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from our files CLINICAL PHARMACOKINETICS OF THEOPHYLLINE Pharmacokinetics in drug therapy, ii: application of clinical pharmacokinetics in the assessment of theophylline therapy. Floyd, R.A. et al. American Journal of Hospital Pharmacy 34: 402 (1977) Theophylline blood levels after administration of Euphyllin retard. Ahrens, J. Deutsche Medizinische Wochenschrift 102: 482 (1977) Absolute bioavailability of oral theophylline. Hendeles, L. et al. American Journal of Hospital Pharmacy 34: 525(1977) Theophylline poisoning. Vaucher, Y. et al. Journal of Pediatrics 90: 827 (1977) Theophylline kinetics: intrapatient variability. Walson, P.O. et al. Journal of Pediatrics 91 : 321 (1977) Theophylline therapy - author replies. Kern, J. W. Drug Intelligence and Clinical Pharmacy II: 494 (1977) Variation in theophylline clearance rate. Weinberger, M. Journal of Allergy and Clinical Immunology 60: 271 (1977) Theophylline kinetics in acute pulmonary odema. Piafsky, K.M. et al. Clinical Pharmacology and Therapeutics 21: 310 (1977) Theophylline clearance (C I) in acutely ill patients with asthma and chronic obstructive pulmonary disease (COPD) with and without congestive heart failure (CHF) and pneumonia. Powell, J.R. et al. American Review of Respiratory Disease 115: 152 (Suppl. 4, 1977) Apparent theophylline half-life fluctuations during treatment of acute left ventricular failure. Jenne, J. W. et al. American Journal of Hospital Pharmacy 34: 408 (1977) Theophylline concentrations in asthmatic patients. Kordash, T.R. et al. Journal of the American Medical Association 238: 139 (1977) Unpredictability of theophylline saliva measurements in chronic obstructive pulmonary disease. Hendeles, L. et al. Journal of Allergy and Clinical Immunology 60: 335 (1977) Theophylline: What dosage? Hempton, D. Medical Journal of Australia 2: 652 (1977) Plasma theophylline in exacerbations of coad. Dally, M.B. et al. Australian and New Zealand Journal of Medicine 7: 665 (1977) Relationship of serum theophylline concentration to inhibition of exerciseinduced bronchospasm and comparison with cromolyn. Pollock, J. et al. Pediatrics 60: 840 (1977) Lung functions and blood levels after parenteral administration of theophylline-ethylenediamine. Wiebmann, K.-J. et al. Deutsche Medizinische Wochenschrift 102: 1916 (1977) Questions on serum levels of theophylline. Tinkelman, D.G. et al. Pediatrics 61: 147(1978) Clinical application of serum theophylline measurement by high pressure liquid chromatography. McKenzie, S.A. et al. Archives of Disease in Childhood 53: 322 (1978) The value of estimating blood theophylline levels. Ruff. F. et al. Nouvelle Presse Medicale 7: 1750 (1978) Disposition of theophylline after a single intravenous infusion of aminophylline. Hendeles, L. et al. American Review of Respiratory Disease 118: 97 (l978) Pharmacokinetics of theophylline in ten elderly patients. Nielsen-Kudsk, F. et al. Acta Pharmacologica et Toxicologica 42: 226 (1978) Theophylline disposition in obesity. Gal. P. et al. Clinical Pharmacology and Therapeutics 23: 438 (1978) Pharmacokinetics of a microcrystalline theophylline preparation in patients with chronic obstructive airways disease. Elwood, R.K. et al. European Journal of Clinical Pharmacology 13: 29 (1978) Theophylline disposition in acutely ill hospitalized patients. The effect of smoking. heart failure, severe airway obstruction, and pneumonia. Powell. J .R. et al. American Review of Respiratory Disease I 18: 229 (1978)

0156-2703/79/0407-0019 $00.50/0

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Pharmacokinetics of theophylline in acute asthma. Simons, F. et al. Journal of Medicine 9: 81 (1978) Changes in theophylline clearance during acute illness. Vozeh, S. et al. Journal of the American MediCal Association 240: 1882 (1978) Oral theophylline dosage for the management of chronic asthma. Wyatt, R. et al. Journal of Pediatrics 92: 125 (j 978) The pharmacokinetics of theophylline in pregnancy. Sutton. P.L. et al. Journal of Allergy and Clinical Immunology 61: 174 (1978) Clinical pharmacokinetics of theophylline. Ogilvie, R.I. Clinical Pharmacokinetics J: 267(1978) Monitoring serum theophylline levels. Hendeles, L. et al. Clinical Pharmacokinetics 3: 294 (1978) The prevention of apnoea of prematurity with theophylline: A clinical, pharmacokinetic, and neurophysiological study. Demarquez, J.-L. et al. Archives Francaises de Pediatrie 35: 793 (( 978) Dose of theophylline for asthma. Weinberger, M. et al. Journal of Pediatrics 93: 536(1978) Do plasma theophylline levels condemn enteral forms? Dugue, P. et aI. Nouvelle Presse Medicale 7: 2656 (t 978) Pharmacokinetics of delayed (DR) versus sustained (SR) theophylline formulations following single (SO) and repetitive dosing (RD). Leung, P. et aI. Annals of Allergy 41 : 285 (1978) Theophylline. Mucklow, J.e. Adverse Drug Reaction Bulletin No.73: 262 ( 1978) Reliability of theophylline clearance in determining chronic oral dosage regimens. Siotfeldt, M.L. et al. American Journal of Hospital Pharmacy 36: 66 (1979) Impaired theophylline clearance in patients with corpulmonale. Vicuna, N. et aI. British Journal of Clinical Pharmacology 7: 33 (1979)

In the neonate Exchange transfusion for elimination of theophylline in the premature. Assael, B.M. et al.Journal of Pediatrics 91: 331 (1977) Theophylline pharmacokinetics in low birth weight neonate. Cottancin, G. et aI. Pediatrie 32: 677 (1977) Kinetics and efficacy of theophylline in the treatment of apnea in the premature newborn. Latini, R. et aI. European Journal of Clinical Pharmacology 13: 203 (1978) Correlation of plasma, saliva and spinal fluid levels of caffeine and theophylline in premature infants. Somani, S.M. et al. Pharmacologist 20: 256 (1978) Biotransformation of theophylline to caffeine in premature newborn. Bory, e. et al. Lancet 2: 1205 (1978) RelationShip between plasma and whole blood theophylline concentration in neonates. Koup, J.R. et al. Journal of Pediatrics 94: 320 (1979)

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and in infants and children

Theophylline disposition (TO) in infants aged 3 to 23 months. Simons, F.E.R. euL Annals of Allergy 3.8: 439 (1977) Dose-dependent kinetics of theophylline disposition in asthmatic children. Weinberger, M. et al.Journal of Pediairics 91: 820 (! 977) Relationship of theophylline clearance to oral dosage in children with chronic asthma. Ginchansky, E. et aI. Journal of Pediatrics 91: 655 (1977) Variation in theophylline clearance rate with time in chronic childhood asthma. Leung, P. et al. Journal of Allergy and Clinical Immunology 59: 440 (1977) Theophylline half-life in infants and young children. Kadlec, GJ. et al. Annals of Allergy 40: 303 (1978) Effect of practical timing of dosage on theophylline blood levels in asthmatic children treated with choline theophyllinate. McKenzie, S.A. et aI. Archives of Disease in Childhood 53: 167(1978) INPHARMA 7 Apr 1979

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Pharmacokinetics of oral theophylline in asthmatic children: evaluation of a new preparation. ·Theolair·. Haddad. Z.H. et al. Annals of Allergy 40: 167 (1978) A sustained release theophylline preparation: efficacy in childhood asthma with low serum theophylline levels. Rachelefsky, G.S. et al. Annals of Allergy 40: 252 (1978) Serum theophylline concentrations in asthmatic children. Sheen, A. et al. Annals of Allergy 41 : 327 (I978) Serum theophylline levels in asthmatic children after oral administration of two slow-release theophylline preparations. McKenzie , S. et al. Archives of Disease in Childhood 53: 943 (1978) Sustained-release theophylline therapy for chronic childhood asthma. Bell, T. eta!. Pediatrics 62: 352(1978) Pharmacokinetics of theophylline in infancy. Simons. F. et al. Journal of Clinical Pharmacology 18: 472 (1978) Acute theophylline intoxication. BiphaSic first order elimination kinetics in a child. Kadlec, GJ . et al. Annals of Allergy 41: 337 (1978) Effect of ampicillin on theophylline half-life in infants and young children. Kadlec, GJ. et al. Southern Medical Journal 71: 1584 (1978)

Effect of dialysis Hemodialysis clearance of theophylline. Levy. G. et al. Journal of the American Medical Association 237 : 1466 (1977) Dialysability of theophylline. Vaziri.N .D . etal. Jouf11alofDialysis 2: 243 ((978) Theophylline and dialysis. Zinno D. et al. Annals of Internal Medicine 89: 723 (1978)

-liver disease Theophylline disposition in patients with hepatic cirrhosis. Piafsky. K.M. et al. New England Journal of Medicine 296: 1495 (1977) Theophylline in liver disease. Lawyer, C.H. et aI. New England Journal of Medicine 297 : 1122( 1977) Pharmacokinetics of theophylline in hepatic disease. Mangione, A. et al. Chest 73: 616(1978)