TPI TPI TPI
Laser Desorption Ionization from Frozen Water and Organic Solutions; **Alimpiev, Sergey;Chen, Yu-Chie;Shies,Jen-taie;Dratz,Edward;*Sunner,Jan;MontanaStateUniversity,Bozeman.MT The Use of Membranes/Films and Coated Membranes/Films in MALDUMS; l Bai, Jian;Liang,Xiaoli; Zhu, Yongdong; Cain,TeresaC.; Lubman,David M.; Department of Chemistry,TheUniversityof Michigan,Ann Arbor, MI 48109 Characterixation of Two New MALDI Matrices; *Bai, Jian;Liang,Xiaoli; Liu, Yan-Hui;Zhu, Yongdong;Lubman,David M.; Department of Chemistry,The Universityof Michigan,Ann Arbor, Mich 48109 Characterisitcs Of Several New Alpha Substituted Cinnamic Acids As MALDI Matrices; *Brown, Robert;Feng,Jinhua; UtahStateUniversity,Logan,UT 84322-0300 Elemental sulfur as a matrix for MALDI-TOF mass speetrometry; l Brune,DanielC.; Dept.of Chem.& Biochem.. Arizona StateUniversity,TempeAZ 85287-1604 Surface-Assisted
404 .
44TH
&MS
CONFERENCE
ON
MASS
SPECTROMETRY
* TPI
Evaluation
of Hydrophobic Interactions of the Matrix and Anrlyte in MALDI; TexasA&M University,CollegeStation
*Campo, KarenK.; Russell, David H.;
TPI
Applications
(SALDI); l Chen,Yu-Chie;Shies,
of Activated
Carbon Surface Assisted Laser Desorption Ionization
Jentaie;Sunner,Jan;MontanaStateUniversity TPI
Surface-Assisted
Laser Desorption
Ionixation
(SALDI)
Mass Spectrometry
from Liquid
Solutions; *Chen,Yu-Chie;
Dratx,Edward;Sunner,Jan;Department of ChemistryandBiochemistry TPI
Effects of ammonium
salts as co-matrices for the analysis of oligonucleotides
by MALDI; l Cheng,S-W.;Chan,T-W.
Dominic;TheChinese Universityof HongKong,HongKong TPI
Probe Surfaces for Desorption
of Bioactive Arrays Tethered with Photolytic
Devices; l Ching,Jesus; Voivodov, Kamen;
Hutchens,T. Willam;Universityof California,Davis TPI TPI TPI TPI TPI TPI TPI TPI TPI TPI TPI TPI
Mass Spectrometry of Polynuclear Transition Metal Clusters; *Dale,Michael;Dyson,Paul;Johnson, Brian;Langridge-Smith, Patrick;Yates;Hilary; Ferrige,Tony; TheUniversityof Edinburgh,Edinburgh Perrhenate Surface Bombardment in SIMS: Disappearance Cross Sections and Desorption Mechanism; +Groenewold, Gary; Gianotto,Anita; Olson,John;Ingram,Jani;Appelhans, Anthony;Dahl,Dave;Delmore,Jim;IdahoNational Engineering Laboratory,IdahoFalls,ID Matrix assisted laser desorption/ionixation of synthetic polymers with axo-compound matrix; *H. M. Donny, Liu; Urs. P., Schlunegger; Instituteof OrganicChemistry,Universityof Bern,Bern/Switzerland Chemical and Physical Processes in Aerosol MALDI; *He, Lin; Wei, Gang;Murray, Kermit;EmoryUniversity,Atlanta Frozen Liquid Matrices for MALDI Time-of-Flight Mass Spectrometry of DNA Oligomers; *Hunter,Joanna M.; Lin, Hua;**Becker,Christopher H.; SRI International,MenloPark,CA 94025 MALDI of Individual Size-Selected Microparticles; *Johnston, Murray; Mansoori,Bashir;Universityof Delaware,Newark, DE Studies on the selection of new matrices for UV Matrix-Assisted Laser Desorption/Ionixation MS; *Krause,JoemL.; Schlunegger, UrsP.; Department of OrganicChemistry,Universityof Beme,Beme,Switzerland Fragmentation of Sulfated Dyes, Drugs and Sugars Desorbed as Noncovalent Complexes upon MALDI; *Rhomberg, Andrew;Biemann,Klaus;Massachusetts Instituteof Technology Polyphenolic Compounds as New MALDI Matrices; *Sumner,Lloyd W.; Shields,SharonJ.; Wolf, BarbaraP. ; Russell, David H.; TexasA&M Univ., Laboratoryfor BiologicalMassSpec.,CollegeStation,TX Comparing SIMS with Laser DesorptionlPhotoionixation for Molecular Surface Analysis; Trevor, JenniferL.; *Hanley, Luke; Lykke, KeithR.; **Pellin,MichaelJ.; Universityof Illinoisat Chicago Off-line coupling of CE and MALDI MS: Continuous sample deposition on a matrix-precoated membrane; *Zhang, Haiying; Caprioli,Richard;Universityof TexasMedicalSchool,Houston,Texas77030 Detection of DNA by MALDDMS: Sample preparation-purification of DNA samples; *Zhu, Yongdong;Bai, Jian;Liu, Yian-hui;Liang,Xiaoli; Lubman,DavidM.; Dept.of Chem.TheUniv. of Mich. Ann Arbor, MI 48109-1055 SPRAY IONIZATION - APPLICATIONS Laser Desorption
Abstracts are arranged alphabetically byj7rst author TPJ TPJ TPJ TPJ TPJ TPJ TPJ TPJ TPJ TPJ TPJ TPJ TPJ TPJ
Diamine in Bis(23’-binvridine) Comolexes of Ruthenium usine On-Line ES-MS: *Arakawa Ryuichi;Mimura,Shin-ichi;Matsubayashi, &n-et& Mat&, Takekiyo;Department of AppliedChemistry,OsakaUniversity Techniques for Automated Molecular Weight Measurements Using Electrospray Ionization MS; *Covey, Tom; McLean, Matt; Liu, Charles;Bonner,Ron;Burton,Lyle; SCIEX,Concord,Canada Analysis of Transition Metal Picolinate Complexes by Electrospray LCIMS, GC/MS, and ICP-AES; *Flurer, Rick; Mulligan, Kevin; Barnes,Barbara;Satzger,Duane;ForensicChemistryCenter,U.S. FDA, Cincinnati,OH Accurate mass determination of agrochemicals and their metabolites using APCDMS; *Fujiwant,Hideji;Monsanto Company,St.Louis,Missouri Electrospray Mass Spectrometry of Borane Salts: Maximum Results with Minimal Effort; *Hop,ComelisE.C.A.; Gaines,DonaldF.; Saulys,DovasA.; ChemistryDepartment, Universityof Wisconsin-Madison, Madison,WI Analytical Strategies for Rapid Molecular Formula Determination Using High Resolution ES1 MS; *Klohr, Steven; Whitney, Jeffrey;Rourick,Robyn;Volk, Kevin; Muenster,Helmut;Kerns,Edward;**Lee,Mike; Bristol-MyersSquibb, Wallingford,CT 06492 FT-ICR studies of sandwich-type (phthalocyaninato)(porphyrinato)Lanthanide(III) complexes using ESI; l Lau, Rebecca L.C.; Ng, DennisK.P.;Chan,T-W. Dominic;The Chinese Universityof HongKong, HongKong The use of IS-MS in the characterixation of metallothioneins; *Le Blanc,J.C.Yves; **Blais,Jean-Simon; PE-Sciex,71 FourValley Drive, Concord(Ontario)L4K 4V8,Canada Analyses of Cu(I) Complexes via ES1 Mass Spectrometry: Implications for Organocuprate Reagents; Lipshutz,Bruce H.; James,Brian;*Stevens,Kirk L.; Pavlovich,James G.; Universityof CaliforniaSantaBarbara Accurate Mass ES1 on a Magnetic Sector Mass Spectrometer; *Moore,Colin;UniroyalChemical Company,Inc., Electrospray Fourier Transform Mass Spectrometry for the Analysis of Biopolymers; l OConnor,PeterB.; Duursma, MarcC.; Heeren,RonM.A.; Boon,JaapJ.; FOM Institutefor Atomic andMolecularphysics A Comparison of Quadrupole, Sectors and Ion-Trap Analysers to Ascertain Multicharged-Ions Assigments; *Picard, Claudine;Uzabiaga,Francoise;Petitou,Maurice;Picard,Claude;Galaup,Chantal;**Porter,Chris;Sanders, Mark; Pugh, Jonathan;SanofiRecherche andCNRSURA 471ToulouseFrance ESDMS of Organometallic Compounds on an LCiMSIMS Ion Trap Mass Spectrometer; *Sweeney,Matt; Josephs, Jonathan;Gale,David; Sanders, Mark; FinniganMAT, 355River OaksParkway,SanJoseCA, 95134 Electrospray Ionixation Mass Spectrometric Analysis of Oxo-Bridged Manganese Dimers; l Weintraub,Susan;Ciringh, Yangzhen;Horwitz, Cohn;TheUniversityof TexasHealthScienceCenter,SanAntonioTX Photolysis of Coordinated
PRELIMINARY
TPJ TPJ
TPK TPK TPK TPK TPK TPK TPK TPK TPK TPK TPK TPK TPK TPK TPK TPK TPK TPK TPK TPK TPK
TPL TPL TPL TPL TPL TPL
PROGRAM
ESI-MS
405
of Orgnnometallic Compounds; * Wolf, BarbaraP.; Shields,SharonJ. ; Sumner,Lloyd W.; Russell,DavidH.; TexasA&M Univ., Lab.for BiologicalMassSpectrometty,CollegeStation,TX Accurate mass and MS/MS analyses of Combinatorial Chemistry products by Micro Electrospmy;*WooBitt, A. R.; Bateman,R. H.; Green,M. R.; Ordsmith,N. H. R.; Pugh,D.J.; VG Organic,Manchester, M23 9LZ, UK DNA/RNA STRUCTURE dkADDUCTS Abstracts are arranged alphabetically byflrst author The Effect of Backbone Charge on the Collision-Induced Dissociation of Oligonucleotides; *Bartlett, Michael; McCloskey,James; Griffey, Richard;Department of MedicinalChemistry,Universityof Utah,SaltLakeCity, UT Analysis of Oligonucleotides Bound to Positively Charged Surfaces; +Bruenner,Bemd;Hutchens, T. William;University of California,Davis Davis Drug-DNA Interaction Studies Using Electrospray Ionization Mass Spectrometry; *Gao,Quanyin;Cheng,Xueheng; Smith,RichardD.; **Yang, CatherinF.; Goldberg,Irving H.; PacificNorthwestNationalLaboratory Electrophore Mass Labels for TOF-MS DNA Sequencing; *Giese,R.; Xu, L., Wang,P.; Bian,N., Abushamaa, H.; Wang, Z., Magiera,D.; Murugaiah,V., Pillai, S.;Laukien,F., Park,M. I-2; Church,G., Kutney,L. 1-3;Smith,D., Carson,S.I-4; Northeastern Univ., BrukerInstrum.,HarvardMed.Sch.,GenomeTherapeutics HPLC and ES1 Mass Spectrometric Sequencing of Three Methyl-oligonucleotides; Glover, RobertP.; *Sweetman, Gavain M.A.; MRC ToxicologyUnit, Leicester,UK Correlation between ES-MS charge states for oligonucleotides and solution counterion condensation; l Griffey, Richard; Greig,Michael;Sasmor,Henri;IsisPharmaceuticals, Carlsbad, CA Metal(I1) Ion Complexes of ACC Formed by Electrospray Ionization; *Hamilton,Jill; Adams,Jeanette; Department of Chemistry,EmoryUniversity,Atlanta,GA 30322 Gas-Phase Chemistry of Metal(H) Ion Complexes of Trinucleotides; *Hamilton,Jill; Adams,Jeanette; Department of Chemistry,EmoryUniversity,Atlanta,GA 30322 LCYESI MS/MS assay for 7,8-dihydro&oxo-2’-deoxyguanosine (8-oxo-dG); l Kowalski,E.M.; Chaudhary, A.K.; Blair, I.A.; VanderbiltUniversity,NashvilleTN Chemical Sequencing of Oligonucleotides with Moditied Backbones Using Mass Spectrometry; Polo,LenoreM.; McCarley,Tracy D.; *Limbach,PatrickA.; LouisianaStateUniversity,BatonRouge,LA 70803 Detection of Non Covalent Interactions in Nucleic Acids using MALDI; *Lecchi,Paolo;Garland,Carl;Howard,Frank; Miles, Todd; Pannell,Lewis;Laboratoryof Analytical Chemistry,NIDDK, NIH, Bethesda, MD 20892-0805 Mass Spectrometric Methods for Genotyping; *Little, DanielP.; Higgins,G. Scott;Braun,Andreas;Damhofer,Brigitte; Leppin,Lorieta;Craven,Fiona;Koster,Hubert;Sequenom Instruments GmbH Analysis of Oligonucleotide Mixtures by ESI-MS Utilizing Charge-State Reduction; *Muddiman,DavidC.; Bruce,James E.; Pass-Tolic,Ljiljana;Smith,RichardD.; PacificNorthwestNationalLaboratory Further Investigation of Alkali Metal Ion Interactions with Nucleosides by LSIMS; *Paul,G. J. C.; Ikonomou,M. G.; Anastassopoulou, J.; Bertrand,M. J.; Universityof Montreal,Montreal GC/ECNCI/MS/MS Analysis of Elctrophore-labeled DNA Adducts; *Ranasinghe, Asoka;Scheller,Nova; Wu, Kuen; Swenberg, James;Universityof North Carolinaat ChapelHill Reduced Cation Adduction in Negative Ion ES1 Mass Spectra of Oligodeoxynucleotides; l Rieger,RobertA.; Iden, CharlesR.; Department of Pharmacology, Universityat StonyBrook, StonyBrook,NY Characterization by MALDI-TOFMS side-products in oligodeoxynucleotide synthesis; *Wang,Bing; Budman,Eva; Belenky,Alexei; Froim,Doriana;Cohen,Aharon;Hybridon,Inc. Characterization of Modified Oligonucleotides by Enzymatic Digestion and Ionspray Mass Spectrometry; l Wu, Huaiqin;Morgan,Ronald;Aboleneen,Hoda;Abbott Laboratories, Diagnostics Division,Abbott Park,IL60064 Optimization of Enzymatic Sequencing of Oligonucleotides with Ionspray Mass Spectrometry; l Wu, Huaiqin;Ghan, Clifford; Aboleneen,Hoda;Abbott Laboratories, Diagnostics Division,Abbott Park,II 60064 Synthesis of 13CS-adenine and 13C5-2’-deoxyadenosine for mass spectrometric studies of DNA-adducts; *Yeola, S.N.; Saleh,S.A.; Chaudhary,A. K.; Blair, I. A.; VanderbiltUniversity,Departments of ChemistryandPharmacology Trace Detection of Electrophores by EC-FTMS; *Zhang,Tianlan;VanOrden,Steven;Laukien,Frank;Huang,Yulin; Giese Roger;NorthEasternUniversity,Boston,MA ;PROTEINS AND PEPTIDES Abstracts are arranged alphabetically byflrst author Fred;Osbom,Blaire;Teffera,Yohannes; Isotopic differences in human growth hormone preparations; *Abramson, GeorgeWashingtonUniversity,Washington, DC Binding of Cu(I1) in Doubly Charged Ions of Angiotensin II Formed by Electrospray Ionlzation; *Adams,Jeanette; Sullards,Cameron;Department of Chemistry,EmoryUniversity,Atlanta,GA 30322 Hemorphin metabolism in blood and brain studied by microdialysislelectrospray mass spectrometry; *Andren,PerE.; Sanderson, Katarina;Nyberg,Fred;Dept.of Pharm.Biosciences, UppsalaUniversity,Uppsala,Sweden High Sensitivity Identirication of Proteins from SDS PAGE using In-Gel Digestion and MALDI-PSD; *Annan,Roland; McNulty, Dean;Carr,Steven;SmithKlineBeecham Pharmaceuticals Protein Identification on 2D Gels by Image Analysis, Capillary LC-MS and Tandem MS: Applications; *Amott, David; Stults,John;Genentech, Inc., SouthSanFrancisco, CA 94080 MALDI and ES1 MS to study binding sites for phenothiazine inhibitors of trypanothione reductase; Bolgar,Mark S.; *Itoh, Shinji;Gaskell,SimonJ.; Yin, Hong;Ghan,Cecil;Garforth,Jacqui;**Douglas,KennethT.; Fairlamb,Alan H.; MichaelBarberCentrefor MassSpectrometry, UMIST, Manchester,U.K.
406
.
44TH
ASMS
CONFERENCE
ON
MASS
SPECTROMETRY
* TPL TPL TPL
TPL TPL
TPL TPL TPL TPL TPL TPL TPL TPL TPL TPL TPL
TPL TPL
TPL TPL TPL TPL TPL TPL TPL TPL TPL TPL TPL
Regiospefific binding of PAH metnbolites to albumin: screening and characterization by LC-MS/MS.; *Brunmark, Per; Skipper, Paul L.; Tannenbaum, Steven R.; Wishnok, John S.; Massachusetts Institute of Technology, Cambridge, MA Analysis of Bacteriorhodpsin Cleavage Fragments by HPLC-ESI-MS and MS/MS; *Busman, Mark; Cowden, Lori B.; Knapp, Daniel R.; Dept. of Pharmacology, Medical Univ. of South Carolina, Charleston, SC Electrospray Ionisation Mass Spectrometry Study of FO Inhibitors Interactions with Ceroid Lipofuscin; Buzy, Anuelle; Ryan, Edward M.; Griftiths, David E.; *Jennings, Keith R.; University of Warwick, Department of Chemistry, Coventry CV4 7AL, UK Monitoring Enzymatic Reactions by Mass Spectrometry; Chavez, Rodrigo; Bothner, Brian; Strupp, Christian; Hilvert, Don; *Siuzdak, Gary; The Scripps Research Institute, La Jolla, California The charge remote loss of 60 Da from peptides containing an arginine residue at the C-terminus.; *Decry, Michael J; Summertield, Scott G; Buzy, Armelle; Jennings, Keith R; Department of Chemistry, University of Warwick, Coventry CV4 7AL, U.K. An unusual fragmentation pattern in the determination of the sequence of a cyclic peptide; Domingues, Pedro; *FerrerCorreia, A.J.V.; Mass Spectrometty Laboratory, Chemistry Dep., Aveiro University, Portugal High Sensitivity MS/MS and MALDI on a Tandem 4-Sector Instrument with a Scanning CCD Array Detector; *Finch, Jeffrey W.; Miki, S.; Koli, V.S. Kumar; He, Shou Ming; Orlando, Ron; JEOL USA Inc., I I Dearborn Rd., Peabody, MA 01960 Novel Derivatization Schemes For Collisional Activation Spectra Of Peptides; l Gedamke, Rich; Hail, Mark; DiDonato, Gerald; Lee, Mike; Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ Interpretation of peptide fragment ion intensities for a series of D- and L- amino acid isomers; l Goodlett, David R.; Gale, David C.; l *Crowther, Jonathan B.; Mukherjee, Tarit; Goodlett Scientific, Seattle WA Selective Sulfur-bond Cleavage in the Low-Energy CID of Disullide Linked Peptides; *Hailer, Ivan; Chait, Brian T.; The Rockefeller University, New York, NY I002 I Simplified MALDI-TOF peptide sequencing by combined Post Source Decay (PSD) and ladder analysis; *Hauer, Charles R.; **Kowalski, Paul; Roth, Karen; Stack, Robert; Wadsworth Center Examination of Metallothionein Isoforms in Drug Resistant Human Bladder Tumor Cells.; *He, Tao; **Hilton, John; Zaia, Joseph; Fabris, Daniele; Fenselau, Catherine; University of Maryland Baltimore County, Baltimore, MD Mass Spectrometric Characterization of Protein-Isocyanate Conjugates by Electrospray Ionization; *Hesso, Antti; Tomaeus, Jarkko; Pfaeffli, Pirkko; Vainio, Harri; Finnish Institute of Occupational Health , Helsinki, Finland LC-ESIMS and MALDI-TOFMS Peptide Mapping of the Tetanus Toxin C Fragment; *Hines, Harry; Brueggermann, Ernst; l *Sumpter, Terry; Toxinology Division, USAMRIID, Ft. Detric, Frederick, MD Structure Elucidation of OafPhytochrome A; *Jiang, Xiangyu; Lapko, Veniamin; Song , Pill-Soon; Smith, David; Department of Chemistry, University ofNebraska, Lincoln, NE68588 Electrospray Ionization Mass Spectrometry in Discovery of Scorpion Venom Neuropeptide Toxins; *Jones, A. Daniel; Lehmberg, Elisabeth; Moskowitz, Haim; Herrmann, Rafael; Nakagawa, Yoshiaki; Hammock, Bruce D.; University of California - Davis, Davis CA Does MS/MS always identify the modification sites in peptides ?; *Katta, Viswanatham ; Rohde, Michael F.; Amgen Inc. Thousand Oaks, CA-9 1320 LC-MS, CZEMS and LC-MS/MS investigation of protein tyrosine phosphatase inhibition by pervanadate; *Kelly, John; Huyer, Gregory; Ramachandran, Chidambaram; Kennedy, Brian; Merck Frosst Centre for Therapeutic Research, Kirkland, Qu bet, Canada CID of derivatized peptides analyzed on a sector instrument equipped with an orthogonal TOF analyzer; *Lindh, Ingemar; Griffiths, William J.; Bergman, Tomas; Sjovall, Jan; Karolinska Institutet, Stockholm, Sweden Sequencing isobaric peptides by the application of MSn analysis on an ion-trap mass spectrometer; *Maleknia, Simin; Corixa Corporation, 1124 Columbia Street, Seattle, WA 98104 Protein Sequence and Structural Studies Employing MALDI-High Energy Collision-Induced Dissociation; *Medzihradszky, Katalin; Yu, Zhonghua; Hall, Steven; Maltby, David; Burlingame, Alma; Mass Spectrometry Facility, University of California, San Francisco Characterization of Proteins Isolated from Cell Nuclei Using MALDI TOF MS and PSD Analysis; *Murphy, Constance; Nilsson, Carol; Ekman, Rolf; Department of Neurochemistry, University of Goteborg, Molndal, Sweden Fully Stable-Isotope Labeled Proteins: New Techniques for Production and PK/PD Studies Using CRIMS; *Osbom, Blaire L.; Abramson, Fred P.; George Washington University Using high- and low-energy CID MS/MS data to identify and characterize an unnatural amino acid; *Papayannopoulos, Ioannis A.; Biogen Inc., Cambridge, MA Structure elucidation of glutathione and related thiols by FAB, ESI and NICI mass spectrometry; *Ramanathan, Ragulan; Byun, Jaeman; Hsu, Fong; Gross, Michael; Cao, Kai; Cavalieri, Ercole; Washington University, Department of Chemistry, St. Louis, MO 63 130 Electrospray Tandem MS for Amino Acid Sequence Determination of Antineoplastic Peptides.; *Roboz, John; Wang, Tsonghui; Ma, Long Hua; The Mount Sinai School of Medicine, New York, NY 10029 A Study of Side-chain Involvement in CAD of tris(TrimethoxyphenyI)phosphonium-Derivatized Peptides; *Roth, Kenneth; Huang, Z.-H.; Watson, J. Throck; Michigan State University, East Lansing, MI 48824 Characterization of a hirudin beta-aspartyl isoform by low energy CID; *Schindler, P.; MYller, D.; Grossenbacher, H.; MSrki, W.; Richter, W. J.; Central Research Services Ciba-Geigy Ltd., CH-4002 Base1 HPLC-ESIMS in the quantitation of endothelins in cell culture medium and organ tissue; Schneider, Klaus; Van Leeuwen, Stefan; Peralta, Carmen; Canosa, Daniel; Abian, Joaquin; *Gelpi, Emilio; Instituto de Investigaciones Biomedicas. IIBB-CSIC, Barcelona
PRELIMINARY
TPL TPL TPL
407
PROGRAM
The observation of d-type ions during the low energy CID of protonated peptides; *Summerfield, Scott G.; Cox, Kathleeen A.; Gaskell, Simon J.; Michael Barber Centre for Mass Spectrometry, UMIST, Manchester, UK Structural characterization of the Dioclea drandiflora seed lectin using MALDI-MS, LC-MS and MS-MS; *Tang, Xuejun; Swamy, Bale M.; Brewer, C. Fred; Albert Einstein College of Medicine Identification of proteolytic fragments of peptide hormones by HPLC-ESI-MS and HPLC-ESI-MS-MS; *Treston, Anthony; **Snider, Richard; Nylen, Eric; Kelley, Michael; Becker, Kenneth; BPRB, National Cancer Institute, Rockville MD 20850-3300
TPL TPL TPL TPL
Characterization end quantification of opioid peptide analogs in sheep plasma by capillary LC/MS/MS; l Tseng, JihLie; Grigoriants, U.; Yan, Lin; Desiderio, D. M.; Deptments of Neurology and Biochemistry, University of Tenessee, Memphis Novel Peptide Dissociation: Gas Phase Intramolecular Rearrangement of Internal Amino Acid Residues; *Vachet, Richard W.; Bishop, Barney M.; Erickson, Bruce W.; Glish, Gary L.; University of North Carolina, Chapel Hill MS-MS characterization of the bradykinin peptide fragments RPP, RPPG and RPPGF.; l Vrbanac, James; Pharmacia & Upjohn, Inc., Kalamazoo, Michigan Surface-Induced Dissociation of Disullide-Containing Peptides; + Zhong, Wenqing; Wysocki , Vicki; Virginia Commonwealth University
WEDNESDAY
POSTERS
ION SOURCE AND MS INSTRUMENTATION Abstracts are arranged alphabetically byfirst author WPA WPA WPA
WPA WPA WPA WPA
WPA WPA WPA WPA WPA WPA WPA WPA WPA WPA
Time-of-Flight Mass Spectrometer System as a Detector for High Speed Gas Chromatography; *Artaev, Viatcheslav B.; Parry, Ritchard; Phinney, Mary Jane; Mitchell, Joel; LECO Corporation, St. Joseph Automated recording of MALDI MS and high energy CID MS/MS spectra on a tandem magnetic sector-TO& *Bateman, R. H.; Davis, T.; Green, M. R.; Kingston, R. G.; VG Organic, Manchester, M23 9LZ, UK Automatic recording of LC-MS & LC-MS-MS spectra on a tandem magnetic sector-TOF with magnet bypass.; Bateman, R. H.; Davis, T.; Green, M. R.; Ordsmith, N. H. R.; Pugh, D. J.; l Woolfitt, A. R.; VG Organic, Manchester, M23 9LZ, UK A New Generation MALDI TOF Tandem Mass Spectrometer; *Brinkmalm, Gunnar; Westman, Ann; Gafken, Phil; Barofsky, Douglas F.; Dept. Ag. Chem., Oregon State Univ., 1007 ALS, Corvallis, OR 97331-7301 Convergence of Spatially Dispersed Ion Beams from Ion Mirrors; l Constantopoulos, Terri L.; Erickson, Tina A.; Ji, Qinchung; Enke, Christie G.; University of New Mexico, Albuquerque, NM 87 I3 I Tandem TOF Mass Spectrometry: Applications to Fullerenes and Metal-Phthalocyanines.; *Cordero, M.M.; Comish, T.J.; Cotter, R.J.; Pharmacology, Johns Hopkins University Medical School, Baltimore MD A High Speed, High Voltage Analog Switch with Precise Timing Control for An Ion Trap-TOF MS; *Davenport, Michael R.; Holland, John F. ; Ji, Qinchung; Enke, Christie G.; Dept. of Chemistry, University of New Mexico, Albuquerque, NM A Theoretical and Practical Description of an Interleaved-Comb Ion Deflection Gate; *Erickson, Tina; Beussman, Douglas; Enke, Christie; University of New Mexico, Albuquerque Ion Isolation and Kinetic Energy Analysis in TOF Mass Spectrometry using a Two-section EPG; *Hanson, Curtiss D.; Adams, Nathan; Page, Jason; Just, Craig; University of Northern Iowa A Proposed Two Dimensional QuadrupolelElectrostatic Ion Trap Time-of-Flight Mass Spectrometer; *Ijames, Carl F.; National Institute of Mental Health, Bethesda Time-of-Flight Mass Spectrometry Analysis of Trapped Ions Generated by Electron Impact Ionization; *Ji, Qinchung; Holland, John F.; Davenport, Michael R.; Enke , Christie G.; Department of Chemistry, University of New Mexico A Transmission Geometry Probe for MALDI; *Lennon, III, John D.; Glish, Gary L.; University of North Carolina at Chapel Hill, Chapel Hill MS/MS of all precursor ions in one shot and MS’ capability by 2-D /3-D DEF-TOF; *Linden, H. Bernhard; Barnberg, Michael; Linden ChroMasSpec GmbH, Auf dem Berge 25, D-28844 Leeste, Germany Magnetic sector/time-of-flight combination for tandem analysis of MALDI ions using high-energy CID; *Raptakis, Emmanuel N.; Makarov, Alexander A.; Colbum, Alex W.; Derrick, Peter J.; University of Warwick High Resolution Reflectron Time-of-Flight Mass Spectrometer; *Reents, William; AT&T Bell Laboratories A new tandem quadrupole mass filter and othogonal acceleration TOF MS/MS configuration.; Bateman, R. H.; Bordoli, R. S.; Gilbert, A. J.; *Hoyes, J. B.; **Morris, H. R.; VG Organic, Manchester, M23 9LZ, UK Mass Resolution Improvement in MALDI-TOF Mass Spectrometry by Pulsed Ion Extraction; Zhang, Wenzhu ; l Niu , Shufang ; Chait, Brian T. ; The Rockefeller University, 1230 York Avenue, New York, New York 10021
FUNDAMENTAL STUDIES Abstracts are arranged alphabetically byfirst author WPB WPB
Beam-induced redox processes for the methylene blue/thioglycerol system in LSIMS.; *Allard, Martine; Bertrand, Michel, J.; University of Montreal, Montreal Determination of proton affinities by comparison of the abundances of ions formed under FAB; *Amado, Francisco M. L.; Santana-Marques, M. Gra a 0.; Ferrer- Correia, A. J. V.; Department of Chemistry, University of Aveiro, 3810 Aveiro, Portugal
408 v
44TH
ASMS
CONFERENCE
ON
MASS
SPECTROMETRY
* WPB WPB WPB WPB WPB WPB WPB WPB WPB WPB WPB WPB WPB WPB WPB WPB WPB WPB
Proton Affinities of MALDI Matrices; Burton, Richard D.; Watson, Clifford H.; Eyler, John R.; Lang, G. Lisa; Avery, Marcella Y.; *Powell, David H.; University of Florida, Gainesville, FL Conditions in favor of a linear dependence of annlyte ion signals on concentration in FAB MS; Klesper, Gtinter; Ptltzold? Sabine; Mertens, Christian; *RUllgen, Franz W.; Inst. of Physical Chemistry. University of Bonn Secondary ions and electrons in MALDI: Desorption and Detection, . *Knochenmuss, Richard; Dubois, Fr d ric; Zenobi, Renato; LOC, ETH ZYrich, ZYrich Switzerland Study of the processes of cryobiological interest by means of low temperature FAB mass spectrometry; *Kosevich, Marina ; Shelkovsky, Vadim; Boryak, Oleg; Institute for Low Temperature Physics and Engineering NAS Ukraine Laser-stimulated Matrix to Analyte Proton Transfer in Clusters; *Land, C. Mark; Kinsel, Gary R.; Dept. of Chemistry, The University of Texas at Arlington, Arlington, TX Studies of MALDI Matrix Proton Aftlnities by FT-ICRMS; *Li, Nan; Kinsel, Gary R.; Dept. of Chemistry, The University of Texas at Arlington, Arlington, TX . Study of the Behavior of a Series of Quaternary Ammonium Bromides under Positive and Negative LSIMS; l Marcotte, I.; Paul, G. J. C.; Anastassopoulou, J.; Bertrand, M. J.; University of Montreal, Montreal Factors Influencing the Clustering of Quaternary Ammonium Bromides in LSIMS; *Marcotte, 1.; Paul, G. J. C.; Anastassopoulou, J.; Bertrand, M. J.; University of Montreal, Montreal Primary Ion Dosimetry; l McMahon, John M.; McCandlish, Carl A.; Todd, Peter J.; Oak Ridge National Laboratory, Oak Ridge, Tennessee Cluster and Cluster Ion Formation from Organic Molecules Investigated by Multiphoton Ionization; Meffert, Anja; *Moritz, Fritz; Schied, Thomas; Grotemeyer, Jtlrgen; Institut fur Physikalische Chemie, Universittit Wthzburg An Investigation of the Ionization Mechanism in LSIMS for Cis-Stilbene Oxide; *Obarewicz, Stephan; **Paul, Gary J. C.; Bertrand, Michel J.; University of Montreal, Montreal. Formation of hydrate clusters under low temperature fast atom bombardment conditions; *Shelkovsky, Vadim; Kosevich, Marina; Boryak, Oleg; Stepanov, Igor; Institute for Low Temperature Physcis and Engineering NAS Ukraine Ion Yields from Matrix Surface Bombarded with 6 keV Xe, Ar, He, Air, and Isobutane Beams; *Takayarna, Mitsuo; Pharm. Sci., Toho Univ., 2-2-l Miyarna, Funabashi, Chiba 274, Japan Factors Influencing Nucleic Acid Analysis in MALDI:Fragmentation, Positive-Ion, and Mixture Analyss; *Tang, Wei; Zhu, Lin; Nelson, Christine; Smith, Lloyd; Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53706 Matrix Properties derived from the LSIMS Spectra of the Pure Matrices and Surface Tension Effects; *Theberge, Roger; Paul, Gary; Bertrand, Michel; Regional Center for Mass spectrometry, Montreal Coincidence TOF-MS: An Alternative to MS/MS for Multi-Component Sample Analysis; *Van Stipdonk, Mike; English, Robert; Schweikert, Emile; Department of Chemistry, Texas A&M University, College Station, Texas Metal-Binding Properties of a New Hexahomotriazacalix[3jarene by Electrospray-MS/MS; *Znamirovschi, Calin; Wu, Si; Hampton, Philip; Enke, Christie; Department of Chemistry, University of New Mexico, Albuquerque, NM 87 I3 I Contribution of chunk ejection to molecular ion formation in PDMS and SIMS; *Zubarev, Roman; Demirev, Plamen; HtEkansson, Per; Abeywama, Udaya; Sundqvist, Bo U. R.; Uppsala university, Sweden
ISOTOPE RATIOS, INORGANIC & ELEMENTAL Abstracts are arranged alphabetically byfirst author WPC WPC WPC WPC WPC WPC WPC WPC WPC WPC WPC WPC
ANALYSIS
Reduced Space Charge Effects in ICP/MS by Selective Elimination of Argon Matrix Ions; *Barinaga, Charles; Eiden, Gregory; Koppenaal, David; Pacific Northwest National Laboratory* Organometallic Speciation and Elemental Quantification Using Gas Chromatography/Mass Spectrometry; *Barshick, Christopher, M.; Lake, Derek, A.; Barshick, Stacy-Ann; Mohill, Matthew, L.; Britt, Phillip, F.; Oak Ridge National Laboratory Determination of trace elements in polysilicates by ID-ICP-MS with USN/membrane desolvation; *Bonchin-Cleland, Sandra; Olivares, Jose; Los Alamos National Laboratory, Los Alamos NM Inorganic Composition Analysis of Coal Surface with High Performance Secondary Ion MS; *Brozolo, Fillippo ; Liang, Handong; Re, Deyi; Mao, Helin; China University of Mining & Technology Preliminary Figures of Merit of a Plasma Source Mass Spectrograph; *Burgoyne, Thomas; Hieftje, Gary; Hites, Ronald; Indiana University, Bloomington, IN 47405 Tandem Mass Spectrometry of Polyruthenium Clusters using a Hybrid Sector/Orthogonal Acceleration TOF; *Curtis, Jonathan M.; Ghan, Kenneth H.N.; **Blenkiron, Peter; Catty, Arthur J.; Institute for Marine Biosciences, N.R.C., Halifax, Nova Scotia, Canada High Resolution and High Abundance Sensitivity Quadrupole ICP-MS; *Douglas, Don; Ying, Ji-Feng; University of British Columbia Design and properties of a laser ablation/ICP-MS for bulk analysis and geological applications; Douthitt, Chuck; Greb, Ulrich; Hamester, Meike; Rottrnann, Lothar; *Schroeder, Ernst; Finnigan MAT GmbH, Barkhausenstr.2, D-28197 Bremen, Germany. Determination of elements of pharmaceutical interest in biological samples of human origin by ICP-MS; *Dr. Michaelis, Karl; Dr. S&mid, Bernhard; Deseyve , Ewald; L.A.B. GmbH, Neu-Ulm, Germany Recent Improvements in a High-Efficiency Thermal Ionization Cavity Source for Mass Spectrometry; l Duan, Yixiang; Olivares, Jose; Los Alarnos National Laboratory, CST-9, MS J5 14, Los Alamos, NM, 87545. Selective elimination of argon ions in an inductively coupled plasma-ion trap mass spectrometer; *Eiden, Gregory; Barinaga, Charles; Koppenaal, David; Pacific Northwest National Laboratory* Elemental and Isotopic Analysis of Geological and Environmental Samples Using an ICP-ITMS; l Frum, C.I.; University of Nevada, Las Vegas /HRC , Las Vegas, NV 89154
PRELIMINARY
WPC
409
PROGRAM
On-Line
Kryton and Xenon Isotopic Analysis by Microwave
Plasma Ionization
Ion Trap MS; *Garrett, Aaron; Yixiang,
Duan;Olivares,Jose;Hemberger, Philip;LosAlamosNationalLaboratory,LosAlamos,NM WPC WPC WPC WPC WPC WPC WPC WPC WPC WPC WPC WPC
of resonant laser ablation - quadrupolc ion trap mass spectrometry; *Gill, C. G.; Garrett,A. W.; Earl,W. L. ; Hemberger, P.H. ; Nogar,N. S.; LosAlamosNationalLaboratory Mass Spectrometry of Heterobimetalloboranes and Related Species; *Gloeckner,Charles;**Barton, Lawrence;Monsanto Company,St.LouisMO Spiros,A. ; Heithmar,Edward, Assesment of Internal Standards for Arsenic in ICPMS; Hinners,Thomas, A.; l Pergantis, M. ; U.S. EnvironmentalProtectionAgency,LasVegas Observation of doubly charged mercury cluster ions, n=l-10 by using secondary ion mass spectrometry; *Hiroyuki, Ito; Toshio,Ichihara;Itsuo,Katakuse;Tot-u,Sakurai;Takekiyo,Matsuo;Dept.of Physics,Fat. of Science,OsakaUniv. Toyonaka,Osaka560,JAPAN Semi quantitative analysis of complex Polyoxometalate mixtures by means of electrospray ionisation.; *Jennings, Keith R.; Deery,MichaelJ.; Howarth,Oliver W.; Department of Chemistry,Universityof Warwick,Coventry,CV4 7AL. U.K. Measurements of Nickel-63 and Nickel-59 by AMS for Biomedical Studies; **Jones,Patrick;l McAninch, Jeffrey; Turteltaub,Ken;Hainsworth,Laura;Marchetti,Alfredo; Straume, Torr; Vogel,John;LawrenceLivermoreNational Laboratory,Livermore,CA A Transportable Actinide Mass Spectrometer (TAMS) System.; *Kahr, Michael;Olivares,Jose;Abney, Kent; LosAlamos NationalLaboratory,LosAlamos Elemental Analysis Using an Electrospray Ionization Source Coupled with an FT-ICR Mass Spectrometer; l Milgram, Eric; Goodner,Kevin; Watson,Clifford; Eyler, John;Department of Chemistry,Universityof Florida,Gainesville,FL Real-Time Monitoring of Plasma Particles; l Reents,William;Daugherty,John;AT&T Bell Laboratories Isotope ratio mass spectrometry using the chemical reaction interface with CC and HPLC introduction; *Teffera, Yohannes;Kusmierz,Josef;Abramson,Fred;GeorgeWashington University,WashingtonDC Probing Silicon Substitution in Aluminum Phosphate Molecular Sieves by TOF-MS.; *van Heimburg,Shera; Van Stipdonk,Mike; Schweikert,Emile;Department of Chemistry,TexasA&M University,CollegeStation,Texas Recent results on the three-aperture gas dynamic vacuum interface for ICP-mass spectrometry; *Ying, Ji-Feng; Douglas,Don; Dept.of Chemistry,Univ. of BritishColumbia,Vancouver,BC Advances & applications
ENVIRONMENTAL
ANALYSIS
Abstracts are arranged alphabetically byjirst author WPD
Analysis of 23 Triazine
Herbicides
by Ion Trap CC/MS/MS;
*Abraham,Vincy M.; Lynn, Jr., BertC.; MississippiState
University WPD WPD WPD WPD WPD WPD WPD WPD WPD WPD WPD WPD WPD WPD WPD
Organic Vapor Using SPME/GC-MS; *Alcaraz,Armando; Haas,Jeffery; Whipple,Richard;Grant,Patrick;Andresen,Brian;LawrenceLivermoreNationalLaboratory,LivermoreCA 94550 Determination of PAHs in Water Without Extraction Using LCMS; *Canty,John;Bach,Stephan;Streeper,Robert;The Universityof Texasat SanAntonio Enhanced Performance of a Micro-Flow Rate Particle Beam Interface in the Analysis of Explosives; *Cappiello,Achille; Famiglini, Giorgio;Berloni,Arnaldo;Istitutodi ScienzeChimiche,Universitadi Urbino,Urbino,Italy Use of Mass Spectrometry Coupled with a Direct Insertion Probe to Screen PAH Contaminated Soils; Check,Catherine; *Bach,Stephan;TheUniversityof Texasat SanAntonio Grosshans, Peter; Molybdenum Ion Trap for Analysis of Organochloride Pesticides; *Chen,Ruidan;PaIermo,Stephen; HitachiInstruments, Inc., 3100N. First St.,SanJose,CA 95134,USA APCI/MS/MS Method for the Determination of Trace Levels of Sulfonylurea Herbicides in Soil and Water; *Demers, Roger;Mendonca,Mark; Fenwick,John;Matassa, Luca;NOVAMANN International,Toronto,Ontario,CANADA Identification of Trace Compounds in Soil Using CC/MS in Conjunction with GC/AED Techniques; *Drexler,Dieter; Jordan,Jeannine;Wemess, Stephen;McGown,Steven;BASF Corporation,Research TrianglePark LC-MS/MS Identification and Analysis of a Major Human Urinary Metabolite of Metolachlor; *Driskell,William;Hill, Jr., Robert; Centersfor Disease ControlandPrevention,Atlanta,GA A Cold Trap-Membrane Introduction MS System for the Detection of VOCs in Water at Low ppt Levels; *Eberlin, MarcosN.; Mendes,Maria Anita; Pimpim,ReginaS.;Kotiaho,Tapio;Instituteof Chemistry,StateUniversityof Campinas Campinas, SPBraziI Determination of PCDD/F in Mixed Waste Compost from Small Static Piles; *Eitzer, BrianD.; Mattina,Mary Jane; Berger,William; TheConnecticutAgriculturalExperimentStation,NewHaven,CT MS analysis of agrochemicals and their metabolites using capillary LCIFAB; l Fujiwara,Hideji;Chott,Robert;Monsanto Company,St.Louis,Missouri Rapid Quantitative Determination of 2,4&Trinitrotoluene by Ion Mobility Spectrometry; +Garofolo,Fabio;Marziali, Fabio;Pagliuca,Angelo;Migliozzi, Vincenzo;Stama,Angelo;AMI-AeroportoPraticadi MareDASRS-RASAI-00040 Praticadi Mare(Rome)ITALY Analysis of PCBs, PAHs, and threat assessment standards by fast GC/HRMS and fast GC/TOFMS; *Grainger.James; Controland Green,Vaughn;Barr,JohnR.; Patterson, DonaldG., Jr.; **Holland,Jack,Gardner,Ben;Centersfor Disease Prevention A New Method for Determining Trihalomethane and Cyanogen Chloride Concentrations in Drinking Water; l Grifftn, Timothy; Bauer,Scott;Bauer,Janice;MIMS Technology,Inc. Solid-Phase Microextraction with Fast GC/MS for Benzne, Toluene and Xylenes Analysis; *Grimm,DeborahA.; **Grimm. CaseyC.; TulaneUniversity,NewOrleans A Rapid Screening Procedure for the Analysis of Radiolytic
410 .
44TH
ASMS
CONFERENCE
ON
MASS
SPECTROMETRY
* WPD WPD WPD
WPD WPD WPD WPD WPD WPD WPD WPD WPD WPD WPD
WPD WPD WPD
Detection of semivolatile organic compounds by trap and release membrane inlet mass spectrometry; *Lauritsen, Frants R.; Leth, Mads; Institute of Biochemistry, Odense University Analysis of pesticides and herbieides in drinking water using large volume injection CC-MS analysis; *Loftus, Neil; Hughes, Jonathan; VG MassLab, Crewe Road, Wythenshawe, Manchester, England. M23 9BE Real-time Field Analysis of Ground Water Samples using Membrane Introduction Mass Spectrometry-MIMS; *Markham, Dan; Gilberf Jeffery; West, Robert; Klecka, Gary; Barcelona, Michael; Major, Jr., C. Lee; The Dow Chemical Company, Midland, MI Analysis of volatile organic compounds from solid samples by MIMS; Mansikka, Timo; Ketola, Raimo; Ojala, Marja; l *Kotiaho, Tapio; *Kostiainen, Risto; VIT, Chemical Technology,P.O. Box 1401, FIN-02044 VTT, Finland Selective Detection of Coplanar PCB Congeners by Gas Chromatography Tandem Mass Spectrometry; l Miyares, Paul; Enke, Chris; University of New Mexico Reduction of Interfering Ion Production in PCB Analysis with N2 ECNCI; *Miyares, Paul ; Enke, Chris; University of New Mexico Rapid Determination of Thiourea in Waste Water by FIA-APCI-SRM-MS-MS; *Raffaelli, Andrea; Pucci, Sergio; Lazzaroni, Raffaello; Saivadori, Piero; Centro Studio CNR Macromolecole Stereordinate ed Otticamente Attive Upgrading the Perkin Elmer QMASS for Higher Sensitivity; Roy, Laura; Graves, Peter; *Hamerly, Thomas; Heller, Steve; Detector Technology, Inc., Sturbridge, MA Pesticide Residue Analysis; A Comparison Between GC/MS and GCIMSIMS; ‘Schachterle, Steve; Feigel, Carl; Varian Chromatography Systems, Walnut Creek GC-MS Characterisation of Products of Oxidation of Sulfur Heterocycles using Fenton’s Reagent; *Sokmen, Munevver; Allen, David W.; Clench, Malcolm R.; Hewson, Allan T.; Sheffield Hallam University, Sheffield, UK Use of a Direct Insertion Probe with Mass Spectrometry to Pre-Screen Soils for Fuel Contamination; *Stone, Earle; Rico, Catherine; Rodden, Elizabeth; Bach, Stephan; The University of Texas at San Antonio Analysis of Thermally Labile Pesticides by GC/MS and GClMSlMS with Temperature-programmed Injector.; *Vincze, Adam; Yinon, Jehuda; Weizmann Institute of Science, Rehovot, Israel On-line Postcolumn Photolysis LC-MS/MS Analysis of lsomeric Triazine Pesticides in Food Samples; l Volmer, Dietrich A.; Wilkes, Jon G.; National Center for Toxicological Research, Jefferson, AR Membrane Introduction Mass Spectrometry for Monitoring of Aromatic Compounds in Exhaust Gases; *Waite, Andreas; Matz, Gerhard; Muenchmeyer, Wolf; Gottfried, Kibelka; Technical University Hamburg-Harburg, Hamburg, Germany Investigating Arsine Generating Reactions by using Deuterium Labeled Reagents and Mass Spectrometry; *Winnik, Witold; Pergantis, Spiros, A.; Heithmar, Edward, M.; **Cullen, William, R.; U.S. Environmental Protection Agency, Las Vegas Real-Time Analysis of VOCs in Groundwater using In-Situ Sparge Direct Sampling Ion Trap MS *; *Wise, Marcus; Thompson, Cyril; **Davis, William; Oak Ridge National Laboratory, Oak Ridge, Tennessee Trace Analysis of Explosives in Water by CC/MS and CC/MS/MS with Temperature-programmed Injector.; *Yinon, Jehuda; Weizmann Institute of Science, Rehovot, Israel ORGANIC
ANALYSIS
- I
Abstracts are arranged alphabetically byjkst author WPE WPE WPE WPE WPE WPE WPE WPE WPE WPE WPE
SUPERSONIC MOLECULAR BEAM MASS SPECTROMETRY - THE OUEST FOR ULTIMATE PERFORMANE GC-MS AND FAST GC-MS; *Amirav, Aviv; Dagan, Shai; Tel Aviv University Trace Analysis in Complex Matrices: Problems and Practical Solutions; * Barshick, Stacy-Ann; Oak Ridge National Laboratory, Oak Ridge, TN LASER DESORPTION FAST CC-MS IN SUPERSONIC MOLECULAR BEAMS; l Dagan, Shai; Shahar, Tzvi; Amirav, Aviv; Tel Aviv University Fast Multidimensional MS3 Scans in a High-Transmission Pentaquadrupole Mass Spectrometer; l Eberlin, Marcos N.; Kascheres, Concetta; Lago, Claudimir L.; Juliano, Valmir F.; Gozzo, Fabio C.; Institute of Chemistry, State University of Campinas Campinas, SP Brazil A New Approach to Organic Mixture Analysis Using Time-of-Flight Mass Spectrometry; *English, Robert; Van Stipdonk, Mike; Schweikert, Emile; Department of Chemistry Analysis of Target Compounds in Highly Complex Matrices using Benchtop GCIMSIMS; l Fannin, Steven; Conoley, Meredith; Edwards, James; Finnigan, Austin TX 78728 Rapid Catalyst and Feedstock Screening by Molecular Beam Mass Spectrometry (MBMS); *French, Richard; Overly, Constance; Brace, Scott; Rejai, Bahman; Meglen, Robert; National Renewable Energy Laboratory, Golden, Colorado Identillcation of a Benzalkonium Chloride Contaminant on a Paper Surface by Simultaneous TG-IR-MS; *Lynch, Craig; McGuire, Jeffrey; Hercules Incorporated, Wilmington, DE Ion-Trap Analysis of Anthraquinone in a Complex Matrix by GC/MSlMS Resonant and Non-Resonant CID; *Mosi, Andrew; Cullen, William; Eigendorf, Guenter; University of British Columbia, Department of Chemistry High-energy collision-induced dissociation of homo-N-deoxynucleosides; *Rozenski, Jef; Hossain. Nalizal; Herdewijn, Piet; Rega Institute for Medical Research Analysis of Commercial Vanilla Extracts Utilizing Multidimensional GC/FTIR/MS; l Sasaki, Tania A.; Wilkins, Charles L.; University of California, Riverside
PRELIMINARY
PROGRAM
411
ORGANIC ANALYSIS - II
Abstracts are arranged alphabetically byjirst author WPF WPF
WPF WPF WPF WPF WPF WPF WPF WPF WPF WPF WPF
Studies of Sulfated Marine Toxins by MS and MS/MS Using a Hybrid Sector/Orthogonal Acceleration TOF; *Curtis, Jonathan M.; Hu, Tingmo; Wright, Jeffrey L.C.; Institute for Marine Biosciences, NRC, Halifax, Nova Scotia, Canada Generation of Metalloporphyrins in the source under Fast Atom Bombardment ; Domingues, Mx RosSrio M.; SantanaMarques, M. Gra a 0. ; *Amado, Francisco M. L.; Ferrer-Correia, A.J.V.; Department of Chemistry, University of Aveiro, 38 10 Aveiro, Portugal Comparison of LSIMS and ES1 for Measurement of Mass Spectra of Metal-Containing Compounds; *Geiger, Robert; Busch, Kenneth; Bartlett, Michael; School of Chemistry & Biochemistry, GA Inst. of Technology, Atlanta, GA Quantitation and confirmation of seven tetracyclines residues in kidney tissues by APcI LC/MS/MS; Kwok, David; *Alleyne, Carl; Chow, Pauline; Young, Larry; **Young, Man Sen; Mori, Brian; Health Protection Branch, Health Canada, Bumaby, B.C., Canada V5G 4P2 Mixed-Metal Cluster Ions in LSIMS Mass Spectra of Acetylacetonates; l Lemire, Sharon; Geiger, Robert; Downey, Nicolas; Busch, Kenneth; School of Chemistry & Biochemistry, Georgia Inst. Technology, Atlanta, GA A New Reference Compound for Fast Atom Bombardment High Resolution Mass Spectrometry; *Longfei, Jiang; Moini, Mehdi; University of Texas at Austin, Austin Sulfonium Salt Reactions with LSIMS Solvents Induced by Primary Beam Bombardment; *Melnyk, Michael; Busch, Kenneth; **Dunphy, Richard; Burinsky, David; School of Chemistry & Biochemistry, Georgia Inst. of Tech., Atlanta, GA Determination of Free Amino Acids and Vitamins by HPLC Particle Beam Mass Spectrometry; l Mesmer, Mantai; Satzger, R. Duane; Forensic Chemistry Center, USFDA, Cincinnati, OH Separation and Characterization of Metal Complexed Sulfonated Azo Dyes by Flow FAB MS; *Sanford, Howard; **Bardole, Heather; Freeman, Harold; North Carolina State University, Department of Chemistry, Raleigh, NC Soft Ionization MS of Chromanols Produces Radical Cation Molecular Ions; *Sharp, Thomas; Pfizer Central Research Matrix-Enhanced Secondary Ion Mass Spectrometry: A New Method for Molecular Analysis of Surfaces; *Wu, Kuang Jen; Odom, Robert W. ; Charles Evans & Associates Redwood City, CA 94063 Structural Elucidation of Aporphine-Benzylisoquinoline Alkaloids by API Ionspray MS and MS/MS; *Wu, Wu-Nan; The R.W. Johnson Pharmaceutical Research Institute Liquid Ionization Mass Spectrometry for Reaction Study - Formaldehyde Oligomers in a Solution; Kaneko, Takeo; Yang, Peiming; Saito, Jun; *Tsuchiya, Masahiko; Yokohama National University, Tokiwadai, Hodogaya-ku, Yokohama Japan
POLYMERS, SURFACTANTS, PETROCHEMICALS
Abstracts are arranged alphabeticah’y byfirst author WPG WPG WPG WPG WPG WPG WPG
WPG WPG WPG WPG WPG WPG WPG WPG
Mass discrimination effects in an ion detector exemplified by MALDI mass spectrometry of polymers; *Axelsson, Jan; Scrivener, Elaine; Haddleton, David M.; Derrick, Peter J.; Department of Chemistry, University of Warwick, UK Measuring Cationization Effects on the MW Distribution of an Ethoxylated Polymer by ToF-SIMS; *Conelio-Clark, Paula A.; Hanton, Scott D.; Parees, David M.; Air Products & Chemicals, Inc., Allentown, PA I8 195 Nebulised Spray Deposition of Synthetic Polymer Samples for MALDI Analysis; *Cottrell, John S.; Dwyer, J. L.; Liu, X.; **Willis, James N.; Therm0 BioAnalysis Ltd., Hemel Hempstead, UK A study of cation attachment to polystrene by means of ES1 and MALDI.; *Decry , Michael ; Jennings, Keith ; Buzy, Armelle; Jasieczek, Christina ; Haddleton, David ; **Jackson, Tony ; Yates, Hilary ; Scrivens, Jim; University of Warwick Polymer Characterization using Radio Frequency Glow Discharge Mass Spectrometry; +DePalma, Jr., Patrick; Shick, Jr., Charles R.; Gibeau, Terri E.; Marcus, R. Kenneth; Clemson University Studies of the Cationization Behavior of Small Oligomers in the MALD/I Experiment; Goldschmidt, Robert; Xiong, Yansan; *Owens, Kevin G.; Hanton, Scott; Department of Chemistry, Drexel University, Philadelphia, PA 19104 Characterization of cyclic polyesters pure or in mixtures using ES1 and MALDI Mass Spectrometries; Guittard, Joelle; *Blais, Jean Claude; Bolbach, G rard; Brunot, Alain; Gannet, Florence; Tabet, Jean Claude; Universit Pierre et Marie Curie Paris Mass Analysis of a Large, Anionic Spherical Dendritic Macromolecule; *Haney, Carol; Gorman, Christopher; Parkhurst, Brandon; Chen, Kang-yi; **Martin, Roy; North Carolina State University, Department of Chemistry, Raleigh, NC Improved Detection of Polydispersed Polymers by Combining MALDI-TOF MS with SEC Fractionation; *Hoberg, Anne-Mette; Haddleton, David M.; Scrivens, Jim H.; Derrick, Peter J.; University of Warwick Caracterization of Ethylene and Propylene Oxide Copolymers; *Lacey, M.P.; Keough, T.; Pan, Y.; Armstrong, M.P.; Fritz, M.D.; The Procter and Gamble Co. Desorption Behavior and Distributions of Fluorinated Polymers In MALDI and Electrospray Ionization; *Latourte, Laurence; **Cole, Richard; Blais, Jean Claude; Bolbach, G rard; Brunot, Alain; Gannet, Florence; Tabef Jean Claude; Universit Pierre et Marie Curie, CNRS EP 103, Paris Time-of-Flight Secondary Ion Mass Spectrometry of Substituted Polystyrenes; *Lee, Yeonhee, K; Han, Seunghee; Korea Institute of Science and Technology, Seoul The Effects of Sample Preparation and Delayed Extraction on the MALDI Analysis of Synthetic Polymers; *Mowat, Ian A.; Donovan, Robert J.; Monaghan, John M.; University of Kent, Canterbury, England, UK MALDI-TOF MS Study of Industrial Polymers; *Rozynov, Boris; Liukkonen, Robert; Sarpong. Martha; Aspen Research Corporation, 436 West County Road D, New Brighton, MN 55 I I2 Polymer Analysis by Time-Lag Focusing MALDI TOF MS; *Whittal, Randy; Schriemer, Dave; Li, Liang; Department of Chemistry, University of Alberta
412 .
44TH
ASMS
CONFERENCE
ON
MASS
SPECTROMETRY
-
WPG
MALDI-TOF
Analysis of Polyethylene Terephthalate
(PET) of Varying Structure;
*Yates,Hilary; Scrivens,Jim;
Jackson,Tony; **Decry, Michael;ICI Research andTechnologyCentre WPG
Sequencing Copolymers
using Thermal
Desorption-Photoionization
Mass Spectrometry;
l Zoner,David; Johnston,
Murray; Universityof Delaware, Newark,DE SEPARATION/MS TECHNIQUES - INSTRUMENTATION
Abstracts are arranged alphabetically byflrst author WPH WPH WPH WPH WPH WPH WPH WPH WPH WPH WPH WPH
Fast Capillary Electrophoresis Separations With Time-of-Flight Mass Detection: *Banks,J. Fred;Boyle, James; Dresch, Thomas~Gulcicek, Era
Abstracts are arranged alphabetically byfirst author WPI WPI WPI WPI WPI WPI WPI WPI WPI WPI WPI WPI WPI
Identification of vertebrate type steroid hormones in the shrimp P. japonicus by MS/MS and MS/MS/MS; Cardoso, Ana M.; Barros,CristinaM. F.; *Ferrer-Correia, A. J.; Cardoso, J. M. ; Cortez,A.; Carvalho,F.; BaIdaia,L.; Departamento deQuimica-Universidade deAveiro-3800Aveiro-Portugal ESIMS characterization of phosphatidylinositol phosphates; *Clay, Keith; MacMillan,Denise;NationalJewishCtr. ImmunologyandRespiratoryMedicine,Denver,CO Analysis of Cyclooxygenase and Lipoxygenase Metabolites of Arachidonic Acid by LCIMSIMS; *Duftin, Kevin; Margalit, Alon; Isakson,Peter;MonsantoCorporateResearch, MonsantoCompany,St.Louis,MO 63198 Nonenxymatic Formation of Biologically Active Eicosanoids During Lipid Peroxidation; *Hall, Lisa,M.; Murphy, Robert,C.; NationalJewishCenterfor ImmunologyandRespiratoryMedicine- Denver LCMSMS Analysis of Peanut Phospholipids; *Haney,Carol;Ruan,Minzi; Sanford,Howard;**Singleton,John;North CarolinaStateUniversity,Department of Chemistry,Raleigh,NC Studies on Acyl-Co-A with MALDI-TOF PSD and CID MS/MS; *Hsu,Fong-Fu;Gross,MichaelL.; Department of Chemistry,Washington University,St. Louis,MO 63130 Determination of Novel Indicators of Human Fecal Pollution in Water by APCI-LCIMS and ESI-LCIMS; *Kryak, David; de la Cruz,Armah;U.S. Environmental ProtectionAgency,Cincinnati Characterization of seed oils for potential technical use by HPLC, API mass spectrometry and MS/MS; *Pittenauer, Ernst,Aichinger,Thomas;deHueber,Karl; Bailer,Josef;FederalOffrceandResearch Centerfor Agriculture,A-1220Vienna, Austria Differentiation of Steroid Isomers by Controlled Fragmentation in APCI-MS; *Sjoberg,PerJ. R.; Markides,KarinE.; Dept.of Analytical Chemistry,UppsalaUniversity ES1 Mass Spectrometric Profiling of Bacterial Phospholipids: Effects of Environmental conditions.; *Sweetman, Gavain; Freestone, Primrose;Trinei, Morella;Toth, Istvan;Norris,Vie; MRC ToxicologyUnit, Leicester,UK Oil-degrading Bacterium Secretes a Novel Anionic Surfactant: Acyloxyacyiated Trehalose Trisaccharide; *Williams, ToddD.; Esch,Wynn-Steven;Morton, MarthaD.; Buller,ClarenceS.;TheUniversityof Kansas,LawrenceKS 66045 ESI-MS/MS Analysis of Oxonides of Polyunsaturated Fatty Acids in Phospholipids; Harrison,Kathleen;*Wheelan,Pat; Murphy, Robert;NationalJewishCenterfor ImmunologyandRespiratoryMedicine LClESIhIS and LClAPCDMS analysis of Triacylglycerols; Zanella,Isabelle;Flament., M.MagdeIeine;Girault,Sophie; *Becchi,Michel; CNRS-SCA-Laboratoire deSpectromtrie deMasse-BP 22-69390Vemaison-France
PRELIMINARY
413
PROGRAM
CLINICAL
AND BIOMEDICAL
MS
Abstracts are arranged alphabetically byfirst author WPJ WPJ WPJ WPJ WPJ WPJ WPJ WPJ WPJ WPJ WPJ WPJ WPJ WPJ WPJ WPJ WPJ WPJ WPJ WPJ
WPJ WPJ WPJ
WPJ WPJ WPJ WPJ WPJ
Determination of [13C]leucine enrichment in muscle proteins using Isotope Ratio Mass Spectrometry; l Balagopal, P.; Ford, G.C.; Nair, KS.; Mayo Clint Characterization of Heterogeneity in MHC Class II Peptides using MALDI; *Beeson, Michelle D.; Pohl, Jan; Sundstrom, J. Bruce; Jollow, Kim; Ansari, Aftab A.; Microchemical Facility, Winship Cancer Center, Emory University, Atlanta Structural Characterization of Human Renal Dialysate Protein by mPC-CEMWMS; *Benson, Linda M.; Tomlinson, Andy J.; Londowski, James M.; Kumar, Rajiv; Naylor, Stephen; Mayo Clinic Characterization of Acetaldehyde Modified N-Terminal Peptides of the Hemoglobin Beta Chain.; *Braun. Karen P.; Pavlovich, James G.; Jones , Danes R.; Peterson , Charles M.; Sansum Medical Research Foundation; Santa Barbara, CA Characterization of Glycated Hemoglobin by Electrospray Ionization Mass Spectrometry.; *Braun, Karen P.; Pavlovich, James G.; Goldstein, David; Little, Randie; England, Jack; Noffsinger, Jim K.; Peterson, Charles M.; Sansum Medical Research Foundation, Santa Barbara, CA Quantitative and Qualitative Analysis of Albumin in Human Serum Reference Materials; *Bunk, David; National Institute of Standards and Technology, Gaithersburg, MD Quantification of a New Leukotriene Antagonist (CGP 45715A) in Human Plasma Using ES1 LCIMSIMS; *Carlsen, Stephen; Hayes, Michael; Khemani, Lakshmi; Ciba Pharmaceuticals, Summit NJ Rapid Analysis of Basic Amino Acids by Tandem Mass Spectrometry, * l Chace, Donald; Hillman,Steven; Duke University Medical Center, MS Facility, Research Triangle Park, NC The Conversion of beta-carotene-d8 to retinol-d4 in Humans Using APCI-MS and GCIECNCI-MS; *Dolnikowski, Gregory; Tang, Guangwen; **Andrien, Bruce; Tufts University, Boston Occurence and Levels of Di- and Trihydroxy Fatty Acids in Generalized Peroxisomal Disorders; *Evans, James E.; Street, Jacqueline M.; Evans, Barbara A.; The E. K. Shriver Center for Mental Retardation, Waltham, MA Troponin Analysis by MALDI Mass Spectrometry; *Fitzgerald, Robert; Harris, Kenneth; Frankel, Wendy; Herold, David; VA Medical Center San Diego and University of California San Diego Analysis of the Haemophilus influenzae proteome using 2-D and tandem mass spectrometry; Hays, Lam G.; *Link, Andrew J.; Yates, III, John R.; Univerity of Washington, Seattle, WA The determination of glycated hemoglobin by mass spectrometry; Morris,‘Michael; *Jarvis, Stuart; Green, Brian; Roberts, Norman; VG Organic, Tudor Road, Altrincham, Cheshire WA14 5RZ, UK. Automated ES1 MS in Clinical Analysis of Variant Hemoglobins.; *Kim, John; Witkowska, H. Ewa; Lau, Bing-Chuen; **Green, Brian N.; Shackleton, Cedric H. L.; Children’s Hospital Oakland Research Institute, Oakland, CA Microdialysis and GClMS of NAA/NAAG in focal Epileptogenesis; l Lin, Shen-Nan ; Slopis, John; Willmore, James; Butler, Ian; Li, Li; Caprioli, Richard; University of Texas Medical School, Houston, Texas 77030 Interaction of nitric oxide with biological peptides; *Mathews, W. Rodney; Laskey, Rachel; Pharmacia & Upjohn, Kalamazoo Anatomical Features in Biologic Tissue Determined by Secondary Ion Mass Spectrometry; l McCandlish, Carl A.; McMahon, John M.; Todd, Peter J.; Oak Ridge National Laboratory, Oak Ridge, TN Detection of specific disorders in neonates by mass spectrometry; *Morris, Michael; **Chace, Donald; Hillman, Steven; VG Organic, Tudor Road, Altrincham, Cheshire WA14 5RZ, UK. Enhancing Sample Loading in CE-MS Using a Membrane Preconcentration-CE Cartridge (mPC-CE); +Naylor, Stephen; Benson, Linda M.; Tomlinson, Andy J.; Mayo Clinic, Rochester, MN 55905, USA Identification of Flavopiridol in Clinical Samples using Liquid Chromatography/Mass Spectrometry; *Phillips, Lawrence R.; Wolfe, Tracy L.; Hill, Kimberly; Stinson, Sherman F.; Laboratory of Pharmaceutical Chemistry, DTP, DCT, National Cancer Institute In Vivo Microdialysis and LCIESI-MS Studies on Kyotorphin-induced Met-enkephalin Release in Brain; *Prokai, Laszlo; **Roboz, John; Kim, Ho-Seung; Ma, L.; Wang, T.; Center for Drug Discovery, University of Florida, Gainesville Diagnosis of Sulfur Amino Acids Metabolic Abnormalities by Automated Electrospray MS/MS; *Rashed, Mohamed; Ozand, Pinar; Al-Shahwan, Saad; Al-Saban, Essam; Sakati, Nadia; Joshi, Surendra; Jishi, Emtethal; King Faisal Specialist Hospital and Research Centre Diagnosis of Metabolic Disorders Using Automated ESI-MS/MS and Computer-Assisted Data Analysis; *Rashed, Mohamed; Bucknall, Martin; Little, Douglas; Jacob, Minnie; Al-Amoudi, Mohamed; Awad, Amin; Oxand, Pinar; King Faisal Specialist Hospital and Research Centre Mapping of Plasma Proteins using Multi-DimensionaFHPLC-ESIMS or MALDDMS; Seta, Kazoo; *Isobe, Toshiaki; Yasukawa, Keiko; **Kanai, Michiko; Ikezawa, Hidenori; Yamaguchi, Mihoko; Okuyama, Tsuneo; Biochemistry, Tokyo Metropolitan University Analysis of a New Transthyretin Variant Associated with Type I Familial Amyloidotic Polyneuropathy; *Takahashi, Toshie; **Kasama, Takeshi; Baba, Satoshi; Shimizu, Takao; Dep. Biochem., Fat. Med., University of Tokyo, Tokyo A General Strategy for Isolating and Sequencing MHC Class I Peptides; *Tomlinson, Andy J.; Gallagher, Richard; Derrick, Peter; Butcher, Geoffrey; Powis, Simon; Naylor, Stephen; Mayo Clinic, Rochester, MN 55905, USA Thermal in Situ Methylation of Biomolecules for Mass Spectral Analysis; *Voorhees, Kent; Basile, France; Abbas-Hawks, Christy; Hendricker, Alan; Beverly, Michael; Department of Chemistry, Colorado School of Mines, Golden, CO 80401 Drug screening of amines in biological matrices with on-line CII/ESI/MS/MS; *Wheeler, Kevin; Mylchreest, Iain; **Lilley, Kim; Wheat, Thomas; Finnigan Corp., subsidiary of ThermoQuest Corp., San Jose, California
414
44TH
ASMS
CONFERENCE
ON
MASS
SPECI-ROMETRY
TOXICOLOGY
Abstracts are arranged a$habeticah’y byf?rst author WPK
Determination
of EDTA in forensic samples by capillary CC-MS and CC-MS/MS;
*Ballard,Kevin; Orkiszewski,Ralph;
**Taylor, Marc; Ragle,Larry; Baylor Collegeof Medicine,Houston,TX WPK WPK WPK WPK WPK WPK WPK WPK WPK WPK WPK WPK WPK WPK WPK WPK WPK WPK WPK WPK WPK
resistance: Novel elimination mechanism chnrncterixed by LC-MS and LC-MS-MS; *Bateman,Kevin; Yang, Keqian;Thibault,Pierre;White,Robert;Vining, Leo;Dalhousie University,Halifax, NS, Canada Membrane PC-CE-MS Analysis of 3-Phenylamino-l&Propanediol (PAP) Metabolites; *Benson,LindaM.; Mayeno, Arthur N.; **Wells,David A.; Tomlinson, Andy J.; Gleich,GeraldJ.; Naylor, Stephen;Mayo Clinic, Rochester, MN 55905, USA Fast Analysis of Anabolic Steroids in,Urine Samples by ES1 Tandem Mass Spectrometry; *Chang,Yoon-Seek;Chung, Bong-Chul;Jang,Jung-Suk;Yoo. Jong-Shin;HanyangUniversity,Ansan,Korea Determination of Incurred Clenbuterol Residues in Bovine Liver Using LC-APCYMS and MS/MS; *Churchwell,M.I.; Holder,C.L.; Preece,S.W.; Bajic,S.;Doerge,D.R.; NationalCenterfor ToxicologicalResearch, Jefferson,AR Multiresidue Conilrmation of Gentian Violet and Leucogentian Violet in Catfish Using LC-APCDMS; *Doerge,D.R.; Churchwell,MI.; Rushing,L.G.; Bajic, S.;NationalCenterfor ToxicologicalResearch, Jefferson,AR Quantification of Heterocyclic Amine Carcinogens in Cooked Meats Using LC-APcI./MS/MS; *Doerge,DanielR.; Holder,C. Lee;l *Preece,Steve;NationalCenterfor ToxicologicalResearch, Jefferson,AR 72079 Analysis of Heterocyclic Amine Metabolites by uLC-ESI/MS/MS; +Eades, Donald;**Malfatti, Michael;Felton,James; Chemistry& MaterialsScience,LLNL Identification and Quantification of Spinosad Metabolites in the Fischer 344 Rat using LCIMS.; *Gilbert, Jeffrey; Markham,Dan;Domoradzki,Jean;Mendrala,Alan; DowElanco,Indianapolis, IN Confirmatory analysis of parent spectinomycin residue in bovine tissues by HPLC/APCI/MS/MS; *Homish,Rex;Wiest, John;Pharmacia & Upjohn,Inc., KalamazooMI Studies on Glutathione-Dependent Bioactivation in Rats of Sevoflurane Degradate “Compound A”; l Jin, Lixia; Davis, MargaretR.; Kharasch,EvanD.; Doss,GeorgeA. ; **Baillie, ThomasA.; Dept.of MedicinalChemistry,Universityof Washington,Seattle,WA 98195 Free Radicals in Tamoxifen Metabolism: Study by “On-line” HPLC-Electrospray MS; *Jones,Russell;Lamb,John; White, Ian; Lim, ChangKee;Smith,Lewis;MRCToxicologyUnit, LeicesterUK Characterization of Fumonisin Mycotoxins by LClESI/MSn using a Benchtep Quadrupole Ion Trap; *Josephs, Jonathan;FinniganMAT, SanJoseCA APCI MS and MS/MS for the Structural Analysis of Tocopherols and Their Oxidation Products (1); *McClure, Thomas,D. ; **LiebIer,Daniel,C. ; SWEnvironmental HealthSciences Center,Univeristyof Arizona, Tucson Mass Spectrometric Investigations of QuinonelAmino Acid Interactions; *Oberth,C.H.; Jones, A.D.; Facility for AdvancedInstrumentation, Universityof California,Davis Tandem mass spectrometry as a tool in determining possible causes of disease; l Schurz,HelenH.; Hill, RobertH.; Etzel, Ruth;Philen,Rossanne; Posada, Manuel;Neddham, Larry; Centersfor Disease Control,Atlanta, Georgia Applications of ESI-LC-MS/MS to the analysis of beterocyclic aromatic amines in human urine.; *Stillwell, W. G.; Kidd, L. R; Wishnok,J. S.; l *Yu, M. C.; Ross,R. K.; Henderson, B. E.; Skipper,P.L.; Tannenbaum, S.R.; Massachusetts Instituteof Technology,Cambridge, MA 02139 Comparative LC/MS/MS studies of the metabolism of 4ene VPA and its fluoro-analog in rat hepatocytes; *Tang,Wei; Jurima-Romet, Malle; Abbott, Frank;Universityof BritishColumbia,Vancouver,BC, Canada Rapid Identification and Quantitation of Clenbuterol in Bovine Retinal Tissue by LC/ESI/MS/MS; *Tomlinson,John; Flurer,Rick; Lin, Lorrie;Satzger,R. Duane;ForensicChemistryCenter,U.S. FoodandDrugAdministrationCincinnati Quantification of Drugs of Abuse by SPE and CC/MS using Microliter-Amounts of Serum; *Weinmann,Wolfgang; Bohn,Christa;Instituteof LegalMedicine,Albertstr.9, D 79104Freiburg,Germany Ultrasensitive Method for the Direct Determination of Vinyl Chloride in Mainstream Cigarette Smoke; *White, Earl; Sequeria,Anna; R.J.ReynoldsTobaccoCompany Contaminants of L-tryptophan Associated with the Onset of EMS Characterized by LC-APCI-MS/MS; *Williamson, BrianL.; Benson,LindaM.; Tomlinson,Andy J.; Mayeno,Arthur N.; Gleich,GeraldJ.; Naylor, Stephen;Mayo Clinic, Rochester, MN 55905,USA LASER DESORPTION - APPLICATIONS Antibiotic
Abstracts are arranged alphabetically by first author WPL WPL WPL WPL WPL
of Peptide Nucleic Acid Synthesis Products Using MALDI-TOFIMS; *Butler, John;Jiang-Baucom, Ping; Huang,Meng;Belgrader,Phillip;Girard,James; NationalInstituteof Standards andTechnology,Gaithersburg, MD DNA-metal interactions studied using MALDUTOF mass spectrometry; Christian,Noah;Houston,Christopher; *Reilly, James; Departmentof Chemistry,IndianaUniversity,Bloomington,Indiana Mass Spectrometry of Proteins Directly from SDS Gels; *Cohen,StevenL.; Chait,BrianT.; TheRockefellerUniversity, NewYork City, NY Analysis of Canadian Wheat Varieties by Matrix Assisted Laser Desorption TOF-MS; *Dworschak,Ragnar;Ens, Werner;Standing,Ken; **Stevenson,Susan;Hatcher,David, Preston,Ken;Universityof Manitoba,Winnipeg,Manitoba, R3T 2N2, Canada Symmetry of Multimeric Proteins Determined by MALDI MS; *Farmer,Terry; Caprioli,Richard;Universityof Texas MedicalSchool,Houston,Texas77030 Evaluation
PRELIMINARY
WPL WPL WPL WPL WPL WPL WPL WPL WPL WPL WPL WPL WPL WPL WPL WPL WPL WPL WPL WPL WPL WPL WPL WPL WPL WPL
415
PROGRAM
Peptide Profiling with MALDI-TOF MS of Isolated Neurons from Marine Invertebrates; *Garden, Rebecca; Moroz, Leonid; Moroz, Tatiana; Sweedler, Jonathan; Department of Chemistry, University of Illinois, Urbana Sequencing of nucleic acids by MALDI-MS; *Hahner, Stephanie; Kirpekar, Finn; Nordhoff, Eckhard; Krisiansen, Karsten; Roepstorff, Peter; Hillenkamp, Franz; Institute for Med. Physics and Biophysics, University of Muenster, Germany MALDI-PSD TOF MS Characterization of Oligosaccharides Prepared by Enzyme-Assisted Synthesis; l Helin, Jari; Costello, Catherine; **Renkonen, Ossi; Boston Univ. School of Medicine, Boston, MA Ultraviolet MALDETOF MS and PSD Structural Determinations of Spore Cortex Muropeptides; l Helin, Jari; Costello, Catherine; **Popham, David; Setlow, Peter; Boston Univ. School of Medicine, Boston, MA Rapid Identification of Intact Whole Bacteria Based on Spectral Patterns Using MALDIfTOF MS; *Holland, Ricky D.; Wilkes, Jon G.; Raffii, Fatemeh; Persons, Cecil C.; Voorhees, Kent, J.; Lay, Jr., Jackson 0.; National Center for Toxicological Research, Jefferson, AR, 72079 Analysis of theCrude Spider Venom Extracts using MALDI-SectorTandem Mass Spectrometry; *Itagaki, Yasuhuro; Fujita, Tsuyoshi; Naoki, Hideo; Nakajima, Terumi; Suntory Institute for Bioorganic Research Characterization of PNA by MALDI-TOF Mass Spectrometry; *Jiang-Baucom, Ping; **Butler, John; Wheeler, Nea; Belgrader, Phillip; Girard, James; Department of Chemistry, The American University, Washington, DC 20016 Sequencing of the Responce Regulator Protein SPOOF by MALDI-PSD; *Jones, William; Caldwell, Gary; Masucci, John; The R.W. Johnson Pharmaceutical Research Institute, Spring House, PA. I9477 Analysis of Molybdopterines by MALDI; l Lecchi, Paolo; Pannell, Lewis; Gladishev, Vadim; Laboratory of Analytical Chemistry, NIDDK, NIH, Bethesda, MD 20892-0805 Fragmentation Mechanisms of N-Terminal Charge-Localized Peptide Derivatives; *Liao, Pao Chi; Allison, John; Huang, Z.H.; Gage, Douglas; Roth, Kenneth; Watson, J.T.; Michigan State University, East Lansing High Resolution Mass Spectrometry of Oligonucleotides with an External Ion Source FTMS; *McIver Jr., Robert T.; **Li, Yunzhi; Hunter, Richard L.; Department of Chemistry, University of California, Irvine, CA 92717 Structural Analysis of the HIV-l Protein Nef by Mass Spectrometry; * Mirza, Urooj A.; Lee, Chi-Hon; Kuriyan, John; Chait, Brian T.; The Rockefeller University , 1230 York Av., NewYork N.Y 10021 Proteinase specificities study by MALDI-TOF mass spectrometry ; l Moniatte, Marc; Si Tahar, Mustapha; Chignard, Michel; Van Dorsselaer, Alain; Laboratoire de Spectrometrie de masse Bio-Organique, ULP, Strasbourg *Packman, Len C; Dingley, David C; Humphrey, Paul; Department of MALDI Analysis of Synthetic Oligonucleotides; Biochemistry, University of Cambridge, Cambridge, CB2 IQW, UK Mass analysis of growth factors associated with proliferative diabetic retinopathy by MALDI - MS; *Perera, I. K.; Bagga, P.; Verma, D.; Dyer, P. E.; Department of Applied Physics, University of Hull, Hull HU6 7RX, England Detection of Noncovalent Complexes by MALDI TOF MS; *Pramanik, Birendra; Huang, Eric; Tsarbopoulos, Anthony; Girijavallabhan, V.M.; Ganguly, Ashit; Farmer, Terry; Caprioli, Richard; Schering-Plough Research Institute, Kenilworth, NJ 07033-0539 Identification of Bacterial Pathogens by Direct MALDI-MS Analysis of Cellular Proteins.; *Ross, Philip L.; Krishnamurthy, Thaiya; Biopolymer Facility, U. S. Army ERDEC, Aberdeen Proving Ground, MD. Rapid and Sensitive Analysis of Enzyme Inhibition by a MALDI Mass Tracer Method; *Schriemer, David C.; O’Callaghan, Kelly; Vederas, John; Li, Liang; University of Alberta, Edmonton, Alberta, Canada Stablizing Effects of Complex Formation in MALDI of Oligonucleotides; *Tang, Xiaodong; Vertes, Akos; Chemistry Department,The George Washington University,Washington D.C. 20052 Acceleration Voltages Needed for Observation of MALDI Ions from Surfaces of Interest to Biochemists; l Vestling, Martha; Johnston, Murray; Larsen, Barbara; University of Delaware, Newark, DE Searching for the biochemical markers for Alzheimer’s disease using immunoprecipitation/S; *Wang, Rong; The Rockefeller University Qualification and Validation of a MALDI-TOF Mass Spectrometer for cGMP Compliance; *Wellemans, Joelle; Spaltro, John; Seetharam, Ram; McEntire, John; Adams, Greg ; Microbiological Assocciates, Inc., Rockville, Maryland The role of mass spectrometry in large-scale DNA sequencing; l Williams, Peter; Chou, Chau-Wen; Dogruel, David; Arizona State University Comparing MHC Class I Peptide from Normal and Cancerous Murine Mammary Glands.; *Woods, A. S. ; Cotter, R. J.; Sypniewska, R.; Wooley, P.; Pharmacology, Johns Hopkins University Medical School, Baltimore MD Phosphorylation of Transcriptional Coactivator PC4; *Zhao, Yingming ; Qin, Jun; Mirza, Urooj A; Chait, Brian T.; The Rockefeller University, 1230 York Avenue, New York, NY 10021 Quantitative Measurement of Some DMAP-TH Amino Acid Derivatines with MALDI TOF MS; *Zhou, Jie; **Bailey, Jerome; Lee, Terry; Beckman Research Institute of the City of Hope, Duarte, CA 9 IO1 0
SPRAY IONIZATION
- FUNDAMENTALS
Abstracts are arranged alphabetically byfmt author WPM WPM WPM WPM
Short-Time Observation of An Electrospray CurentComparison of Positive and Negative Ionisation; *Beaugrand, Claude; Rolando, Christian; Charbonnier, Florence; Simmoneau, Gerard; Ecole Normale Superieure, Departement de Chimie, Paris (France) Study of Metal-Ligand Interactions with Electrospray FTICR Mass Spectrometry; *Eyler, John; Richardson, David; Burton, Richard; Yang, Yarjing; Watson, Clifford; Department of Chemistry, University of Florida, Gainesville, Florida Weighing Intact Virus Particles with a Charge Detection Mass Spectrometer; *Fuerstenau, Stephen D.; Benner, W. Henry; Lawrence Berkeley National Laboratory Optimization of different emitter designs for electrospray ionization applications; *Gale, David C.; l *Khosla, Mike; Mylchreest, lain; Sweeney, Matt J.; Josephs, Jonathan L.; Sanders, Mark; Finnigan MAT, San Jose CA
. 416 . WPM WPM WPM WPM WPM WPM WPM WPM WPM WPM WPM WPM WPM WPM WPM WPM WPM
WPN WPN WPN WPN WPN WPN WPN WPN WPN WPN WPN WPN
44TH
ASMS
CONFERENCE
ON
MASS
SPECTROMETRY
Analysis using MALD/I TOFMS with Electrospray Sample Preparation; Hensel,Russell;Kennedy,Cat-y; *Owens,Kevin; Hock,Rick; DrexelUniversityDepartment of Chemistry Atsumu;Hirabayashi, Yukiko; Sakairi, Multiply-Charged Ions Produced by Sonic Spray Ionization, * +Hirabayashi, Minoru; Koizumi,Hideaki;CentralResearch Laboratory,Hitachi,Ltd., Kokubunji,Tokyo 185,Japan Influence of skimmer potential on m/z distributions in ES1 spectra: Implications for polymers; Hunt, Susan,M.; *Sheil, MargaretM.; Derrick,Peter,J.; l *Belov, Michael;Universityof Wollongong,Wollongong.NSWAustralia Electrospray Ion Resolvstion in a Linear Time-of-Flight Mass Spectrometer; *Lasater,M.A.; Laude,D.A.; The Universityof Texasat Austin Electrospray mass spectrometry of sillver-containing adducts of peptides and proteins.; Li, Hongbo;*Siu, K.W. Michael; Guevremont,Roger;Inst.Nat. Measurement Stds.,NationalResearch Councilof Canada,Ottawa Fundamental Studies Toward the Analysis of Polymerized Monolsyers by ESDMS; *McCarley,TracyDonovan; McCarley,RobinLindsey;DuBois,C.J.;Department of Chemistry,LouisianaStateUniversity,BatonRouge,LA 70803 Non-linear Model of ES1 for Multicomponent Quantitation of Illicit Heroin Samples; Selby,David S. ; *Guilhaus, Michael;Wells[l], Robert; Murby[l], John; Schoolof Chemistry,Universityof New SouthWales,Sydney2052Australia Performance of a New Atmospheric Pressure Ion Source for Magnetic Sector Mass Spectrometers; *Shen,Shida; Whitehouse, Craig;Analyticaof Branford,Inc. Optimization of APCI LClMS Conditions for the Analysis of Polycyclic Aromatic Hydrocarbons; *Smith,RichardW.; Marvin, ChrisH.; McCany,BrianE.; Department of Chemistry,McMasterUniversity,Hamilton,ON, L8S4M1, CANADA Flowing Afterspray. Combining Electrospray Ionization with the Flowing Afterglow Technique.; *Squires,RobertR.; Sunderlin,LeeS.; Chyall,LenJ.; Hill, BrianT.; Hu, Jun;Poutsma, JohnC.; Seburg,RandalA.; Byrd, Dana;Purdue University,Department of Chemistry,WestLafayette,IN 47907 Location of Charge Sites in Doubly Protonated Angiotensin II Ions Formed by ES1 (Part I); *Sullards,Cameron;Adams, Jeanette;Department of Chemistry,EmoryUniversity,Atlanta,GA 30322 Sensitivity Enhancement of ESI-MS by Operating in the Corona-Assisted Cone-Jet Mode; *Tang,Keqi; Smith,Richard D.; PacificNorthwestNationalLaboratory,Richland,WA Oxidation of Gas-Phase Peptide-Copper Ternary Complexes with Alkali Metal Cations; Vaisar,Tomas;Gatlin, Christine; l Turecek,Frantisek;Universityof Washington, Seattle,WA Electrospray as an Electrolysis Cell: Electrochemical Ionization of Neutrals for Detection by ES-MS; *Van Berkel,Gary ; Zhou,Feimeng;OakRidgeNationalLaboratory Quantitative
Solvent and Counterion
Effects on Observed Charge States of Diquaternary
Ammonium
Salts in ESI-MS;
*Wang,
Guangdi;Cole,RichardB.; Department of Chemistry,Xavier University,New Orleans,LA 70125 Physical Processes of Electrospray Ionization; *Willoughby,Ross;Sheehan, Edward;Chem-Space Associates ion Pairing Effects of TFA in Electrospray Ionization Mass Spectrometry; *Wolf, Barbara;Russell,DavidH.; Texas A&M University COMBINATORIAL LIBRARIES Abstracts are arranged alphabetically byfirst author Optimization of pp60c-src Substrates by Decoding Peptide Libraries Using LCIMS; *Blackbum,Kevin; Kassel,Daniel; Tian, Gaochao;Knight, Blame;Glaxo Wellcome,Inc. Pharmacokinetic Characterization of Combinatorial Libraries; *Bodnar,Wanda;Geysen,Mario; Wagner,David; GlaxoWellcomeResearch Institute Screening of Combinatorial Libraries using Electrospray Ionization FTICR; *Fang,Annette;Vouros,Paul;**Stacey, Catherine;Kruppa,Gary;Laukien,Frank;Carell,Thomas;Wintner,Edward;Rebek,Jr., Julius;Northeastern University, BamettInstitute,Boston,MA Single bead mass spectrometry in quality assurance of combinatorial libraries; *Fitch, WilliamL.; Shah,Nikhil; Af@max Research Institute A Question of Cell Permeability: Additional Information Gleaned from Combinatorial Libraries; *Kassel,DanielB.; Cheng,Soan;Bonner,Ron;Burton, Ron;Knipp,Greg;**Borchart,Ron;CombiChem, Inc. 9050CaminoSantaFe, San Diego,CA 92121 Library Affinity Selection-Mass Spectrometry: Characterization of SH2-Ligand Interactions; *Kelly, MicheleA.; Liang,Hongbin;Sytwu,IOU-IOU; Wennogle,LawrenceP.; Ciba-GeigyCorp.,Pharmaceuticals Div., 556Morris Avenue, Summit,NJ 0790I Automatic Multipledimensional HPLC Coupled with Mass Spectrometry for Qualitative Method Development; *Li, Lily Y.T.; Kyranos,James N.; ArQule Inc. 200BostonAve. Suite3600,Medford,MA 02155 Combinatorial Library Automation for Bapid APCI Analysis; *McKay, Richard;Larsen,Barbara;Livingston,Robert; Doughty,James; DuPontCentralResearch & Development, Wilmington,DE The Potentials of ES1 and MALDI-FIMS in Addressing Structural Diversity of Combinatorial Libraries; *Ross, CharlesW.; Ramjit,Harri G.; **Speir,J. Paul;Laukien,Frank,Stacey,Catherine;Kruppa,Gary H.; Merck & Co. Div. MRL, WestPoint,PA Analytical Protocol for LC/MS and LCIMSIMS Profiling of Combinatorial Libraries; *Rourick,RobynA.; Whitney, Jeffrey L.; Klohr, StevenE.; Volk, Kevin J.; Kerns,EdwardH.; **Lee, Mike S.;Bristol-MyersSquibbWallingford,CT 06492 Qualitative and Quantitative Methods foDecodingEncodedCombinatorial Libraries; *Shah,Nikhil; Fitch, William L.; AfQmax Research Institute Mixture Analysis of Biphenyl Diamides Using LC/APCI/MS; *Smith,RonaldG.; Woodard,Scott;Leschinsky,Kindrick ; MonsantoCompany,St.Louis
PRELIMINARY
WPN WPN WPN WPN WPN
417
PROGRAM
of lignndkeceptor interactions using electrosprny LC/MS; *van Breemen. RichardB.; Huang,Chao-Ran; Nikolic, Dejan;Woodbury,CharlesP.; Zhao,Yong-Zhong;Venton,DuaneL.; Universityof Illinoisat Chicago,Chicago, Illinois Predictive Combinatorial Degradation Profiling; *Volk, Kevin ; Rourick,Robyn;Whitney,Jeffrey; Spears, Tony; Kerns, Edward;Lee,Mike; Bristol-MyersSquibbWallingford,CT 06492 Automated Mass Spectral Data Analysis for Combinatorial Chemistry; *Wagner,David;Bodnar,Wanda;Schoenen, Frank;Geysen,Mario; GlaxoWellcomeResearch Institute Using Scientific Visualization Software to Analyze Structural Trends in LC/MS Profile Datasets; *Whitney, Jeffrey L.; **Hail, Mark E.; Rourick,RobynA.; Volk, Kevin J.; Kerns,EdwardH.; Lee,Mike S.;Bristol-MyersSquibbWallingford,CT Quantification
06492 Combinatorial
library screening by immuno-affbtity
coupled with ion-spray MS; +Wieboldt,Ray;Henion,Jack;
Analytical Toxicology, CornellUniversity,IthacaNY WPN
Characterization
of Peptide Combinatorial
Libraries
By Direct Infusion and HPLC ESI-FT/MS;
*Winger,Brian;
Castoro,John;FTMS, Inc., 6416Schroeder Rd., MadisonWI, 5371l-2424 WPN WPN WPN WPN WPN
Predictive Proflling Using Universal LC/MS Techniques; Beyer,Barbara;*Starrett,Anne; Thompson, William;DiDonato,Gerald;Lee,Mike; Bristol-MyersSquibbCompany,Princeton Direct Characterization of Solid Phase Resin-Bound Molecules by Mass Spectrometry; Fitzgerald,Micheal;Harris,Ken; Shevlin,Charles;*Siuzdak,Gary; TheScrippsResearch Institute,La Jolla,California Automated High Throughput LC/MS for the Rapid Profiling of Pharmaceutical Compounds; Hail, Mark E.; *Warrack, BethanneM.; Arroyo, AnneStarrett;DiDonato,GeraldC.; Lee,Mike S.; Bristol-MyersSquibbPharmaceutical Research Institute,Princeton,NJ Automated LC-MS for the Characterisation of Combinatorial Libraries.; Preece,Steve;Batt, Jeremy;*Rontree,John; **Bott, Peter;VG Organic,Altrincham,WA14 5RZ, UK. Screening combinatorial libraries using pulsed ultrafiltration/electrospray mass spectrometry; vanBreemen, RichardB.; *Huang,Chao-Ran;Nikolic, Dejan;Woodbury,CharlesP.; Zhao,Yong-Zhong;Venton,DuaneL.; Universityof Illinoisat Chicago,Chicago,Illinois Rapid Lipopbilicity
PROTEINS
AND PEPTIDES
Abstracts are arranged alphabetically byfirst author WPO WPO WPO WPO WPO WPO WPO WPO WPO WPO WPO WPO WPO WPO WPO WPO
Peptide Mapping with On-line Capillary Electrophoresis/Electrospray Mass Spectrometry; *Apffel, Alex; Chakel,John;Udiavar,Sharmila;Hancock,William; Swedberg, Sally; **Pungor, . Emo;M’Timkulu,Thabiso;Hewlett-Packard Laboratories,PaloAlto, CA 94304 Observing Trypsin - Protein Inhibitor Complexes by Electrospray Ionisation Mass Spectrometry.; *Aplin, Robin; Kraunsoe,James;Lowe,Gordon;**Green,Brian;Oxford Centrefor MolecularSciences,Oxford University,Oxford,UK. OX1 Glycoprotein
3QY
Characterization of Recombinant Human Factor VIII; Besman, Marc; *Medzihradszky,Katalin; Maltby, David; Burlingame,Alma; MassSpectromeby Facility, Universityof California,SanFrancisco Determination of the Extent and Position of Glycosylation in Mucins; *Cai,Zongwei;Cemy,RonaldL.; Hollingsworth, MichaelA.; Department of Chemistry,Universityof Nebraska-Lincoln Structural Characterization of the Glycoprotein alpha-N-Acetylgalactosaminidase; *Carroll,James; Beavis,Ronald;Zhu, Alex; TheSkirballInstitue,NewYork UniversityMedicalCenter,New York, NY Noncovalent Quaternary Protein Analysis by MALDI Mass Spectrometry; *Cohen,Lucinda;Strupat,Kerstin; Hillenkamp,Franz;Institutefor Med.PhysicsandBiophysics,Universityof Muenster,Germany Conformation of Gas-Phase Myoglobin Ions; *ColIings,Bruce;Douglas, Don;Dept.of Chemistry,U. of BritishColumbia Detecting Conformations and Conformational Changes by Hydrogen Exchange and Mass Spectrometry; *Deng, Yuzhong;Zhang,Zhongqi;Smith, David L.; Department of Chemistry,Universityof Nebraska-Lincoln, Lincoln,NE 68588 Observation of a higher order structure for Clostridium perfringens alpha toxins in the gas phase; *Despeyroux, Dominique;Lingard,Bryan; Titball, Rick; Watts,Peter;ChemicalandBiologicalDefenceEstablishment, PortonDown, Salisbury Mass Spectrometric
Detection of Protein Conformations
by On-line Rapid Hydrogen Exchange and Protein Fragmentation/MS;
*Dharmasiri,Kuruppu;Smith,David L. ; Universityof Nebraska-Lincoln, Lincoln,NE 68588 Correlations Between Protein X-ray Structures and Electrospray Mass Spectra; l Eckart,Klaus;Verhey,Janko;Spiess, Joachim;Max PlanckInstitutefor Experimental Medicine Dominant Forces in Gas-Phase Conformations of Protein Ions; *Guan, Ziqiang;Wood,Troy D.; Kelleher,Neil L.; Aaserud,DaveJ.; McLafferty, FredW.; CornellUniversity,Ithaca,NY Local influence of mutations in a cytochrome cS53 probed by isotopic exchanges and ESI-MS; Guy, Philippe;R migy, Herv ; Jaquinod,Michel; Bersch,Beate;Blanchard,Laurence;**Dolla, Alain; Gagnon,Jean;*Forest,Eric; InstitutdeBiologie StructuraleCEA-CNRS,Grenoble,France Characterization of Protein-Folding Intermediates by Chemical Trapping and Mass Spectrometry; Happersberger, Peter;Cowgill, Cynthia;Deinzer,Max L.; *Glocker,Michael0.; Universityof Konstanz,POBox5560M732,D-78434 Konstanz,Germany Mapping of In Vivo Phosphorylation in Human VDR Protein by Phosphopeptide-selective MS; l Billiard, GeorgeM.; Huddleston,MichaelJ.; **Pike,J. Wes;Can; StevenA.; SmithKlineBeecham Pharmaceuticals, King of Prussia,PA Selective Detection and Sequencing of Phosphopeptides at the Femtomole Level in Protein Digests; *Huddleston, Michael;Annan,Roland;Can; Steven;SmithKlineBeecham Pharmaceuticals, King of Prussia,PA 19406
.
418
44TH
ASMS
CONFERENCE
ON
MASS
SPECTROMETRY
*
WPO WPO WPO WPO WPO WPO WPO WPO WPO WPO WPO WPO WPO WPO WPO WPO WPO WPO WPO WPO WPO WPO WPO WPO
Detection of Phosphorylnted and Sulfated Peptides in Total Tryptic Digests by Negative-Ion ESI-MS; l Jedrzejewski, Paul; Lehmann, Wolf D.; German Cancer Research Center Proteolytic Digest and Secondary Structure with MALDI; Kriwacki, Richard; +Wu, Jiangyue; Wright, Peter; Siuzdak, Gary; The Scripps Research Institute, La Jolla, California Chnracterixation of Gastrointestinal Peptides by Desorption Ionixation; *Larsen, Barbara; McKay, Richard; Gutteridge, Steven; Vestling, Martha; DuPont Central Research & Development Estimating solution binding constants of Src SH2 domains with an API MS/MS system; *Le Blanc, J.C.Yves; l *Dalgamo. David; PE-Sciex, 71 Four Valley Drive, Concord (Ontario) L4K 4V8 Competition between protein unfolding and amide hydrogen exchange determined by HR ESIMS.; *Lund, Eric; Smith, David L.; Department of Chemistry, University of Nebraska, Lincoln, NE, 68588-0304 Protein solution conformations and folding intermediates studied by H/D exchange/ESI-MS; l Maier, Claudia, S.; **Englen, Mark; Kim, Ok-Hee; Schimerlik, Michael, I.; Deinzer, Max, L.; Department of Agricultural Chemistry Characterization of Glycoprotein Components Using Off-line CEMS; l McComb, Mark Perreault, Helene; University of Manitoba, Chemistry Department, Winnipeg, Manitoba, Canada Mapping Phosphorylations by Precursor Scans of Unseparated Peptide Mixtures of Gel Isolated Proteins; Neubauer, Gitte; Wilm, Matthias; *Mann, Matthias; European Molecular Biology Laboratory, Heidelberg Determination of Protein Reactive Sites by Multiple SORI Experiments in ElectrospraylFTICR; *Robinson, J.M.; Bolanos, B.J.; Arkin, R.C.; Campbell, V.L.; Laude, D.A.; The University of Texas at Austin Identification of Protein Phosphorylation Sites by Capillary IMACl LCI ESI-MS.; *Russo, Paul; Falchetto, Rocco; Hendrickson, Ronald; Shabanowitz, Jeff, Hunt, Donald; Smith, Gregory; University of Virginia, Charlottesville Structure determination and functional characterization of succinylated Porin from Rhodobacter caps.; *Schnaible, Volker; Blueggel, Martin; Glocker, Michael 0.; Przybylski, Michael; **Nestel, Uwe; Diederichs, Kay; Welte, Wolfram; Universitaet Konstanz, Fakultaet her Chemie, 78434 Konstanz, FRG H/D exchange studies of peptide fragments comprising protein domains by ESI- MS; l Shen, Tun-Li; Gage, Douglas A.; Dept. of Biochemistry, Michigan State University, East Lansing, MI 48824 Analysis of Lipoproteins by MALDI and ES1 Mass Spectrometry; *Song, Siqing; Hu, Allison; Macfarlane, Ronald; Texas A&M University Cu(II)-Peptide Complexes Studied by Mass Spectrometry and Capillary Electrophoresis; *Song, Siqing; Hu, Allison; Bondarenko, Pavel; Cruzado, Ingrid; Macfarlane, Ronald; Texas A&M University ESEMS and MALDI-TOF MS Analysis of Zinc Binding by HIV nc p7 Peptide; *Sumpter, Terry; Sowder, Raymond, II; Kane, Bradley; Henderson, Louis; SAIC-Frederick, NCI-FCRDC, Frederick, MD Protein Glycosylation Analysis Using LC/ESYMS/MS on an Ion Trap Mass Spectrometer; *Sweeney, Matt; Josephs, Jonathan; Gale, David; Sanders, Mark; Chaudhary, Tanuja; Finnigan MAT, 355 River Oaks Parkway, San Jose CA, 95134 Salt and ligand induced protein conformational changes probed by H/D exchange using ESI-MS & LC-MS; *Tang, Xue-jun; Wang, Fang; Albert Einstein College of Medicine Mass Spectrometry of Dethiobiotin Synthetase Non-Covalent Complexes; * Vestling, Martha; Larsen, Barbara; Reiser, Robert; Fogiel, Arthur; Gibson, Katharine; Johnston, Murray; DuPont Central Research & Development Mass specrometric investigations of noncovalent protein-protein interactions using ESI-sector MS; *Wang, Jianyao; Busman, Mark; Knapp, Daniel R.; Dept. of Pharmacology, Medical Univ. of South Carolina, Charleston, SC, Analysis of Peptide Aggregation with Pulsed Field Gradient NMR and ES1 MS; l Williams, Todd D.; Mansfield, Shawn; Jayawickrama, Dimuthu; Larive, Cynthia K.; University of Kansas, Lawrence 66045 O-linked Glycosylation Site Identification by Pronase DigestionlMALDI-MS; *Yang, Yi; Levin, Todd; Austin, Troy; Orlando, Ron; CCRC, University of Georgia, Athens, GA 30602 Analysis of glycoforms of glycoproteins by capillary electrophoresis-electrospray mass spectrometry; l Yeung, Bemice; Yim, KaIvin; Vath, James; Genetics Institute, Inc., Andover, MA 01810 Higher-Order Structure of Gas-Phase Peptides and Proteins from Gas-Phase H/D Exchange Experiments; *Zhang, Zhongqi; Li, Weiqun; Logan, Timothy M.; Guan, Shenheng; Marshall, Alan G.; National High Magnetic Field Lab, Florida State Univ., Tallahassee, FL Analysis of phosphopeptides by using liquid chromatography/mass spectrometry; Zhu, Xirong; *Dass, Chhabil; Department of Chemistry, The University of Memphis, Memphis, TN 38 152
THURSDAY
POSTERS
ION SOURCE AND MS INSTRUMENTATION
Abstracts are arranged alphabetically byfirst author ThPA ThPA ThPA ThPA
Quantification of Detection Limits in FTICR-MS; *Anderson, Gordon A.; Bruce, James E.; Smith, Richard D.; Pacific Northwest National Laboratory, Richland, WA Static Secondary Ion Mass Spectrometry Utilizing the Ion Trap; *Appelhans, Anthony; Dahl, David; Delmore, James; Groenewold, Gary; Ingram, Jani; Idaho National Engineering Laboratory, Idaho Falls, ID Improved MS/MS Performance on the NERMAG R 3010 Triple Quadrupole Mass Spectrometer; +Bruins, Andries P.; University Centre for Pharmacy, Groningen, The Netherlands Effects of desorption geometries for ions derived from MALDI on the ion trapping in FTICRMS; +Chan, T-W. Dominic; Wong , Carol K.L.; The Chinese University of Hong Kong, Hong Kong
PRELIMINARY
YhPA ThPA ThPA ThPA ThPA ThPA ThPA ThPA ThPA ThPA ThPA ThPA ThPA ThPA ThPA ThPA ThPA ThPA ThPA ThPA ThPA ThPA ThPA ThPA
419
PROGRAM
Focusing of Ions in the Electrospray TOF Mass Spectrometer: +Chemushevich, Igor V.; l *Tolmachev,Alexei V.; Krutchinsky.AndrewN. [I 1; Spicer,Victor L. [I]; Ens,Werner[I]; Standing,KennethG, [I]; PhysicsDept.,Universityof Manitoba,WinnipegMB Canada R3T 2N2 Average Ion Kinetic Energy Distributions in a Radio Frequency Glow Discharge Source; *Christopher, StevenJ.; Marcus,R. Kenneth;Clemson University.Department of Chemistry,Clemson, SC29634-1905 Extended Mass Range Quadrupole Mass Spectrometer; *Callings,Bruce;Douglas, Don; Dept.of Chemistry,U. of British Columbia,Vancouver,B.C. Devices to Guide Ions from Sources to Consumers: A Systematic of Ion Guides; *Franzen,Jochen;Bruker-Franzen Analytik GmbH,Bremen,Germany Development of a New Benchtop Double-Focusing Magnetic Sector Instrument For LCIMS; Fujimaki,S.; Ishihara,M.; *Kunihiro,F.; Finch,Jeffrey W.; Cody,RobertB.; Kammei,Y.; Kubota,E.; JEOLLTD., l-2, Musashino 3-chome, Akishima,Tokyo 196,Japan Combining FT-ICR with Ion Mobility Spectrometry (IMS); *Gillig, Kent;Bluhm,Brian;Russell, David; TexasA&M University CollegeStation Quantitation Methods in Fourier Transform Ion Cyclotron Resonance Mass Spectrometry (FT-ICI&MS); l Goodner, Kevin; Milgram,Eric; Watson,Clifford; Eyler,John;Department of Chemistry,Universityof Florida,Gainesville,FL. Collisional
Glow Discharge Fourier Transform
Ion Cyclotron Resonance Mass Spectrometry(GD-FTICRMS)
at High Field;
*Goodner,Kevin; Milgram,Eric; Dejsupa,Chadin;Watson,Clifford; Eyler, John;**Barshick,Christopher; Department of Chemisty,Universityof Florida,Gainesville,FL Microsecond Pulsed Glow Discharge Mass Spectrometry; *Hang,Wei; Baker,Cynthia;Smith,Ben;Winefordner,Jim; Harrison,Willard; Department of Chemistry,Universityof Florida,Gainesville,FL 32611 TOF-SIMS Using keV Energy C60 Primary Ions; *Harris,Ronny;VanStipdonk,Mike; Schweikert,Emile;Department of Chemistry,TexasA&M University,CollegeStation,Texas Design and performance of a hybrid tandem mass spectrometer with BE/ion trap configuration; Huels,Wilfried; Muenster,Helmut;Pesch,Reinhold;*Schroeder, Ernst;FinniganMAT GmbH,Barkhausenstr.2, D-28197Bremen,Germany. Phosphopeptide Analysis By Microspray Ionization - Hybrid Quadrupole/Ion Trap Mass Spectrometry; *Jonscher, KarenR.; Yates,JohnR., III; Dept.of MolecularBiotechnology,Universityof Washington, Seattle,WA A dual cell mounted in an external source QFTMS, for the study of anion-cation reactions and SID.; Man,Fu Cheong; Penn,SharronG.; Green,M. Kirk; *Lebrilla,CarlitoB.; Department of Chemistry,Universityof California,Davis Development of a Portable High Resolution Fourier Transform Ion Cyclotron Mass Spectrometer; *Miller, Gregory; Koch,Mathias;Hsu,J.P.; Southwest Research Institute An Improved Ion Guide Interface for Electrospray LC/MS; *Mordehai,Alex; Buttrill, Jr., S.E.; VarianResearch Center, 3075 Hansen Way, PaloAlto, CA 94304-1025 Water Cluster Formation in a Novel Low Power Radio Frequency Glow Discharge; *Mowat, Ian A; Todd,JohnFJ; Langford,MarianL; ChemistryDepartment, Universityof Kent,Canterbury,Kent,CT2 7NH,UK Extended Mass Enhancement for a Commercially Available Quadrupole Mass Spectrometer Series; l Niemann,Scott; **SchiIling,Alexander;CSSCompany,Shawnee Kansas Can Ion Trap LCIMSIMS Replace Quadrupole LC/MS/MS in Quant. Drug Analysis?; *Paulson, Jan;**Cunniff, Jack; Schwartz,Jae;AstraDracoAB, Lund,Sweden Optimizing Quadrupole Performance When Coupled With High Voltage Ion Sources; *Pedder,Randall;Schaeffer, Richard;,ABBExtrel, 575EpsilonDrive, Pittsburgh,PA 15238 Resolving Isobaric Masses Using a Quadrupole Operated in the Second Mathieu Stability Region; *Pedder,Randall; Schaeffer,Richard;ABB Extrei, 575EpsilonDrive, Pittsburgh,PA, 15238 Double cylindrical electrode electrostatic ion-guide for API-MS; *Takada,Yasuaki;Nabeshima, Takayuki;Sakairi, Minoru; Koizumi,Hideaki;CentralResearch Laboratory,HitachiLtd., Tokyo,Japan RF-Only Quadrupoles With Axial Fields; *Thomson, Bruce;Jolliffe, Chuck;Javahery,Reza;SCIEX,Concord,Canada. TOF-SIMS Using Metal-Oxide Clusters as Primary Projectiles, * *Van Stipdonk,Mike; Harris,Ronny;Ferrell,Ricky; Schweikert,Emile;Department of Chemistry,TexasA&M University,CollegeStation,Texas An External Source 7 Tesla FT-ICR Mass Spectrometer with Electrostatic Ion Guide; *White, Forest;Marto,Jarrod; Marshall,Alan; NationalHighMagneticFieldLab,FloridaStateUniv., Talllahassee, FL COMPUTER APPLICATIONS
Absfracts are arranged alphabeticah’y byfirst author ThPB
Application
of Wavelet Transforms
to Electrospray
Spectra: Denoising, Smoothing, and Compression;
*Barclay,V. J.;
Bonner,R. F.; **Hamilton,I. P.;PESciex,Toronto ThPB ThPB ThPB ThPB ThPB
Mass Spectrometry - Sample Dependent Data Processing; *Banner,Ron;Burton,Lyle; Covey,Tom; **McLean,Matt; PESciexInstruments, Toronto,Canada The MassSpectrometry Internet Site - Experiences of the First Year; * Bostwick,David; Shealy,Sarah;Busch,Kenneth; Schoolof Chemistry& Biochemistry,GeorgiaInst.of Technology,AtlantaGA Extension of the TICFilt Data Treatment Algorithm to Separation/MS Techniques.; *Carrier,Alain; Zidarov,Dimo; Bertrand,Michel J.; Universityof Montreal,Montreal Application of SIMION 6.0 to Problems in Time-of-flight Mass Spectrometry; *Colby, StevenM.; Manura,John; ScientificInstrumentServices,Inc.
Automating
A Modular
System for Tailored
Waveform Generation
in FTICR/MS
Based on VXI and LabVIEW
Software;
l Dejsupa,Chadin;Dearden,David;Dept.of ChemistryandBiochemistry,BrighamYoungUniversity,Provo
420 . ThPB
44TH
Improved Software Tools for the Analysis of MALD/I
Time-of-Flight
ASMS
CONFERENCE
Mass Spectrometry
ON
MASS
SPECTROMETRY
Data; *Hanton,ScottD.;
Owens,Kevin 0.; Air Products& Chemicals, Inc., Allentown,PA 18195 ThPB ThPB ThPB ThPB ThPB ThPB ThPB ThPB ThPB ThPB ThPB ThPB ThPB ThPB ThPB
Excel Macros for Quantitntion in a GLP Environment; *Hayes,MichaelJ.; Carlsen,Stephen F.; Ciba-GeigyCorp.,Pharmaceuticals Div., Research Department, SummitNJ 8790 Using Fuzzy Logic to Accommodating Variance in a Molecular Structure Elucidation System; ‘Hemenway,Eric; Enke, Christie;Department of Chemistry,Universityof NewMexico,Albuquerque, NM 8713I Per;Klint, Martin; Zubarev, Algorithms of automated peptide sequencing using partial acid hydrolysis; l HCEkansson, Roman;Sundqvist,Bo U.R.; Uppsalauniversity,Sweden A Novel Algorithm to Enhance Signal to Noise Ratios in CEMS and LC-MS; *Huang,BaomingM.; Muddiman,David C.; Anderson,GordonA.; Rockwood,Alan L.; Qinyuan,Wu; **Smith,RichardD.; Proctor,Andrew;PacificNorthwest NationalLaboratory Effective Searching of Multiple EI Data Bases on Hewlett-Packard Data Systems; *Little, James; **Lob, Stanton; Stauffer,Doug;Eastman ChemicalCompany,Kingsport,TN Automated Determination of the Consistency of Mass Spectra and Chemical Structure; l Mistrik, Robert;Stein,Stephen E.; NationalInstituteof Standards andTechnology,Gaithersburg MD Fragrance creations analysis using semiautomatic spectra (MS, IR) interpretation and olfactoric data; *Nikiforov, Alex; JIirovetz, Leopold;Buchbauer,Gerhard;K(lmig,Stefan;Inst.Org.Chem.,Univ.Vienna,Wahringerstr.38,A-lO9O Vienna,Austria An Internet-Accessible, On-Line Ion Trap Mass Spectrometer for Collaborative Research; *Price,JohnM.; Gorshkov, MichaelV.; PacificNorthwestNationalLaboratory,Richland,WA 99352 ElectroSpray Spectrum Analyser: A new tool to deconvolute multiply charged spectra; *Proulx, Pascal;Zidarov,Dimo; Bertrand,Michel J.; Universityof Montreal Multi-Dimensional Visualization of Ion Trap MS% Spectra; *Sander,Peter;Bruker-Franzen Analytik GmbH,Bremen, Germany Spectral Simplification of Peptide Sequencing Data by Massive Inference; Skilling I, John;*Ferrige,AnthonyG.; Green 3, Brian; **Zhang,X. Kate; l)MaxEnt SolutionsLtd. Isle.,ELY, Camb.,UK; 3)VG OrganicALTRlNChes.UK Quantified ICP-MS Elemental Analysis by Massive Inference and Identification of New Interferences; Skilling,J.; *Ferrige,A.G.; **Gregson,D.; Verbogt,G.; MaxEnt SolutionsLtd. Isleham,ELY, Cambs.,UK CB7 5RX Mass Spectral Identification Using Substructure Information Generated from Library Searches; *Sparkman,0. David; 0. David Sparkman & Associates Data Controlled Modification of the Chromatographic Time Frame Using Feedback Flow Modulation; *Stahl,Douglas C.; Davis,MichaelT.; Lee,Terry D; BeckmanResearch Instituteof the City of Hope,DuarteCA 9IOIO Development of a GUI Based Data Reduction Program for FTICR and TOF Mass Spectrometry; *Watson,Clifford H.; Goodner,Kevin L.; Eyler, JohnR.; Department of Chemistry,Universityof Florida,Gainesville,FL 3261l-7200 The Use of Modular
ION-MOLECULE
REACTIONS
Abstracts are arranged alphabetically by first author ThPC
Ion-Molecule
Reactions in FAB - Do They Really Contribute
to the Ions Observed ?; *Allison,John;Szekely,Gabriella;
Smith,Guy; Noon,Kathleen;MichiganStateUniversity,EastLansing ThPC ThPC ThPC ThPC ThPC ThPC ThPC ThPC ThPC ThPC ThPC ThPC ThPC
of ion formation, fragmentation and collisions using DC and pulsed ion extraction; Arnold, Randy; Christian,Noah,*Reilly, James;Department of Chemistry,IndianaUniversity,Bloomington,Indiana SIFT/CID Studies of the Ligation of Fe+ and (c-CSHS)Fet with Hydrocarbons.; Baranov,Vladimir; Becker,Hansjuergen; Schwarz,Helmut;*Bohme,Diethard,K.; York University,NorthYork, Ontario,Canada The Role of Radiative Relaxation in the Fe+ Catalyzed Polymerization of Chlorobenxene; *Bjamason, Asgeir;Ridge, Douglas;Universityof Delaware,Newark,DE A Structural Study of the Metallo-Carbohedrene Nb8C12+; *Byun, Yong ; Lee,Samuel;Kan,Steve;Freiser,Ben;Purdue University,WestLafayette,Indiana Comparison of different FeCX+ complexes through their ion-molecule reactivity; *Capron,Laure;Mestdagh,Helene; Rolando,Christian;EcoleNormaleSuperieure, Paris(France) Eric; Mestdagh,Helene; Gas-phase reactivity of small and large Fe(IUO)n+ cluster ions; *Capron,Laure;Delcominette, Rolando,Christian;Sablier,Michel; Pradel,Pierre;Visticot,Jean-Paul; Mestdagh,Jean-Michel;EcoleNormaleSuperieure, Departement de Chimie,Paris(France) Gas Phase Coordination Chemistry: How is it Relevant to Condensed Phase Coordination Chemistry?; *Fisher,Keith; Williams,Brett; Dance,Ian;Willett, Gary;Schoolof Chemistry,Universityof New SouthWales Organolanthanide complexes from reactions of laser-ablated lanthanide ions with cyclic hydrocarbons; *Gibson,John K.; OakRidgeNationalLaboratory Chiral Selectivity in Gas-Phase Proton Transfer: Reactions of Amines with Cytochrome c; *Green,M. Kirk; Camara, Elvira J. 0.; Penn,SharronG.; Lebrilla,CarlitoB.; Universityof California,Davis Solvation Effects on the Stability and Reactivity of Multiply Charged Gas-Phase Ions; *Gross,Deborah;Zhao,Yuexing; Williams,Evan;Universityof California,Berkeley Radiative association rates and bond strengths of metal ion complexes; *Ho, Yen-Peng; Dunbar,RobertC.; Department of ChemistryCaseWesternReserveUniversity Gas-Phase Reactions of Fullerene Ions with Ozone; *Holliman,Christopher; McElvany, Stephen; Naval Research Laboratory;Washington,D.C. 20375 Gas Phase Solvation Effect on Proton Transfer: Case Study of Amino Acid Solvated by Ammonia; I-hag, Yang; *Russell,David H.; TexasA&M University,CollegeStation Investigations
PRELIMINARY
ThPC
421
PROGRAM
Reactions of Nicotine Analogs:
Functional
Group Selectivity of Electrophiles;
l
Isbell,John;BrodbelfJennifer;Seeman,
Jeffrey; UniversityTexasat Austin,Austin ThPC ThPC ThPC ThPC ThPC ThPC ThPC ThPC ThPC ThPC ThPC ThPC ThPC ThPC ThPC ThPC ThPC ThPC ThPC ThPC ThPC ThPC
and Catalytic Activity of (Ptn)+ Ions, n = l-4; *Jackson, GeorgeS.;Hammill,Cindy; Clark,RonaldJ.; Marshall,Alan G.; NationalHighMagneticFieldLab,FloridaStateUniv., Tallahassee, FL Cns-Phase Ion-Molecule Reactions of C6OCoFe+; *Kan, Steven;Byun,YongGwan;Freiser,Ben;PurdueUniversity,West Lafayette Coupling Reactions of Gas Phase Fe(benxyne)+ and Fe(naphthyne)+ by FTMS; *Kan, Steven;Freiser,Ben; Purdue University,WestLafayette The Use of Trimethyl Borate as a CI Reagent for the Analysis of Biologically Active Molecules; *Kempen,Esther; Brodbelt,Jennifer;Universityof Texasat Austin,AustinTX. Ion-Molecule Reactions with Hydrogen Cyanide in a Ion Trap Mass Spectrometer; *Koenig,Stefan;Kofel, Peter; Schlunegger, UrsP.; Instituteof OrganicChemistry,Universityof Bern,CH-3012Bern Determination of the Gas-Phase Acidities of Uracil , S-Fluorouracil, and Thymine by Ff-ICR MS; l Li, Weiqun; Santos,Ivan;Marshall,Alan G.; NationalHighMagneticFieldLab,FloridaStateUniv., Tallahassee, FL Transition Metal Transfer Between Crown Ethers; l Liang,Yongjiang;Dejsupa, Chadin;Pope,R. Marshall;Dearden, David; Dept.of ChemistryandBiochemistry,BrighamYoungUniversity,Provo Radiative association reactions of chromium cation with benzene and benzene derivatives; *Lin, Chuan-Yuah;Dunbar, RobertC.; Department of Chemistry,CaseWesternReserveUniversity Comparison of Halocarbon - PAH Ion Molecule Reactions in an Ion-Trap and a Quadrupole Source; Mosi, Andrew; Cullen,William; *Eigendorf,Guenter;Universityof BritishColumbia,Department of Chemistry Ion-molecule complex lability in the gas phase for alkali metal ion-crown ether systems; l Nicoll, Jeremy;Dearden, David; Dejsupa,Chadin;Dept.of ChemistryandBiochemistry,BrighamYoungUniversity,Provo FT ICR study of chirality effect in the formation of protonated and ammoniumated dimers and trimers; *Nikolaeva, Marina;Nikolaev,Eugene;**Ridge,Douglas;Futrell,Jean;TheInstituteof Energyproblems of ChemicalPhysics,Moscow, Russia Clustering Reactions of Metal Ions in Excited Electronic States ; *Peterman, Scott;Russell,David;TexasA&M University CollegeStation Regioselective protonation and SN from epimeric 1,Ccyclohexanediol derivatives; Rathahao, Estelle;Perlat,MarieClaude;*Foumier,Francoise;Tabet,Jean-Claude; UniversityPierreandMarieCURIE(PARIS) Proton Transfer Reactions of Doubly Protonated Diamines Containing Polarixable Groups; *Rodriguez-Cruz, SandraE.; Williams,EvanR.; Universityof California,Berkeley Temperature and Size Dependence of Radiative Association Rates.; * Ryzhov,Victor ; Dunbar,RobertC.; Klippenstein, StephenJ.; Department of Chemistry,CaseWesternReserveUniversity Electrospray of Alkaline Earth Halides and Ligand Exchange Reactions of Their Crown Ether Complexes; *Shen, Nanzhu;Pope,R. Marshall;Dearden,David;Dept.of ChemistryandBiochemistry,BrighamYoungUniveristy,Provo Reactions of Hydantoin and Succinimide Anticonvulsants with Dimethyl Ether Ions in a QIT; *Shen,Jim;Brodbelf Jennifer;Universityof Texasat Austin Determination of the stereochemistry of Ni/carbohydrate complexes using FAB and ESI-tandem MS; *Smith,Glenn; Leary,JulieA.; Collegeof Chemistry,Universityof California,Berkeley,CA 94720-1460 Gas-phase Reactions of Biopolymers in a MALDI QUISTOR TOF-MS; l Stoeckli,Markus;Kofel, Peter;Schlunegger, l-h-s P.; Instituteof OrganicChemistry,Universityof Beme,Switzerland ELECTROSPRAY ION TRAP MS(n) MAPPING OF SURFACTANTS; *Strife, RobertJ.; Ketcha, MarciaM.; Procter8c GambleMiami Valley Laboratories, Cincinnati,OH
Generation
ELECTROSPRAY ION TRAP MS(n) OF SURFACTANTS - VERY UNSATURATED IONS FROM SATURATED AMIDES: *Strife, RobertJ.; Ketcha,MarciaM.; Procter& GambleMiami Valley Laboratory,Cincinnati,OH Electronic Effects in the Gas Phase Reactions of Ta+, Pt+ and Au+ with Small Alkenes; *Taylor, William; Campbell,
Allyson; Department of Chemistry,Universityof CentralArkansas,Conway,AR 72035 ThPC
Ligand Effects in C-H and C-C Bond Activation
by Gas-Phase Transition
Metal-Ligand
Complexes; l Tjelta, BrendaL.;
Armentrout,P.B.; Department of Chemistry,Universityof Utah,SaltLakeCity, UT ThPC
IInfrared
Photodissociation
of Gas Phase Cluster Ions in a FTICR Spectrometer;
*Tanner.Scott;McMahon,Terry;
Universityof Waterloo ThPC
Mass Spectrometry of Tin Sulfide; *Willett, Gary;Jackson, Phillip;Dance,Ian; Fisher,Keith; Gadd,Gerry; Schoolof Chemistry,The Universityof NewSouthWales,Sydney,NSW 2052. ION ACTIVATION AND DISSOCIATION Laser Ablation
Abstracts are arranged alphabetically byfIrst author ThPD
Dissociation
of methyl, ethyl and iso-propyl
phenyl esters.; *Aubry, Christiane; Holmes,JohnL.; ChemistryDepartment,
Universityof Ottawa,Ottawa,Ontario,Canada. ThPD ThPD ThPD ThPD
Induced Desolvation and Dissociation of Ions in a New ES1 TOF Mass Spectrometer; ‘Bondarenko,Pavel; Song,Siqing;Macfarlane,Ronald;Department of Chemistry,TexasA&M University,CollegeStation,TX 77843 Role of isomeric structures in mechanism and energetics of fragmentation, the case of benzene ion.; *Chawla,Rahul; Shukla,Anil; Futrell,Jean;Universityof Delaware,Newark,Delaware Hydrogen/Deuterium Exchange Reveal Hydrogen Transfer During Fragmentation of Peptide b2 Ions; *Eckart, Klaus; Spiess,Joachim;Max PlanckInstitutefor ExperimentalMedicine,Goettingen Fragmentation of a Per(onio) Substituted Benzene; *Fales,HenryM.; Zhang,X. Kate;NationalHeart,Lung,andBlood Institute,NIH , BethesdqMD 20892 Thermally
422 .
44TH
ASMS
CONFERENCE
ON
MASS
SPECTROMETRY
ThPD ThPD ThPD
ThPD ThPD ThPD WD ThPD ThPD ThPD ThPD ThPD ThPD ThPD ThPD ThPD ThPD ThPD
ThPD ThPD ThPD ThPD ThPD ThPD
Charge transfer in collisions between gaseous protein ions and inert gases.; Giannakopulos, Annastassios E.; *Andersen, Ulla N.; Christie, John R.; Reynolds, David J.; Derrick , Peter J.; University of Warwick On the Loss of 17 II from Peptide Ions; l Giblin, Daryl; Gross, Michael; Department of Chemistry, Washington University, St. Louis, MO Dissociation mechanism of hydrocarbon molecules and radicals by charge inversion mass spectrometry.; *Hayakawa, Shigeo; Endoh, Hirohisa; **Arakawa, Kazuo; Morishita, Norio; College of Integrated Arts & Sciences, Osaka Prefecture University, Sakai Energy-resolved collision-induced dissociation of deprotonated mononucleotides; Ho, Yeunghaw; l Kebarle, Paul; Department of Chemistry, University of Alberta, Edmonton, Canada T6G 2G2 To distinguish between PSD- and CID-fragment ions of peptides in a MALDI-RETOF-MS; l Koster, Claus; Holle, Armin; Bruker-Franzen Analytik GmbH,. Bremen, Germany Ortho-Cyclization of Substituted Arylcyclopropanes in Gas and Liquid Phase; l Lebedev, Albert; Mochalov, Sergei; **Tretyakova, Natalia; Hass, J. Ronald; Moscow State University, Moscow, Russia Reaction dynamics of difluoroethylene ions; *Leyh, Bernard; Locht, Robert; Franck, Beno”t; Department of Chemistry, Li ge University, B.4000 SART-TILMAN MS/MS of N and C-terminal Derivatized Peptides with a Quadrupole Ion Trap; *Lin , Tong; Glish, Gary L.; University of North Carolina at Chapel Hill Target Capture of Noble Gas Atoms by Fullerene Radical Cations.; *Mosely, Jackie. A; Gallagher, Richard. T, Derrick, Peter. J; University of Warwick Relative Reaction Cross-Sections and Dynamics for Collisional Di ssociation of the Fullerene Ions; *Nishimura, Toshihide; Pharmacia and Upjohn Inc. Low-energy CID of Molecule Ions Generated from Ricinoleic and Ricinelaidic Acid; Nizigiyimana, LibCrata; Van den Heuvel, Hilde; *Claeys, Magda; University of Antwerp (UIA) Internal Energy Effects on Low and High Energy Collision-induced Dissociation; *Ospina, Maria; Yost, Richard A.; Powell, David H.; University of Florida, Gainesville, FL. Collision Induced Dissociation of Boron Oxide Ion Clusters Studied by the Guided Ion Beam Technique.; *Peiris, Dihukshi; Lapicki, Adam; Anderson, Scott L.; University of Utah, Department of Chemistry The relationship between structure and relative CID thresholds for oligosaccharides, in MALDI FTMS; *Penn, Sharron G.; CancilIa, Mark T.; Hedrick, Jerry L.; Lebrilla, Carlito B.; Department of Chemistry, University of California, Davis, CA 95616. Experimental Evidence that Neutral Glycine has the StructureNH2-CHZ-COOH in the Gas Phase; *Polce, Michael J.; Wesdemiotis, Chrys; Department of Chemistry, The University of Akron, Akron OH 44325-3601 USA fragmentation induced by ion-atom reactions; *Rolando, Christian; Leymarie, Nancy; Poisson, Lionel; Mestdagh, Helene; Sablier, Michel; Ecole Nor-male Superieure, Paris (France) Fragmentation Pathways of Cationized Permethylated Maltoheptaose under Diverse Conditions; Reinhold, Bruce; Helin, Jari; Ngoka, Lambert; Ye, Song; Reinhold, Vernon; *Costello, Catherine; **Marshall, Alan; Boston Univ. Schoool of Medicine, Boston, MA Structural Characterization of Porphyrins by high-energy FAB CID-MS/MS; *Shibue, Toshimichi; Kambe, Hisashi; Nishide, Hiroyuki; Akashi, Satoko; Dohmae, Naoshi; Takio, Koji; **Ohashi, Yoko; School of Science and Engineering, Waseda University, Tokyo Crossed-beam study of collisional excitation of CS2+ and CO2+ at intermediate energies; *Tosh, Ronald E.; Shukla, Anil K.; Futrell, Jean H.; Chemistry and Biochemistry, University of Delaware, Newark DE 19716 Stereochemical effects in fragmentation of pentapeptides with one N-alkylated amino acid; *Vaisar, Tomas; Urban, Jan; Molecumetics Ltd., Bellevue, WA Mixed Site vs. Charge Site Remote Fragmentations of Long-chain Quaternary Ammonium Ions.; *Whalen, Kevin; Grossert, J. Stuart; **Boyd, Robert K.; Dalhousie University, Halifax, Canada MS/MS of PCB Isomers Using a Sector/Orthogonal-TOF Hybrid Instrument.; *Whalen, Kevin; Grosser& J. Stuart; **Boyd, Robert K.; Chan, Kenneth; Curtis, Jonathan M.; LeBlanc, M. Denise; Dalhousie University, Halifax, Canada Trace Detection of Electropbores by EC-FTMS; *Zhang, Tianlan; Van Orden, Steven; Laukien, Frank; Huang, Yulin; Giese , Roger; North Eastern University, Boston, MA Collision-induced dissociation of CS2++ with Ar at high collision energy; *Zhou, Xuedong; Shukla, Anil; Futrell, Jean; University of Delaware
POLYMERS, SURFACTANTS, PETROCHEMICALS
Abstracts are arranged alphabetically byfirst author ThPE WE ThPE WE WE
Chemical Ionization of Biomarkers in an Ion Trap Mass Spectrometer; *Cameron, A.S.; Roussis, S.G.; Imperial Oil, Samia Research Centre, Samia, Ontario, Canada, N7T 7Ml Characterization of Melamine Resins Using Liquid Chromatography/Mass Spectrometry; Chang, Ted; l Piquette, Michael; Cytec Industries, Stamford, CT USA Analysis of the emanations from heated polyurethane foam using MABMS.; * Cyr, Marc; Faubert, Denis; Mousselmal, Moussa; Bertrand, Miche1.J; University of Montreal, Montreal Comparison of MAB and EI for petroleum mass spectrometry; *Faubert, Denis; Mousselmal, Moussa; Roussis, Stilianos G.; Bertrand, Michel J.; University of Montreal, Montreal Computerized surfactant analysis by MS-FAB.; Hazos, Marta; Piemonti, Carmen; *Bruzual, Jenny; Mendez, Aaron; INTEVEP. S.A.
PRELIMINARY
ThPE ThPE ThPE ThPE ThPE ThPE ThPE ThPE
42:
PROGRAM
of Metalloporphyrins; *Fukuda,ElaineK.; Wang,Yanping;l *Hsu,ChangSamuel;CAFT Mass SpectrometryFacility, RutgersUniversity,NewBrunswick,NJ Unraveling the Kinetics of Petroleum Destruction by Using 1,243C2 laotopically Labeled Dopants; *Gregg,Hugh; Bumham,Alan; LawrenceLivermoreNationalLaboratory Chnracterixation of Processed Heavy Crude Oils: Resids and Asphnitener; *Hunt, Jerry; Winans,Randall;**Miller, Jeffrey; ArgonneNationalLaboratory,ChemistryDivision,Argonne Utilising Precursor Ion Scanning and MS/MS/MS Techniques for the Analysir of PolymerAdditives; *Jackson,Tony; Scrivens,Jim;Yates,Hiiary; Jennings, Richard;**Jennings, Keith; ICI Research andTechnologyCentre IWMS Analysis of Common Anionic and Nonionic Surfnctants; *Ludicky, Robert;Morton International,1275Lake Avenue,Woodstock,IL 60098 The Influence of Pump Oil Purity on Roughing Pumps; *Overton,SantfordV.; Manura,JohnJ.; ScientificInstrument Services,Inc., Ringoes,NewJersey0855I OLIGOM: A computerized mass spectrum analysis applicable to oiigomeric mixtures.; *Piemonti,Carmen;Hazos, Marta; INTEVEP, S.A. Differentiation of Isobaric Monomers Contained in Complex Polymers; * Ross,III, Charles W.; Simonsick,Jr., WilliamJ.; DuPontMarshallLaboratorv.PhiladelnhiaPA 19146 APCI LClMS
SEPARATIONS/MS
TECHNIQUES
- APPLICATIONS
Abstracts are arranged alphabetically byfIrst author ThPF ThPF ThPF ThPF ThPF ThPF ThPF ThPF ThPF ThPF ThPF ThPF ThPF ThPF ThPF
in Urine using CE-ES-MS; *Ashcroft,AiisonE.; Giles,Roger;Major, Hilary J.; McKenna,Therese;**Wilson, IanD.; VG ORGANIC,TudorRoad,Altrincham,Cheshire,WA15 5RZ,UK. Pharmaceutical Applications of CEMS for Structural Determination of Peptide Mixtures; *Ghan,Stephen;Armstrong, Barbara;Burinsky,David; Oyler,Alan; R.W. Johnson Pharmaceutical Research Institute,Raritan An Investigation of Cerebrospinal Fluid Proteins Using a New Microsprny cIEF-MS/MS System; *Clarke,Nigel J.; Johnson,KennethL.; Tomlinson,Andy J.; Kirby, DanielP.; Karger,BarryL.; Naylor, Stephen;Mayo Clinic. Rochester, MN 55905,USA The Analysis of Drugs and their Metabolites
Comparison
of Capillary
Electrochromatography/MS,
CZE/MS
and ubore LCNS
for Agrochemicals
Analysis;
*Cooper,Paul;Jessop, Mike; Moffatt, Frank;Crosland,Susan;ZenecaAgrochemicais, Bracknell,UK Capillary Electrophoresis I Mass Spectrometry for the Routine Analysis of Organic Acids.; Cotton, Nick; Rumbelow, Steve;*Scrivens,Jim;Taylor, Mike; Yates,Hiiary; ICI Research andTechnologyCentre,Middlesbrough, UK Using phosphate and citrate buffers in online CENS: Trials and tribulations; **Craze, Andy; *Bruins,AndriesP; UniversityCentrefor Pharmacy,Groningen,Nederland Direct Analysis of Cellular Components by CEESI-FTICR; *Hofstadler,StevenA.; Severs,JoanneC.; Swanek,FrankD.; Ewing,AndrewG.; Smith,RichardD.; PacificNorthwestNationalLaboratory,Richland,WA Analysis of Fumonisin Bl in Rodent Feed by Capillary Electrophoresis and Confirmation by ESMS; *Holcomb. Manuel;Thompson,Jr., Harold;FDA, NationalCenterfor ToxicologicalResearch, Jefferson,AR Capillary electrophoresis-mass spectrometry of drugs and metabolites in biological matrices; l Lilley, Kim A.; Wheat, ThomasE.; AT1 Separations -Partof Therm0Instruments; Boston,MA Practical Considerations: Analysis of Drug/Xenobiotic Metabolites, Peptides, and Proteins by CE-MS; *Naylor, Stephen;Benson,LindaM.; Tomlinson,Andy J.; Mayo Clinic, Rochester, MN 55905,USA Analysis of Anions by CEMS on a Hybrid Tandem Mass Spectrometer; l Nitowski,Albert J.; Moore,Cohn;Bairley, David W.; **Al-Mudamgha,AreejA.; Robinson,Steve;UniroyalChemicalCompany,Inc. Charge Concentration for High Sensitivity ITMS Detection of Biopolymers; *Ramsey, R.S.; Goeringer,D.E.; McLuckey, S.A.; OakRidgeNationalLaboratory,OakRidgeTN 37831-6365 Analysis of Dyes by CEIMS; l Tetler,Lee;**Cooper,Paul;SheffteidHailamUniversity,Sheffield Attomole Sensitivity Analysis of Recombinant Proteins by Picospray-CE/FTICR-MS; *Valaskovic,GaryA.; Kelleher, Neil, L.; McLafferty, FredW.; CornellUniversity,Ithaca,NY Mass spectrometry of small molecules separated by capillary electrophoresis; *Wheat,Thomas E.; Lilley, Kim A.; AT1 Separations -Partof Therm0Instruments; Boston,MA LIPIDS,
HORMONES
AND BIOMARKERS
Abstracts are arranged alphabetically byfirsr author ThPG ThPG ThPG ThPG ThPG ThPG
of Catechol Estrogen Levels in Breast Tissue; *Cai,Zongwei;Cemy,RonaldL.; Rogan,EleanorG.; Cavalieri,ErcoleL.; Department of Chemistry,Universityof Nebraska-Lincoln HPLC-MS/MS method for detection of benzene metabolites S-phenylmercapturic acid and t,t-muconic acid; *Coleman, Stuart;O’Connor,Ray;Hu, Pei-Feng;Melikian,Assieh;AmericanHealthFoundation,1DanaRoad,Valhalla,NY 10595 Quantification of ceramides and dihydroceramides using FMOC derivatixation and HPLCIAPCI-MS; *Couch,Letha H.; Churchwell,MonaI.; Tolleson,WilliamH.; Howard,PaulC.; Doerge,DanielR.; NationalCenterfor Toxicological Research, FDA, Jefferson,AR 72079 Classification of Bacteria by Gas Chromatography/Mass Spectrometry and Patterv Recognition Analysis; ‘Gharaibeh, AhmadA.; Voorhees,Kent J.; Department of Chemistry,ColoradoSchoolof Mines,Golden,CO80401 Analysis of dolichols and polyprenols and their derivatives by EI, FAB and ES tandem MS; *Griffrths, William; Lundsjo,Anders;Hjertman,Magnus;Wejde,Johan;Larsson, Olie; Sjovall,Jan;KarolinskaInstitute,Stockholm Tandem mass spectrometry of cysteinyl leukotrienes ; *GrifTtths,William;Yang,Yang; Lindgren,JanAke; SjllvaIl, Jan; KarolinskaInstitute,Stockholm The Determination
424 .
44TH
ASMS
CONFERENCE
ON
MASS
SPECTROMETRY
* ThPG ThPG
ThPG ThPG ThPG ThPG ThPG
ThPG ThPG ThPG
Quantitation of Novel C24:x Polyunsaturated Fatty Acids by Negative Chemical Ionization CC/MS; *Hachey, David L.; Sauerwald, Thorsten U.; Nannegari, Vijay; Jensen, Craig L.; Heird, William C; Baylor College of Medicine, Houston, TX 77030 Identification of PAF and acyl-PAF species in human blister fluid in vivo; *Johnson, Christopher A.; Travers, Jeffrey B.; Clay, Keith L.; Zekman, Tami; Morelli, Joseph G.; Murphy, Robert C.; National Jewish Center for Immunology and Respiratory Medicine Identification of Complex Mixtures of Ceramides and Cerebrosides by ESI-MS and ESI-MS/MS; l Kerwin, James; l *Gu, Ming; Watts, Julian; Aebersold, Ruedi; Botany 351330, University of Washington, Seattle, WA 98195 USA Effect of ethanol on incorporation of polyunsaturated fatty acids in C-6 glioma cells; Kim, Hee-Yong; Ma, Yee-Chung; Section of Mass Spectrometry, LMBB, NIAAA, NIH CF-LSI Mass Spectrometric Detection of Phospbolipids in DMSO-Differentiated U937 Cells; *Li, Chun; Wong, Elizabeth; Yergey, James; Merck Frosst Canada Inc., Montreal Searching for Novel Bile Acids in Marsupials with Mass Spectrometry; Pyrek, Jan St.; *Song, Jiangao; University of Kentucky Mass Spectrometry Facility, Lexington, KY and Metabolism of Saponins by Mass Spectrometry: Transformations of Nuatigenin, Sapogenin from Oats; Pyrek, Jan St.; Aggawal, Suressht K.; Goodman, Jack P.; Barboza, Perry; Yang, Pei-Ying; *Song, Jiangao; Jackson, James A.; University of Kentucky Mass Spectrometry Facility, Lexington, KY and MALDI-FT-MS and MS-MS of fully Blocked Glucuronides and Glucosides of Steroids and Bile Acids; *Pyrek, Jan St.; Song, Jiangao; Hadd, Harry E.; University of Kentucky Mass Spectrometry Facility, Lexington, KY Characterization of omega-acyloxy-ceramides by FAB-MS/MS on a four-sector tandem mass spectrometer; *Rubino, Federico Maria; l *Chen, Su; C.E.M.O.C. Lab.for Occupational Toxicology and Allergology, Milan0 (Italy) LC/IonSpray/MS/MS Analysis of Bile Acids; *Sakuma, Takeo; Sanchez, Gabriel; Burton, Lyle; Shushan, Bori; PE Sciex DRUG METABOLISM - QUANTITATIVE STUDIES
Abstracts are arranged alphabetically byfirst author ThPH ThPH ThPH
ThPH
ThPH ThPH ThPH ThPH ThPH ThPH ThPH ThPH ThPH ThPH ThPH ThPH ThPH ThPH
Quantitation of Levorphanol in Human Plasma by LCIMSIMS with APCI Interface; Quantitative determination of CP-93,393 in plasma at trace levels by HPLC/MS/MS; *Avery, Michael; Fouda, Hassan; Pfizer MC Groton, CT Determination of astemizole and desmethylastemixole in human plasma at pg level by HPLC-MS-MS; *Beaudry, Francis; Coutu, Michel; Lessard, Denis; Le Blanc, Yves; Phoenix International, 4625 Dobrin St., St-Laurent (Quebec) H4R 2P7, Canada Development of A Sensitive (LCIMSIMS) Assay for the Antitumor Agent 9-Aminocamptothecin; *Belas, Frank; Arora, Vinod; Goldthwaite, Charles; DeVore, Russell; Blair, Ian; Department of Pharmacology, Vanderbilt University School of Medicine Determination of ZD6169 in Human Plasma by LC-APCYMS/MS: Comparison to a Traditional LC/UV Method; *Bui, Khanh; Gao, Vince; Raybuck, Deborah ; Dyroff, Martin; Birmingham, Bruce; Zeneca Pharmaceuticals Quantitative Analysis of the Vasopressin Antagonist, SR 49059, in Human Plasma Using APCI LC-MS/MS; *Burton, Regina D.; Mummert, Michael; Braithwaite, Frances; Smith, David 1.; Ellames, George J.; Newton, John F.; Wu, Danlin; Clinical Pharmacokinetics & Metab., Sanoti Research Division, Malvem, PA LC-MS/MS Method for Profiling Nicotine and its Metabolites in Biological Fluids; *Byrd, Gary; R. J. Reynolds Tobacco Company, Winston-Salem, NC LCIMSIMS Determination of Ondansetron conjugates in Human Urine; *Campbell, Victoria; Henion, Jack ; **Walsh, John; Advanced BioAnalyticai Services Investigation of 4-Phenylbutyric Acid and its Metabolites using GCMS; *Candelario, Alexander; Stone, Earle; Bach, Stephan; Streeper, Robert; The University of Texas at San Antonio Picogram Determination of a Novel D4 Receptor Antagonist in Human Plasma and Urine by LC-APCI MS-MS; *Chavez-Eng, Cynthia; Constanzer, Marvin; Matuszewski, Bogdan; Merck Research Laboratories, West Point An LC/MS/MS Method for Quantitation of Wellbutrin and its Metabolites in Human Plasma; Dunn, John; Otto, Victoria; Kenney, Kathryn; Smith, Glenn; Long, Joe; Singh, Ashish; *Allsup, Thurman; Glaxo Wellcome Research Triangle Park, NC HPLC-MSiMS Quantification of a S-HT2a Antagonist and Its Metabolite in Rat Brain by Microdialysis; *Heath, Timothy; Scott, Dennis; Hoechst Marion Roussel Analysis of nifedipine (NIF) by LC-MS/MS in plasma to develop new safe clinically NIF formulations; *Kinzig, Martina; RYsing, Guido; SSrgel, Fritz; IBMP - Inst. f. Biomed. and Pharmaceut. Res., NYmberg-Heroldsberg, Germany High pressure CID spectra of isoflavonoids and application to analysis of isoflavones in plasma; *Kirk, Marion; Coward, Lot-i; Barnes, Stephen; University of Alabama at Birmingham, Birmingham, AL 35294 Determination of SCH 51866 in Micropig Plasma via LC-APCUMS/MS; *Korfmacher, Walter; Veals, John; Zhang, Xiping; Watkins, Robert; Cook, John; Tedesco, Richard; Lin, Chin-Chung; Schering-Plough Research Institute, Kenilworth, NJ Determination of 3,4dihydroxyphenylacetic acid (DOPAC) in equine urine by ion-spray LC-MS; *Koupai-Abyazani, Mohammed ; Esaw, Barbara; Laviolette, Barbara; Can Test Ltd., 1523 West 3rd Avenue., Vancouver, B.C., V6J I J8, CANADA Quantitation of Ecteinascidin 743 in Blood by Mass Spectrometry; Lau, Sharon; *Rinehart, Kenneth; University of Illinois, Champaign-Urbana Quantification of Intact Selegiline and Three metabolites in human Plasma Using Electrospray MS/MS; *Li, Qimin; McKay, Gordon; Midha, Kamal; College of Pharmacy & Nutrition, University of Saskatchewan, S7N 5C9 Canada
PRELIMINARY
ThPH ThPH ThPH ThPH ThPH ThPH ThPH ThPH ThPH ThPH ThPH ThPH
ThPI ThPI ThPI ThPI ThPI ThPI ThPI ThPI ThPI ThPI ThPI ThPI ThPI ThPI ThPI ThPI ThPI ThPI
425
PROGRAM
of repamycin: Comparison between curtain-gas and heated capillary API interfaces; * Lim, H.K.; Cinque, T.; Cantone,J.; Gu,H.; Osman,M.; Stroshane, R.; Sisenwine, S.;Chart,K.; Wyeth-AyerstResearch The Quantitation of Cyclosporin A in Dog Blood using Electrospray LC-MS/MS; *Luo, WendyC.; Vekich,Sylvia Y.; RudewicsPatrickJ.; Allergan,Irvine Validation of a LC/MS method for quantifying MDL 188,907 and its metabolite, MDL 105,725, in plasma; l McElvain, James;Perkins,Pamela;Vandiver,Val; Eichmeier,Larry; US BioanalyticsDept.,HoechstMarionRoussel The validation of a quantitative assay for Tirilazad Mesylate and two metabolites in ftve species; *Moore,TheresaA.; Hauer,MichaelJ.; Drug MetabolismResearch, Pharmacia & Upjohn,Inc., Kalamazoo, MI 49001 Determination of Selegiline, Desmethylselegiline and Related Compounds in Human Plasma by LCIMSIMS; *Mulvana, DanielE; Perkins,John;Henion,Jack;**Darttow,John;Bell, Robert;AdvancedBioAnalyticalServices,Ithaca,NY Quantitative Analysis of Taxol in Plasma by Ionspray LC-MS/MS; *Murakami,Stanley;Bethem,Robert;Fukuda,Elaine; ALTA Analytical Laboratory,El DoradoHills,CA 95762 The Determination of the Anti-convulsant 534U87 in Human Plasma by Automated SPE and LC-MS-MS; *Pleasance, Stephen;Biddlecombe, RobertA.; Jones,AnneE.; Eaves,C. Jane;GlaxoWellcome Quantitative Analysis of the NKl Receptor Antagonist, SR 140333, in Human Plasma Using LC-MS/MS; *Price, Piper I.; Buhrman,DeborahL.; Burton,ReginaD.; Simpson,Heidi;Herbert,JohnM.; Ellames,GeorgeJ.; Newton,JohnF.; Drozd, Marion L.; ClinicalPharmacokinetics 8cMetab.,SanofiResearch Division,Malvem,PA Quantitation of Muscle Relaxants in Plasma using HPLC/Tandem Mass Spectrometry; Rindgen,Diane;*Mar-zilli, Lisa; Martyn, Jeevendra;Vouros,Paul;Northeastern University,BamettInstitute,Boston,MA 02115 Sensitive measurement of erythromycin A and its byproducts in tablets and plasma using LC-MS/MS; *RYsing,Guido; Kinzig, Martina;Haag,Annin; SBrgel,Fritz; IBMP - Inst.f. Biomed.andPharmaceut. Res.,NYmberg-Heroldsberg, Germany Quantification of CP-116,517 and its Metabolite CP-114,099 from Human Plasma by HPLClESI /MS/MS; *Schneider, Richard;Hoffmaster,Keith; Fouda,Hassan; CentralResearch Division,Pfizer Inc, Groton,CT 06340 Flow-Injection ES1 (MS/MS) of PCV-TP & ACV-TP in Extracts of a Herpesvirus-Infected Neural Cell line; l Smymis, Elie, M.; Sacks,Stephen,L.; Burton,Roland;Abbott, Frank;Universityof BritishColumbiaVancouver,Canada LASER DESORPTION - INSTRUMENTATION Abstracts are arranged alphabetically byfirst author Optically Isolated Microchannel Plate Detector Module for High Voltage Postacceleration of MALDI Ion; *Benner,W. Henry;l ;Hom, David; LawrenceBerkeleyNationalLaboratory A Bench-Top MALDI-ToF for the Rapid Sequencing of Peptides and Proteins; Bowdler,AndrewR, Dingley,DavidC ; *Humphrey,Paul; KratosAnalytical, BartonDockRoad,Manchester,.M41 7LD, UK. Enhancement of MALDI-TOF MS and MS/MS performance using Delayed Extraction; *Brown,J. M.; Bateman, R. H.; Critchley,W. G.; Hoyes,J. B.; Kingston,R. G.; VG Organic,Manchester, M23 9LZ, UK Delayed Extraction and Laser Desorption: Time-lag Focusing and Beyond.; *Colby, StevenM.; ScientificInstrument Services,Inc. Post-Source Decay Without Scanning the Reflectron: Applications to Biomolecules.; *Cordero,M.M.; Woods,AS.; Comish,T.J.; Cotter,R.J.;Pharmacology, JohnsHopkinsUniversityMedicalSchool,BaltimoreMD MALDI/MS and the Aging Process: Oxidative Protein Damage; *Deterding,Leesa; Barr, David;Mason,Ronald;Tomer, Kenneth;NIEHS, Research TrianglePark,NC Fragmentation of phosphorylated peptides: MALDI on Time-of-Flight and FTMS Analyzers; *Gillece-Castro, Beth; St&, John;Genentech, Inc. SouthSanFrancisco,CA MALDI TOF MS Analysis of Glycoproteins Using Delayed Extraction; *Karas,Michael;Bahr,Ute; l *TsarbopouIos, Anthony; Prarnanik,BirendraN.; JW Goethe-Univ.,Div. for Instrum.Analyt. Chem.,60590Frankfurt,Germany Sequence Analysis of Modified Oligonucleotides by MALDI Mass Spectrometry; Kosaka,Toshiyuki;*Kinoshita,Takeshi; Takazawa,Tomoko;Nakamura,Takemichi;Koizumi,Makoto; Hotoda,Hitoshi;AnalyticalandMetabolicResearch Laboratories, SankyoCo., Ltd., Tokyo. Characterization of protein glycosylation by post source decay and exoglycosidase digestion; *Krogh, Thomas N.; Mjrtz, Ejvind; Mirgorodskaia,Ekaterina;Roepstorff,Peter;H&up, Peter;Dept.of MolecularBiology, OdenseUniversity,DK-5230 OdenseM, Denmark Delayed Ion Extraction for the Analysis of Metastable Fragmentation in MALDEMS; *Luedemann, Hans-Christian; Stahl-Zeng,Jianru;Hillenkamp,Franz;Institutefor MedicalPhysicsandBiophysics,Universityof Muenster Characterization of Neutral Products in the Laser Photolysis of Monolayer Organosiloxane Films; l McElvany, Stephen; Friedli,Andrienne;Dulcey,Charles;Holliman,Christopher; NavalResearch Laboratory,Washington, D.C. Use of Immobilized Enzymes and Delayed Extraction MALDI-TOF for Protein Characterization; *Patterson,Dale;Tarr, George;Hines,Wade;Vestal,Marvin; Martin, Stephen;PerSeptiveBiosystems, Inc., Framingham, MA Quantitetion
Comparison
of CID and PSD Data Obtained from Tryptic
Peptides Using Delayed Extraction
MALDI-TOF
MS;
*Peltier,John;Waddell,Keith; Mark, J.; Falick,Arnold; PerSeptiveBiosystems, Inc. Framingham MA 01701 Examination Of The Use Of MALDI In-Source Decay For Sequencing Peptides; *Reiber,Duane;Brown,Robert; Weinberger,Scot; Komfeld,Rich; Kenny,James; UtahStateUniversity,Logan,UT 84322-0300 DavidH.; Edmondson, Ricky D. ; Texas Optimization of the Parameters Effecting MALDI Mass Resolution ; *Russell, A&M University,CollegeStation Characterization of recombinant annexin 1 domain 2 by MALDEMS, mass mapping and PSD; *Shen,Tun-Li; Li, Yue; Yan.Hong-Gao;Gage,DouglasA.; Dept.of Biochemistry,MichiganStateUniversity,EastLansing,MI 48824 Disultlde Bonding in Biologically Active Peptideskoteins: A MALDI FT-ICR I MS Analysis; +Solouki,Touradj; Emmett,Mark, R.; Guan,Shenheng; Marshall,Alan G.; NationalHighMagneticFieldLab, FloridaStateU., Tallahassee FL
426
ThPl ThPI ThPI
44TH
ASMS
CONFERENCE
ON
MASS
SPECTROMETRY
Biopolymer sequencing by MALDI-TOF MS; *Suckau, Detlev; KSster, Claus; Holle, Armin; Bruker-Franzen Analytik GmbH, Bremen Accurate Mass Measurements Using Delayed Extraction MALDI Time-of-Flight Mass Spectrometry; *Takach, Edward; Patterson, Dale; Hines, Wade; Juhasz, Peter; Lee, Richard; Vestal, Marvin; Martin, Stephen; PerSeptive Biosystems, Inc., Framingham, MA Structural Analysis of Peptidoglycans by MALDI-MS and PSD; *Xu, Naxing; Huang, Zhi-Heng; Watson, J. Throck; Gage, Douglas A.; **de Jonge, B.L.M. ; Severin, Anatoly; Tomasz, Alexander; Dept. of Biochemistry, Michigan State University, East Lansing, MI 48824 LASER DESORF’TION - APPLICATIONS
Abstracts are arranged alphabetically byfirst author ThPJ ThPJ ThPJ ThPJ
ThPJ ThPJ ThPJ ThPJ ThPJ ThPJ ThPJ ThPJ ThPJ ThPJ ThPJ ThPJ ThPJ ThPJ ThPJ ThPJ
Fragmentation of Peutides Generated by MALDlI in a Linear Time-of-Flight Mass Spectrometer; Amft, Matthias; Finsierer, Roland; Da&m, Monika; *Grotemeyer, Jtirgen; Institut fhr Physikalische Chemie, Universitat Wthzburg Identification of pheromone binding proteins by MALDI and ES1 after HPLC and native-PAGE; *Blais, Jean-Claude; **Nagnan Meillour, Patricia; Bolbach, Gerard; Tabef Jean-Claude; Universit Pierre et Marie Curie - Paris MALDI-TOFMS investigation of peptide-protein interactions, * *Bolbach, G rard; Blais, Jean-Claude; Brunot, Alain; **Girault, Sophie; Lavielle, Solange; Chassaing, G rard; Sagan, Sandrine; Universit P&M Curie, CNRS EP 103, PARIS Glycoprotein Analysis via MALDI TOF-MS and HPCE Coupled with off-line MALDI TOF-MS; l Chapel, John; Hancock, William; Udiavar, Sharmila; **Swedberg, Sally; Biomeasurements Group, Hewlett-Packard Laboratories, Palo Alto, CA 94304 Micro-Spot MALDI for Ultrasensitive Detection of Nanoscale Samples; +Golding, Rafael; Whittal, Randy; Li, Liang; Department of Chemistry, University of Alberta MALDI-TOMMS for the Analysis of Potential Blood Substitutes; *Gu, Xiaomei; Kondubhotla, Sujatha; Aldridge, Allison; Chiarelli, Paul; Olsen, Kenneth; Depatment of Chemistry, Loyola University-Chicago, Chicago, IL 60626 TLCMALDI: principles and applications.; *Gusev, Arkady I.; Mehl, John T.; Wilkinson, William R.; Nicola, Anthony J.; Vasseur, Olivier J. ; Hercules, David M.; Department of Chemsitry, Vanderbilt University, Nashville, TN 37235 External Ion Injection for the HPLC-Liquid MALDI in an Ion trap/TOF Mass; *He, Ling; Chen, Xin; Lubman, David M.; Chemistry Dept. University of Michigan Ann Arbor, MI 48109-1055 MALDI: Preserved solution/solid-phase peptide-metal ion interactions without gas-phase interactions; l Homshaw, Martin; Hutchens, T.William; University of California, Davis MALDEMS of peptides and proteins off streptavidine-coated magnetic beads; Larsen, Martin Roessel; l Nordhoff, Eckhard; Gerdes, Kenn; Roepstorff, Peter; Department of Molecular Biology, University of Odense, Denmark Analysis of a Pentameric Complex of Cholera Toxin B-subunit by MALDI-TOF and Electrospray MS; l *Mandel, Friedrich; Dragovic, Marina; *Raverdino, Vittorio; Analytical lab Hewlett-Packard, rue Veyrot 39, Geneva, Switzerland Mass spectrometric characterization of glycoproteins separated by gel electrophoresis.; *M,$z, Ejvind; **Krogh, Thomas N.; H&up, Peter; RoepstorIf, Peter; Dept. of Molecular Biology, Odense University, DK-5230 Odense M, Denmark A Novel Laser Microprobe QITMS for Imaging of Drug Compounds in Intact Biological Tissue; *Reddick, Christopher D.; Yost, R.A.; University of Florida Experiences in sample preparation for MALDI from the Protein Research Group at the Odense University; *Roepstorff, Peter; Nielsen, Henrik R.; Larsen, Martin R.; Haebel, Sophie; Jensen, Charlotte; **Palm, Lisbeth; Krogh , Thomas; Mirgorodskaya, Ekatarina; Department of Molecular Biology, Odense University, Denmark Examination of Approaches for Application of MALDI as an On-Line Biological Detection Technique; *Steadman, Jhobe; Roser, Dennis; **Long, Randolph; GeoCenters, Fort Washington, MD Semi-Automated Sample Analysis Using Liquid ChromatographyMALDI Mass Spectrometry; *Stevenson, Tracy I.; Loo, Joseph A.; Parke-Davis Pharmaceutical Research, Ann Arbor, MI MALDI MS of Proteins Adsorbed to Modified and Unmodified Polymer Substrates; *Walker, Angela K.; Kinsel, Gary R.; Timmons, Richard B.; Wang, Y.-S.; Dept. of Chemistry, The University of Texas at Arlington, Arlington, TX Use of Synthetic Membranes to Prepare Proteins, Oligonucleotides, and Digests for MALDI-TOF Analysis; * Worrall, Timothy A.; Woods, Amina S.; Cotter, Robert J.; Pharmacology, Johns Hopkins University Medical School, Baltimore MD Mercaptobenxothiazoles: New Matrices for Laser Desorption Ionization Mass Spectrometry; *Xu, Naxing; Huang, ZhiHeng; Gage, Douglas; Watson, J. Throck; Dept. of Biochemistry, Michigan State University, East Lansing, MI 48824 In Vivo Study of the Oxidation of Substance P in Rat Brain by MicrodialysisMALDI MS; *Zhang, Hong; Caprioli, Richard; University of Texas Medical School, Houston, Texas 77030 SPRAY IONIZATION - APPLICATIONS
Abstracts are arranged alphabetically byfirst author ThPK ThPK ThPK ThPK ThPK
Characterisation of water soluble Rotaxanes by Electrospray Ionisation MassSpectrometry.; Anderson, Harry; Andesrson, Sally; *Aplin, Robin; The Dyson Perrins Laboratory,Oxford University,Oxford, UK. OX1 3QY The Determination of Protein Modifications by Precursor Ion Scans of Proteolytic Digest Mixtures; *Bourell, James; Stults, John; Genentech, Inc., South San Francisco, CA 94080 Probing the Oligomeric Structure of an Enxyme by ESI-TOFMS; *Fitzgerald, Michael, C.; Chemushevich, Igor; Standing, Kenneth, G.*I-2; Whitman, Christian, P.; Kent, Stephen, B.*I-2; The Scripps Research Institute, La Jolla, CA Analysis of Cobalt Coordinated High Mannose Oligomers using Ion Trap Mass Spectrometry; **Gale, David C.; Sweeney, Matt, J.; Kohler, Martin; l Leary, Julie A.; College of Chemistry. University of California, Berkeley, CA 94720 Ternary complexes of tripeptides with copper(H) and diimine in the gas phase.; Gatlin, Christine; Turecek , Frantisek; l Vaisar, Tomas; Molecumetics Ltd* and Dept. of Chemistry, University of Washington
PRELIMINARY
ThPK ThPK ThPK
ThPK ThPK ThPK ThPK ThPK ThPK ThPK ThPK ThPK ThPK ThPK ThPK
ThPK
ThPK ThPK ThPK ThPK ThPK
PROGRAM
427
Negative Ion Electrospray Mass Spectra of Fullerene Derivatives; *Hailer, Ivan; Mirza, Urooj A.; Chait, Brian T.; Tokuyama, H.; Strongin, R. M.; Smith, Amos B., III; The Rockefeller University, New York, NY 10021 Direct Quantitation of Methyl Succinate by Electrospray Negative Ion Tandem Mass Spectrometry; *Ketcha, Marcia M.; Strife, Robert J.; The Procter and Gamble Co. ‘Noncovalent Complexes of Citrate Synthase and NADH.; *Krutchinsky, Andrew N.; **Ayed, Ayeda; Chemushevich, Igor V. [ 11; Ens, Werner E. [ 11; Duckworth , Harry E. [2]; Standing , Kenneth G. [I]; University of Manitoba, Physics Dept., Winnipeg Manitoba Canada R3T 2N2 Characterization and formation studies of synthetic supramolecular complexes by ESMS; *Leize, Emmanuelle; DuPont, Annick; Marquis-Rigault, Annie; Baxter, Paul; Lehn, Jean-Marie; Van Dorsselaer, Alain; Laboratoire de Spectrom trie de Masse Bio-Organique - Strasbourg (France) Analysis of trypsin-inhibitor complexes by electrospraylmass spectrometry; *Lin, Baiwei; Traina, Joe; Liang, Amy; Light, David; Berlex Biosciences ESI-MS Characterization of Zinc Ejection from WV-1 Nucleocapsid Protein by Disulfide Benxamides; *Loo, Joseph A.; Parke-Davis Pharmaceutical Research, Ann Arbor, MI Electrospray Ionization Mass Spectra of Carbocyanine Dyes Used as Molecular Probes; l Melnyk, Michael; Busch, Kenneth; Bartlett, Michael; School of Chemistry & Biochemistry, Georgia Inst. of Technology, Atlanta GA Additive Enhancement for Electrospray lonixation of Nitrated Explosives; *Miller, Mark L.; Leibowitz, Jeff; Martz, Roger; FBI Laboratory, FBI Academy, Quantico, VA 22135 Optimization of ES1 Conditions for Detection of Non-Covalent Complexes of Calmodulin with Peptides; *Nemirovskiy, Olga; Gross, Michael; Ramanathan, Ragulan; Chemistry Department, Washington University, St. Louis, MO 63 130 Analyses of Coenxyme B12 Derivatives and Complexes with Non-Covalent Bondings by using ESI-MS; *Peilascio, Bernhard C.; Pfammatter, Michael J.; Schlunegger, Urs P. ; Institute of Organic Chemistry, University of Bern, CH-3012 Bern Detection of glycosylated and phosphorylated peptides by LC-MS using API-CID and in-source CID; *Seipelt, C. Thomas; Caldwell, Brenda E.; Pound, Vickie L.; Abbott Laboratories - Ross Products Division Purity of Polysulfated Materials Determined by Negative ESUMS; *Siegel, Marshall; Tabei, Keiko; **Kagan, Michael; Wyeth-Ayerst Research, Pearl River, NY Regulation of Multimer Formation in API-MS; *Stefansson, Morgan; SjSberg, Per J. R.; Bylund, Dan; Markides, Karin E.; Dept. of Analytical Chemistry, Uppsala University Inclusion complexes versus electrostatic adducts in electrospray and capillary zone electrophoresis; *Suter, Marc J.-F.; Kanz, Carlo; Giger, Walter; Kohler, Hans Peter; Swiss Federal Institute for Environmental Science and Technology (EAWAG) An Investigation of Cyclodextrin-Drug Complexes: True Complexes or Electrostatic Adducts?; ‘Visentini, Josie; Bertrand, Michel; **Gagnon, Helene; Rousseau, Caroline; Winters, Conrad; Merck Frosst Centre for Therapeutic Research, Kirkland, Quebec Determination the unstable intermediates from organic reactions by low temperature ESBMS and FABIMS; Wang, Chin-Hsiung; Chei, Hsing-Long; *Shies, Jentaie; Dept. of Chemistry, National SunYat-sen University, Kaohsiung, Taiwan,804 The Study of the structure of the ligands to the folding of protein by ESVMS; Wang, Yu-Ting; *Shies, Jentaie; Dept. of Chemistry, National Sun Yat-sen University, Kaohsiung, Taiwan, 804 Cyclic nucleotide quantitation in biological samples using IS-HPLC coupled to ES-MSMS.; l Witters, Erwin; Van Dongen, Walter; l *Esmans, Eddy; Van Onckeien, Harry; Department of Biology, University of Antwerp (U.I.A.), Antwerp Use of ESI-FTICR-MS to rapidly detect taxonomically significant double stranded PCR products.; l Wunschel, David; **Muddiman, David; Bruce, James; Fox, Karen; Fox, Alvin; Smith, Richard; University of South Carolina, School of Medicine, Columbia, South Carolina Metal Ion Flux in Metalloprotein-Drug Reactions; *Zaia, Joseph; Fabris, Daniele; Fenselau, Catherine; University of Maryland, Baltimore County Protein Fragmentation in ES1 Induced by the Auxiliary Gas; Analysis of the Data by MaxEnt; ‘Zhang, X. Kate; Dusky (dec.), Robert C.; Derua, Rita; Ferrige, Anthony G.; Fales, Henry M.; National Heart, Lung, and Blood Institute, NIH,Bethesda, MD
AFFINITY-BASED SEPARATION AND INTERACTIONS Abstracts are arranged alphabetically byfirst author ThPL ThPL ThPL ThPL ThPL ThPL ThPL
Mass spectrometric characterization of the active and inactive form of Ras protein; *Akashi, Satoko; Shirouzu, Mikako; **Yokoyama, Shigeyuki; Takio, Koji; The Institite of Physical and Chemical Research (RIKEN) Selective Detection of AldehydelPeptide Adducts Using Afftnity Extraction and Tandem MS Screening; ‘Bolgar, Mark; Gaskeli, Simon; The Michael Barber Centre for Mass Spectrometry, UMIST, Manchester New Chemistries for Probe Afftnity-Mass Spectrometry; l Brockman, Adam; Orlando, Ron; CCRC, University of Georgia, Athens, GA, 30602 Bioaffbtity Characterization MS of Phosphopeptide Binding to Human Src SH2 Domain; *Bruce, James E.; **Carr, Steven A.; Anderson, Gordon A.; Pasa-Tolic, Ljiljana; Hofstadler, Steven A.; Smith, Richard D.; Pacific Northwest National Laboratory, Richland, WA Determination of &agonists in Bovine Urine by lmmunoaffbtity Extraction-LCYLCIMSIMS; l Cai, Jenny; Henion, Jack; Cornell University Probing non-covalent complexes of tyrosyl phosphopeptides and an SH2 domain by ES1 MS; l Chung, Evonne; Mulhem, Terry; Morton, Craig; Robinson, Carol; Oxford Centre for Molecular Sciences Epitope mappings of maillard reaction products using LCIESIMS; *Hirayama, Kazuo; Tagami, Uno; Yamada, Naoyuki; Yuji, Reiko; Kazuyoshi, Noguchi; l *Toshimitsu, Niwa; Central Research Laboratories, AJMOMOTO Co., Inc.
428 .
44TH
ASMS
CONFERENCE
ON
MASS
SPECTROMETRY
* ThPL ThPL ThPL ThPL ThPL
ThPL ThPL ThPL ThPL ThPL ThPL ThPL ThPL ThPL
ThPL ThPL
Continuous Epitope Mapping by On-line Capillary Electrophoresis - ES1 Mass Spectrometry; Lyubarskaya, Yelena; l Dunayevskiy, Yuriy M.; Vouros, Paul; Karger, Barry L.; The Bamett Institute, Northeastern University, Boston, MA Protein epitope identification using limited proteolysis of immune complexes and mass spectrometry; *Macht, Marcus; **KUrzinger, Konrad; Przybylski, Michael; University of Konstanz, PO Box 5560 M 732,78434 Konstanz, Germany Determination of the sites of interaction between the formyl peptide receptor and its ligand.; *Mills, John; Bamidge, David; Dratz, Edward; Jesaitis, Algiidas; Montana State University, Bozeman MT Characterization of the pore-forming aerolysin toxin non-covalent complex by MALDI-TOF MS; l Moniatte, Marc; van der Goat, F. Gisou; Buckley, J. Tom; Pattus, Franc; Van Dorsselaer, Alain; Laboratoire de Spectrom trie de Masse BioOrganique, ULP, Strasbourg Identification of a Noncovalent Trimer of Catiflsh Roe Lectin by Centrifugation and MassSpectrometry; *Murayama, Kimie; Taka, Hikari; Kaga, Naoko; Shindo, Noriko; Hosono, Masahiro; Nitta, Kazuo; Cent. Lab. of Med. Sci. Juntendo Univ.Sch. of Med. Tokyo Japan Structural Immunology by MALDUMS: Epitope Determination on AIDS Related Proteins; Parker, Carol; Trojak, Sonja; *Tamer, Kenneth; National Institute of Environmental Health Sciences Study of non-covalent enzyme/cofactor and enxymelinhibitors complexes by ESI-MS; Potier, Noelle; Barth, Patrick; Trisch, Denis; Biellmann, Jean-Francois; *Van Dorsselaer, Alain; Laboratoire de spectrometrie de masse bio-organique Probing the nature of non-covalent protein ligand interactions; *Robinson, Carol ; Chung , Evonne; Kragelund, Birthe; Knudsen, Jens; Dobson, Christopher; Oxford Centre for Molecular Sciences Study of Non-covalent Interactions and H/D Exchange using Micro Electrospray; Robinson, Carol; **Jarvis, Stuart; l Chung, Evonne; Hughes, Christopher; Green, Brian; Oxford Centre for Molecular Sciences, Oxford, UK. Studying Drug Binding to the Noncovalent Tat Peptide-TAR RNA Complex by ESI-MS; *Sannes, Kristin A.; Mei, Houng-Yau; Ma&, David; Loo, Joseph A.; Parke-Davis Pharmaceutical Research, Ann Arbor, Ml Interaction studies combining plasmon resonance in a BIAcore instrument with MALDI- and nano ESI-MS; SSnksen , Carsten P; * * Jansson , . . .sten; Stenberg, Esa; l Roepstorff, Peter; Department of Molecular Biology, University of Odense, Denmark MALDI Mass Tracer Methods Based on the Avidin-Biotin Interaction; *Schriemer, David C.; Li, Liang; University of Alberta, Edmonton, Alberta, Canada Ff ICR Investigation of Supramolecular Propellers of Chiral Dialkyltartrate Trimers; l Winkler, F. Johann; Denisov, Edward V.; Medina, Ramiro; Schustrjakov, Valerij; Vinogradov, Pave1 S.; Nikolaev, Eugene N.; Institut f. Chemie, Techn. Univ. Muenchen, D-85350 Freising, Germany Comparison of Solution and Gas Phase Binding Affinities of Inhibitors to Carbonic Anhydrase; *Wu, Qinyuan; Gao, Jinming; Bruce, James E.; Sigal, George B.; Whitesides, GeorgeM.; Smith, Richard D.; Pacific Northwest National Laboratory *Yip, Tai-Tung; Hutchens, T. William; Dept of Food Affinity Mass Spectrometry for the Study of Signal Transduction; Sci & Tech, U of California, Davis, CA95616 MALDYtimesf-flight MS analyses of antigens after immunoafllnity extraction from whole cell lysates; Yu, Lu; **Brookman, Jayne L.; *Gaskell, Simon J.; Michael Barber Centre for Mass Spectrometry, UMIST, Manchester, U.K. PROTEINS AND PEPTIDES
Abstracts are arranged alphabeticaMybyjirst author ThPM ThPM ThPM ThPM ThPM ThPM ThPM ThPM ThPM ThPM ThPM ThPM ThPM
Beta-Endorphin-Containing Proteins in Human Pituitary; l Becklin, Robert ; Yan, Lin : Chu, Jasper; Tseng, Jih-Lie ; Desiderio, Dominic; Stout MS Lab. University of Tenessee,-Memphis. Locating hemes in cytochrome b using MALDI-TOF mass spectrometry; *Bamidge, David; Sunner, Jan; Dra& Edward; Mills, John; Jesaitis, Algirdas; Montana State University Investigation of the Interactions Between 4-Hydroxynonenal and Lysine Residues of Proteins; *Bolgar, Mark; Gaskell, Simon; The Michael Barber Centre for Mass Spectrometry, UMIST, Manchester Determination of oxidation sites in alpha crystallin by ESI-MS/MS; *Busman, Mark; Finley, Eric L.; **Dillon, Jim; Crouch, Rosalie K.; Schey, Kevin L.; Dept. of Pharmacology, Medical Univ. of South Carolina, Charleston, SC Direct Characterization of Proteins from Organisms with Small Genomes; * Carmack, Edwin; Hays, Lara; Link, Andrew; Yates, John R.; University of Washington, Seattle, WA Investigation of binding of SSB to DNA by competitive labeling and mass spectrometry; l Chen, Jiwen; Griep , Mark A.; Smith, David L.; Department of Chemistry, University of Nebraska, Lincoln, NE 68588 Detection of the specific binding site between NM23H2 and human c-myc gene by LCIMS; *Chen, Yajuan; Qian, Mark G.; Bai, Jian; Zheng, Kefei; Chang, Christina L.; Lubman, David M.; The Univeristy of Michgain, Ann Arbor A Study of Possible Breast Cancer Markers Using ZD-PAGE Combined with Tandem Mass Spectrometry; *Clarke, Nigel J.; Tomlinson, Andy J.; Naylor, Stephen; Mayo Clinic, Rochester, MN 55905, USA Analysis of purified human serum albumin by electrospray ionixation mass spqctrometry; *Cyr, Terry Donald; Girard, Michel; Bietlot, Hemi; Health Protection Branch, Drugs Directorate, Bureau of Drug Research The Identification of the Disulflde Bonds in the Circulins, a Group of Anti-HIV Circular Peptides; *Derua, Rita; Gus&on, Kirk; Hallock, Yali; Pannell, Lewis; Laboratory of Analytical Chemistry, NIDDK, NIH, Bethesda MD 20892-0805 Sequencing of Glucokinase from Bacillus stearothermophilus by Tandem ESI-FTICRMS; *Dufresne, Craig; Wood, Troy; State University of New York at Buffalo, Buffalo, NY Characterixation of BSA based immunogens by MALDI and ES1 mass spectrometry; l Gebler, John; Adamczyk, Maciej; Mattingly, Phillip; Abbott Laboratories, Abbott Park, IL The amino acid sequence of a copper-binding metallothionein isolated from Helix pomatia snails; *Gehrig, Peter; Hunxiker, Peter; **Berger, Burkhard; Dallinger, Reinhard, Biochemisches Institut der Universitat Zurich, Zurich, Switzerland
PRELLMINARY
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Identification of a Murine Colorectal Tumor Antigen by Tandem Mass Spectrometry; *Gulden, Pamela; Huang, Alex; Shabanowitz, Jeffrey; Wang, Wei; Engelhard. Victor; Jaffee, Elizabeth; Pardoll, Drew; Hunt, Donald; University of Virginia, Charlottesville, VA Identification of an Allosntigen by Tandem Mass Spectrometry; *GuIden, Pamela; Wang, Wei; Shabanowitz., Jeffrey; Engelhard, Victor; Hum, Donald; University of Virginia, Charlottesville, VA Investigation of Lens Proteins with High Cysteine Content; *Hanson, Stacy R.A.; Smith, Jean B.; Smith, David L.; Department of Chemistry, University of Nebraska-Lincoln Location of Oxidized Residues in Bovine alpha-Crystallins by HPLC/ESI/MS and CF-FAB MS/MS; l Jiang, Xiangyu; Smith, Jean B.; Smith, David L.; Abraham, E. C.; Department of Chemistry, University of Nebraska-Lincoln, Lincoln, NE 68588 Proteolytic Processing of a 44mer Ovalbumin Peptide by the Murine Protensome; *King, Gina M.; Niedermann, Gabi; Shabanowitz, Jeffrey; Hunt, Donald F.; Eichmann, Klaus; University of Virginia, Charlottesville, VA Characterization of insect diuretic hormone proteolysis using RP-HPLCIESI-MS; *Li, Hong; Wang, Houle; Schegg, Kathy; Schooley, David; University of Nevada, Reno, NV 89557 Application of on-line CE-ESI-IT/TOF in the analysis of Variant Hemoglobin; *Li, Michael, X.; Wu, Jingtao; Liu, Lin; He, Ling; Lubman, David M.; Univ. of Michigan Isolation and Structural Determination of Modified Human Alpha-Crystallins by IEX, LC-MS and MS/MS; l Lin, Peiping; Smith, Jean; Smith, David; Department of Chemistry, University of Nebraska-Lincoln, Lincoln, NE 68588 ESI-MS evaluation of post-translational modifications to histone proteins through the cell cycle; *Lipton, Mary S. Weir; Springer, David L.; Metting, Noelle F.; Edmonds, Charles G.; Pacific Northwest National Laboratory Fast Detection of Peroxisomal Protein Mutants by CEIMS; *Liu, Lin; Li, Michael, X.; Wu, Jingtao; Lin, Yan; Orlson, Laura; Lubman, David M.; University of Michigan, Dept. of Chem. Identification of in vivo modifications of water insoluble human lens alpha-crystallins; *Lund, Anders L.; Smith, Jean B.; Smith, David L.; Department of Chemistry, University of Nebraska, Lincoln, NE 68588-0304 Tandem Mass Spectrometry: Analysis of Endogenous Peptides Presented by MHC Class II I-Ab Molecules; l McCormick, Ashley; DeRoos, Paul; Grubin, Cathy; Rudensky, Alexander; Yates, John; University of Washington The human male-specific histocompatibility antigen H-Y is derived from the SMCY protein; *Meadows, Leslie; Wang, Wei; den Haan, Joke; Sherman, Nicholas; Shabanowitz, Jeffrey; Hunt, Donald; Goulmy, Els; Engelhard, Victor; University of Virginia Glutathione-S-Transferase Heterogeneity in Human Tissue Analyzed by ES&MS; *Nieves, Edward; Rowe, Jonathan D.; Listowsky, Irving; Albert Einstein College of Medicine Capillary LCIITIreTOF MS for Structural Confirmation of Three Recombinant Protein Isoforms; l Qian, Mark G.; Zheng, Kefei; Chen, Yajuan; Chang, Christina L.; Lubman, David M.; The University of Michigan, Ann Arbor Structural studies of HIV related proteins using MALDIMS; *Qian, Xiao-Hong; Parker, Carol; Bienstock, Rachelle; Jeyarajah, Shanthini; Tomer, Kenneth; National Institute of Environmental Health Sciences Electrospray Mass Spectrometry of the Human SlOO Proteins Calgranulin A, B and C.; *Raftery, Mark; Geczy, Carolyn; Immunology Group, The Heart Research Institute. Covalent modification of rho protein by the antibiotic, bicyclomycin; Riba, Isabel; *GaskelI, Simon J ; Park, Hyeunggeun; Zhang, Xiangdong; Widger, William R; **Kahn, Harold; Michael Barber Centre for Mass Spectrometry, UMIST, Manchester, U.K. Mass Spectrometric Analysis of the Lens Membrane Protein MP26; l Schey, Kevin L.; Fowler, John G.; **Dillon, Jim; Crouch, Rosalie K.; Dept. of Pharmacology, Medical Univ. of South Carolina, Charleston, SC Analysis of Proteins in the 80s Ribosomal Complex of S. cerevisiae by Mass Spectrometry; l Schieltz, David M.; Eng, Jimmy K.; Yates III, John R.; University of Washington, Seattle, WA Characterization of Covalent Modifications in a Viral Protease by ESI-MS and MALDI-TOFMS; l Sheeley, Douglas; Wright, Lois; Furtine, Eric; Moyer, Mary; Glaxo Wellcome Research Laboratories, RTP, NC 27709 Characterization of Human Cytomegalovirus Protease (28 kDa) and Inhibitors by ESIMS; *Siegel, Marshall; Tabei, Keiko; Bebemitx, Geraldine; Hulmes, Jeffrey; Ding, Wei-Dong; Baum, Ellen; Wyeth-Ayerst Research, Pearl River, NY Identification of a Poliovirus RNA Translation Protein Using Data-Controlled LCIMSIMS; l Swiderek, Kristine M.; Blyn, Lawrence B.; Stahl, Douglas C.; Beckman Research Institute of the City of Hope, Duarte, CA 91010 Mass Spectrometric Analysis of the Sfp Cell-Derived Interleukin-5 Receptor; l Tsarbopoulos, Anthony; Prongay, Andrew; Baldwin, Sam; Kumarasamy, Ramasamy; Pramanik, Birendra; Le, Hung V.; Karas, Michael; Hillenkamp, Franz; Schering-Plough Research Institute, Kenilworth, NJ 07033-0539 Characterization of CMP-NeuAc Synthetase and its CTP-Binding Site by ES1 and MALDI-MS; Tullius, Michael; *Gibson, Bradford; **Munson, Robert; University of California, San Francisco, CA 94143-0446 Characterisation of the Proteolytic Sites of Proteases Isolated From P. gingivalis WSO; *U., S.; Sutton, C. W.; **Rangarrjan, M.; Therm0 BioAnaIysis Ltd., Hemel Hempstead, UK Formation and Stabilization of MHC Class II-Peptide Complexes: Results of a MALDI Study; l Vidavsky, Ilan; Whitehill, Andy B.; Gross, Michael L.; Nelson, Chris A.; Unanue, Emil R.; Department of Chemistry, Washington University, St. Louis, MO 63 130 Characterixation of Low Molecular Weight Chromium Binding Substance by MALDI FT-ICR MS; *Vining, Bryan; Li, Guo-Zhong; Solouki, Touradj; Guan , Shenheng; Marshall, Alan; Vincent, John; National High Magnetic Field Lab, Florida State Univ., Tallahassee, FL Identification of target antigens in Multiple Sclerosis; *Walker, Carthene B.; Shabanowitq Jeffrey; Hunt, Donald F.; Snoke, Ken; Sette, Alex; University of Virginia, Department of Chemistry, Charlottesville, VA 22901
430
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Site of Acrylodan Adduct Formation with Fatty Acid Binding Protein and FK506 Binding Protein; *Williamson, Brian L.; Tomlinson, Andy J.; Holmes, Michael W.; Kurian, Elizabeth ; Silva, Norberto; Prendergast, Franklyn G.; Naylor, Stephen; Mayo Clinic, Rochester, MN 55905, USA Rat kidney glutathione S-transfernse 1 subunits have C-terminal truncations; Yeh, Homg-I; Lee, Jing-Yu; Tsai, Shu-Ping ; Hsieh, Cheng-Hsilin; *Tam, Ming F.; Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan, ROC